Italian ryegrass (Lolium perenne) is one of the most troublesome weeds of rice in Mississippi. Its resistance to multiple modes of action has made it more difficult to control in recent years. The most effective and economical management strategy to control Italian ryegrass is fall-applied residual herbicides; however, the most effective products are not labeled for use in the fall prior to rice seeding. Therefore, research was conducted in Stoneville, MS, to evaluate the effect of fall-applied residual herbicides on rice growth and development. Acetochlor should not be applied in fall targeting Italian ryegrass in fields where rice is scheduled for seeding the following spring. Clomazone remains the only viable treatment as a fall-applied residual herbicide in rice areas.