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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 11 to 12 of 12 (0.063 seconds)Spelling suggestions: "subject:"rate diseases.""
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The effect of varying times of ischemia on the levels of glutathione in the cytosol and mitochondria of the rat kidneyTaylor, Matthew A. January 2002 (has links)
Ischemia caused by the disruption of blood flow results in kidney damage and dysfunction. This study investigated the effects of 30, 60 or 120 minutes of renal ischemia on the levels of glutathione (GSH), the major antioxidant inside cells. Kidneys from anesthetized female Lewis rats (9 months old) were clamped to induce ischemia and then homogenized and separated into cytosolic and mitochondria fractions by differential centrifugation. The levels of GSH and oxidized glutathione (GSSG) in the fractions were measured spectrophotometrically or by capillary electrophoresis. A significant reduction in GSH levels in the cytosol and mitochondria was seen only after the kidney underwent 60 minutes of ischemia. The significant decrease in GSH was accompanied by an increase in the GSSG/GSH ratio and an alteration in the glutathione redox ratio (i.e., GSH/total glutathione). This study demonstrates that an ischemic time of 60 minutes or longer is necessary to cause depletion of GSH levels in the rat kidney. / Department of Physiology and Health Science
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Analyse génétique du cancer du mammaire chez le rat: étude de lignées congéniquesPiessevaux, Géraldine 03 July 2008 (has links)
\ / Doctorat en Sciences / info:eu-repo/semantics/nonPublished
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