No description available.

Thesis (M.S.)--Oregon State College, 1939. / Typescript. Includes bibliographical references (leaves 52-62). Also available via the World Wide Web.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1971. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin, 1966. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1970. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Seven alkyl substituted methyl cyclopropanecarboxylates having an alkyl group on C-2 cis to the ester group have been found to rearrange thermally to their corresponding if, [formula omitted] esters at temperatures ranging from 240° to 300° . The corresponding trans isomers are unaffected under identical reaction conditions. It is proposed that the rearrangement takes place by an intramolecular 1,5-hydrogen transfer via a six-membered cyclic transition state. The kinetics for these reactions have been studied and show first-order plots which are linear to 70% reaction. The heat of activation [formula omitted] was found to be between 25 to 38 kcal/ mole and the entropy of activation [formula omitted] was found to be between - 8 and -37 eu from measurements made over a 20° range. This and other information fully support a cyclic hydrogen transfer mechanism. Four methyl cis-2-pentenoates have been found to undergo both geometric and positional thermal isomerizations to yield equilibrium mixtures of 2- and 3-pentenoates at temperatures ranging from 240° to 300°. The 3-pentenoates produced from the corresponding trans-2-pentenoates were found to be formed via the cis - 2-pentenoate3. Studies using β-isopropylacrylate and methacrylate showed that the rate of positional isomerization was much faster than that of geometric isomerization. For these systems it was therefore possible to study the kinetics of the positional isomerism in the absence of competing geometric isomerization, The kinetic data provided first-order plots. The heat of activation [formula omitted] was found to be between 18 and 38 kcal/mole and the entropy of activation [formula omitted] was found to be between -8 to -50 eu. An intramolecular 1,5-hydrogen transfer mechanism involving a six-membered cyclic transition state similar to that for the cyclopropane series is indicated and is suggested to be the general mechanism for conversion of [formula omitted] esters to [formula omitted] esters. The series of 2-alkylcyclopropanes have been prepared by the decomposition of the corresponding pyrazoline3. Some of these pyrazolines have been newly synthesized for this work and include [formula omitted] esters required for this research. Several, however, have also been synthesized by the modified Wittig reaction. / Science, Faculty of / Chemistry, Department of / Graduate

No description available.

To better understand the evolutionary dynamics of chromosomal inversions, a physical map for an Asian malaria vector, Anopheles stephensi, was created and compared with the maps of the major African malaria vectors A. gambiae and A. funestus No interchromosomal transposition was observed between A. gambiae and A. stephensi. Several cases of euchromatin and heterochromatin transitions weridentified between A. gambiae and A. stephensi. The study of paracentric inversions between lineages in Anopheles mosquitoes demonstrated that X chromosome has the fastest rate of inversion fixations and highest density of repetitive elements. Among the autosomes, 2R evolved faster than other autosomes. The slowly evolved autosomes have more M/SARs than rapidly evolving arms. Breakpoint regions are enriched with repetitive elements. The study revealed that fixed inversions are distributed nonrandomly and breakpoint clustering is common in lineages of A. gambiae and A. stephensi. The parallel association between the density of inversion fixations and polymorphisms suggests that polymorphic inversions can be fixed during evolution. To understand the direction of evolution in A. gambiae complex, the ancestral status of fixed inversions for this complex was identified. The presence of the 2La inversion in outgroups, A. stephensi and A. nili, confirmed the ancestral status of the 2La inversion. The presences of breakpoint structure of the 2Ro inversion in outgroup species, A. stephensi, indicated that the 2Ro is ancestral arrangement. The presence of SINE elements at the breakpoints of the 2R+p in A. gambiae PEST strain suggested that the 2R+p is a derived arrangement. Therefore, the carrier of 2Rop inversions, A. merus, was considered closest to the ancestral species. We have developed a new protocol for laser microdissection and whole genome amplification of polytene chromosomal fragments to obtain DNA for sequencing and assembly. The chromosomal regions spanning both breakpoints of the 2La in A. arabiensis and A. merus were laser microdissected from the polytene chromosomes. Subsequently, DNA samples were amplified using Illustra GenomePhi V2 DNA and Whole-pool amplification methods for obtaining amplicons. Successful amplification of our target DNA was confirmed by PCR with specific primers followed by Sanger sequencing. / Ph. D.

No description available.

No description available.