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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
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Cannabinoid modulation of chemotaxis of macrophages and macrophage-like cells /Raborn, Erinn Shenee. January 2007 (has links)
Thesis (Ph. D.)--Virginia Commonwealth University, 2007. / Prepared for: Dept. of Microbiology and Immunology. Bibliography: leaves 92-108. Also available online via the Internet.
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Cannabinoid effects on NF[kappa]B function in microglial-like cells : dual mode of action /Griffin-Thomas, LaToya Andrea, January 2009 (has links)
Thesis (Ph. D.)--Virginia Commonwealth University, 2009. / Prepared for: Dept. of Microbiology and Immunology . Bibliography: leaves 118-133 . Also available online via the Internet.
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Functional redistribution of hippocampal cannabinoid CB₁ receptors in the rat pilocarpine model of acquired epilepsy /Falenski, Katherine Winslow, January 2006 (has links)
Thesis (Ph. D.)--Virginia Commonwealth University, 2006. / Prepared for: Dept. of Neurology. Bibliography: leaves 180-205. Also available online.
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Molecular mechanisms of CB1 cannabinoid receptor signaling and internalization /Daigle, Tanya L. January 2007 (has links)
Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 100-108).
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Cannabinoids induce immunoglobulin class switching to IgE in B lymphocytes /Agudelo, Marisela. January 2009 (has links)
Dissertation (Ph.D.)--University of South Florida, 2009. / Includes vita. Includes bibliographical references. Also available online.
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Cannabinoids induce immunoglobulin class switching to IgE in B lymphocytesAgudelo, Marisela. January 2009 (has links)
Dissertation (Ph.D.)--University of South Florida, 2009. / Title from PDF of title page. Document formatted into pages; contains 92 pages. Includes vita. Includes bibliographical references.
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Molekulární mechanismus regulace signalizace kanabinoidního receptoru 1 proteinem SGIP1 / Molecular mechanism of Cannabinoid receptor 1 regulation by SGIP1Dvořáková, Michaela January 2021 (has links)
Molecular mechanism of Cannabinoid receptor 1 regulation by SGIP1 Abstract Src homology 3-domain growth factor receptor-bound 2-like endophilin interacting protein 1 (SGIP1) has been identified as an interacting partner of cannabinoid receptor 1 (CB1R). Their protein-protein interaction was confirmed by co-immunoprecipitation. SGIP1 hinders the internalization of activated CB1R and modulates its signaling in HEK293 cells. Employing whole-cell patch-clamp electrophysiology, we have shown that SGIP1 affects CB1R signaling in autaptic hippocampal neurons. Using a battery of behavioral tests in SGIP1 constitutive knock-out (SGIP1-/- ) and WT mice, we investigated the consequences of SGIP1 deletion on behavior regulated by the endocannabinoid system. In SGIP1-/- mice, exploratory levels, working memory and sensorimotor gating were unaltered. SGIP1-/- mice showed decreased anxiety-like and depressive-like behaviors. Fear extinction to tone was enhanced in SGIP1-/- females. Several cannabinoid tetrad behaviors were altered in the absence of SGIP1. SGIP1-/- males exhibited abnormal THC withdrawal behaviors. SGIP1 deletion also reduced acute nociception, and SGIP1-/- mice were more sensitive to antinociceptive effects of CB1R agonists and morphine. CB1R-SGIP1 interaction results in profound modification of CB1R...
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