Global ETD Search

21	The development of sensitization to amphetamine : a possible involvement of netrin-1 receptors Yetnikoff, Leora. January 2007 (has links) Repeated exposure to amphetamine (AMPH) induces sensitization to its behavioral-activating effects. The development of sensitization depends on (1) the direct actions of AMPH in the ventral tegmental area (VTA), the cell body region of the mesocorticolimbic DA system, and (2) AMPH-induced glutamatergic neurotransmission in this region. Moreover, sensitization is accompanied by morphological changes in mesocorticolimbic DA circuitry. During development, the DA system is organized, at least in part, by the netrin-1 family of guidance cues. Both netrin-1 and its DCC and UNC-5 receptors continue to be expressed in the mesocorticolimbic DA system of the adult brain. Importantly, netrin-1 receptor deficient mice do not develop sensitization to AMPH, implicating an involvement of netrin-1 signaling in AMPH-induced plasticity of the DA system. To explore this possibility, adult rats were pretreated with repeated AMPH or saline, and DCC and UNC-5 receptor expression was examined in DA cell body and terminal regions using western blot. Striking AMPH-induced increases in the expression of DCC and UNC-5 were observed in the VTA only. Remarkably, these changes depended on NMDA-mediated glutamatergic neurotransmission. This is the first demonstration that repeated AMPH pretreatment regulates netrin-1 receptor expression in the adult brain and suggests that netrin-1 receptor regulation may be involved in the development of AMPH-induced sensitization. Receptors, Nerve Growth Factor. Receptors, Cell Surface.
22	Repressing the hedgehog signalling pathway : functional analysis of the tumour suppressors patched1 and suppressor of fused / Svärd, Jessica, January 2007 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.
23	Studies of high mobility group box chromosomal protein 1 as a pro-inflammatory cytokine / Mullins, Gail E., January 2005 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 4 uppsatser.
24	Notch receptor processing and CNS disease / Karlström, Helena, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2002. / Härtill 4 uppsatser.
25	Role of toll-like receptors in host responses to mucosal bacterial infections / Bäckhed, Fredrik, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 4 uppsatser.
26	Signalling and activation of TLR4 by Gram-negative bacteria in epithelial cells / Meijer, Lisa, January 2003 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.
27	The identification of molecular guidance cues necessary for development of the central auditory system Howell, David M. January 2009 (has links) Thesis (Ph. D.)--West Virginia University, 2009. / Title from document title page. Document formatted into pages; contains x, 192 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
28	Mechanism of physiological function of sphingosine-1-phosphate : extracellular action and demonstration of alleged receptor / Yamamura, Soichiro. January 1998 (has links) Thesis (Ph. D.)--University of Washington, 1998. / Vita. Includes bibliographical references (leaves [132]-134).
29	The signal transduction pathways initiated by CD8 during apoptosis of thymocytes / Clarke, Raedun Laurie. January 2007 (has links) Thesis (Ph.D. in Immunology) -- University of Colorado Denver, 2007. / Typescript. Includes bibliographical references (leaves 236-251). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
30	The role of retinal-specific transcription factors in neurogenesis / Chow, Lely, January 1999 (has links) Thesis (Ph. D.)--University of Washington, 1999. / Vita. Includes bibliographical references (leaves 112-134).

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