• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 4000
  • 1185
  • 864
  • 736
  • 521
  • 302
  • 202
  • 134
  • 74
  • 71
  • 63
  • 58
  • 58
  • 58
  • 58
  • Tagged with
  • 9978
  • 1371
  • 940
  • 865
  • 765
  • 760
  • 747
  • 643
  • 603
  • 594
  • 582
  • 569
  • 551
  • 502
  • 451
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
401

Alternative Regulierungsansätze im Kontext der Better Regulation Agenda : eine Analyse von Konzepten, Potenzialen und Erfolgsfaktoren von Regulierung im Schatten staatlicher Hierarchie / Alternative forms of regulation and the Better Regulation Agenda : an analysis of concepts, potentials and success factors of regulation in the shadow of hierarchy

Denker, Philipp January 2008 (has links)
Der vorliegende Beitrag untersucht das Potential und die Bedingungen alternativer Regulierungsformen vor dem Hintergrund von Better Regulation in Deutschland. Nahezu alle EU- und OECD-Staaten betreiben heute umfassende politische Reformprogramme zur Modernisierung der Regulierungsarchitekturen, die unter dem Label Better Regulation subsumiert werden. Die Zielsetzung dieser Programme besteht zum einen in der wirtschaftsfreundlichen Reduktion von Regulierungskosten und zum anderen in der Effektivitätssteigerung von Regulierung durch Vermeidung unintendierter Nebeneffekte. Better Regulation ist ein Toolkit verschiedener metaregulativer Policy-Instrumente, deren programmatische Zusammensetzung vom nationalen politischen Kontext abhängt. Im Rahmen der parallel verlaufenden Reformagenden werden überdies alternative Regulierungsformen von verschiedenen Advokaten besserer Regulierung thematisiert, und als Alternative zur rein staatlichen, hierarchischen Command-and-Control-Regulierung (CaC-Regulierung) promotet, jedoch weder näher auf deren Bedingungen noch deren Konsequenzen einzugehen. Den optimistischen Vorstellungen eines evidenzbasierten Regulatory Managements folgend, erfolgt die Prüfung und Analyse alternativer Regelungsformen im Zuge der Gesetzesfolgenabschätzung (GFA; Regulatory Impact Assessment RIA). Bisher fristen alternative Regulierungsformen allerdings ein Dasein im Schatten von Standardkosten-Modell, RIA und Co. und werden von den Policy-Makern nicht systematisch in Betracht gezogen oder eingesetzt. CaC-Regulierung ist und bleibt das dominante Steuerungsinstrument des Staates. Es existieren jedoch zahlreiche diskursive Anknüpfungspunkte einschließlich zahlreicher Kritiken an der hierarchisch-regulativen Steuerung, welche die Auseinandersetzung mit alternativen Regulierungsformen begründen. Ziel dieses Papieres ist es daher, die in der Kritik stehende CaC-Regulierung Modellen alternativer Regulierungsformen entgegenzustellen, wobei alternative Regulierung mit den Konzepten Selbstregulierung, Koregulierung und regulierter Selbstregulierung eng definiert wird, und nur jene Konstellationen betrachtet werden, die kooperativ zwischen Regierung und Wirtschaft operieren. Ebenso wird der Versuch unternommen, die mannigfaltigen Konzepte und Erscheinungsformen alternativer Regulierung zu definieren und zu kategorisieren. Im Anschluss an den theoretischen Part erfolgt im nächsten Schritt die Identifikation der Einsatz- und Erfolgsbedingungen alternativer Regulierung. Dies geschieht anhand zweier empirischer Fallbeispiele aus den Politikfeldern Berufsbildungspolitik („der Ausbildungspakt der deutschen Wirtschaft“) sowie Umweltpolitik („die Mehrwegquotenverpflichtung“), wobei gezielt ein erfolgreiches und gescheitertes Beispiel alternativer Regulierung verglichen werden und Erfolgsfaktoren abgeleitet werden. Das Ergebnis ist, dass alternative Regulierung gewisse Potentiale und Anreize für staatliche wie privatwirtschaftliche Akteure bietet, aber der Einsatz dieser Steuerungsformen höchst voraussetzungsvoll ist und nur in wenigen Politikfeldern möglich und zu empfehlen ist. So besteht das Potential alternativer Regulierungsformen vor allem in der ganzheitlichen Senkung von Regulierungskosten (Befolgungs- und Vollzugskosten) und in der Erhöhung der Steuerbarkeit der Adressaten. Allerdings sind die korporativen Akteure auf beiden Seiten zum einen nicht immer hinreichend auf diese Form indirekter Steuerung vorbereitet. Zum anderen wird alternative Regulierung durch die Fragmentierung und Schwäche von Wirtschaftsverbänden sowie durch Interessengegensätze unter den Regelungsadressaten gehindert, die in Trittbrettfahrertum und dem letztlichen Scheitern selbstregulativer Verpflichtungen münden. Als entscheidende, aber anspruchsvolle Erfolgskomponente erweisen sich die politische Kommunikation und die Durchsetzbarkeit staatlicher Sanktionen sowie die Erfolgskontrolle, um die Regelungseinhaltung durch die Wirtschaft zu gewährleisten. Generell ist zu konstatieren, dass alternative Regulierungsformen dort zustande kommen, wo sich konzentrierter Widerstand auf Seiten der Adressaten gegen geplante, autoritative Steuerung abzeichnet, eine gewisse Pfadabhängigkeit bzw. eine Historie sektoraler Selbstregulierung vorliegt und eine Win-Win-Situation bei der Kooperation für Politik und Wirtschaft ersichtlich ist. In der Konsequenz zeigen die Ergebnisse, dass alternative Regulierung nicht nach einem synoptisch-rationalen Modell politischer Prozesse entsteht, sondern ein ursprünglich nicht intendiertes Produkt Garbage Can-artiger Verhandlungen mit einem hohen Konfliktniveau darstellt. Folglich ist das Resultat für die Vorstellung einer „Rational Regulatory Choice“ induzierenden Better Regulation-Agenda desillusionierend. / This paper analyses the potentials and the preconditions of alternative forms of regulation against the background of Better Regulation in Germany. Today, almost every OECD- and EU-country runs extensive regulatory reform programs to modernize its regulatory governance structures, which are summarized under the label Better Regulation. The goal of this type of agenda can be regarded, firstly, as the business-friendly reduction of overall regulatory costs and secondly as the increase of regulatory efficiency by removing unintended side-effects. Better Regulation is a toolkit consisting of several meta-regulatory instruments, whose programmatic composition and use varies with the national political context. Moreover, within these parallel proceeding reform agendas alternative forms of regulation are constantly promoted by advocates of Better Regulation and portrayed as alternative to purely governmental command-and-control approaches (CaC), though neither responding to their preconditions nor addressing their consequences. According to the optimistic notion of an evidence-based regulatory management, the examination and analysis of regulatory alternatives is supposed to be carried out within regulatory impact assessments (RIA). However, hitherto alternative forms of regulations exist unnoted in the shadow of the standard cost model, RIA and co. and they are not systematically considered and applied by policy-makers. CaC-regulation is and remains the dominant and favoured policy-instrument of the state. Yet, there are several discursive connections including broad criticism on hierarchical-regulative steering, which give reason to the deeper analysis of alternative forms of regulation. Therefore the aim of this paper is to contrast alternative regulation with the criticized CaC-technique, whereas alternative regulation is defined narrowly as the concepts of self-regulation, co-regulation and regulated self-regulation which operate as cooperative substitutes of CaC between government and business. Moreover, this paper attempts to define and to categorize the diverse concepts and natures of alternative regulation. Subsequent to the theoretical part the preconditions and critical success factors for alternative regulation are identified in the next section. For this purpose two empirical case studies from two different policies, under which one is successful and the other has failed, are examined and compared to deduce success factors. The case studies are from vocational training policy (“The Training Pact of the German Business”) and waste policy (“refill quota for beverage containers”). The result is that alternative forms of regulation offer several potential und incentives for state and business actors, but that the use of these policy instruments is highly demanding and in addition only possible and recommendable in few policies. Undoubtedly its potential lies in the holistic reduction of regulatory costs (compliance and enforcement costs) and in the enhancement of the governability of the regulated business. However, the corporate actors on both sides are not always adequately prepared for this indirect mode of steering. Furthermore, alternative regulation is hindered by the fragmentation and weakness of business associations and opposing interests among the regulated sectors and companies, which may lead to free-riding and could result in the final failure of alternative regulation. The political communication and assertiveness of public sanctions as well as the measurement of success, which ensure self-regulatory compliance, turned out to be decisive, but very demanding constituents of success. Generally speaking, alternative forms of regulation emerge in those cases and policy areas, where concentrated resistance against planned CaC-measures becomes apparent, where a certain path dependency or history of sectoral self-regulation exists, and where a win-win-situation becomes obvious for politicians and business. To sum up, this paper argues that alternative regulations don’t emerge by a synoptic-ration model of policy process, but that they present an unintended product of garbage can like policy processes, further characterized by a high level of conflict. Consequentially, this paper’s findings disillusion the (exaggeratedly) optimistic notion of a rational regulatory choice inducing Better Regulation agenda.
402

Translational Regulation in the Early Drosophila Embryo

Nelson, Meryl 19 January 2009 (has links)
Translational regulation is an important mechanism for regulating gene expression. Regulation of specific transcripts is often mediated by elements present in the 3′ untranslated region (UTR) of the mRNA. In the Drosophila embryo, translational repression of nanos mRNA is mediated by Smaug protein bound to specific sequences present in the 3′ UTR of the mRNA. Here I show that Smaug recruits Cup protein to the mRNA and that Cup in turn binds to the translation initiation factor eIF4E that is present at the 5′. The interaction between Cup and eIF4E prevents formation of a productive translation initiation complex on the mRNA. Therefore, Smaug-dependent translational repression functions at the initiation step via the indirect interaction of Smaug with eIF4E, which is mediated by Cup. In the second example of translational regulation presented here, I show that an element present in the 3′ untranslated region of the Hsp83 mRNA mediates translational enhancement in the Drosophila embryo. I have identified three proteins, Hrp48, DDP1 and PABP that interact with this element and have demonstrated that Hrp48 and DDP1 function in translational enhancement.
403

Regulation in Switched Bimodal Linear Systems

Wu, Zhizheng 28 September 2009 (has links)
In the past few decades, significant progress has been made in addressing control problems for a variety of engineering systems having smooth dynamics. In practice, one often encounters also non-smooth systems in various branches of science and engineering, such as for example mechanical systems subject to impact. Motivated by the read/write head flying height regulation problem in hard disk drives, where the close proximity of the read/write head to the disk surface results in intermittent contact between the two and a bimodal system behavior, this thesis studies the output regulation problem in switched bimodal linear systems against known and unknown exogenous input signals. The regulation problems in bimodal systems presented in this thesis are solved within sets of Q-parameterized controllers, in which the Q parameters are designed to yield internal stability and exact output regulation in the closed loop switched system. The proposed parameterized controllers are constructed mainly in two steps. The first step is based on constructing a switched observer-based state feedback central controller for the switched linear system. The second step involves augmenting the switched central controller with additional dynamics (i.e. Q parameter) to construct a parameterized set of switched controllers. Based on the proposed sets of Q-parameterized controllers, four main regulation problems are addressed and corresponding regulator synthesis algorithms are proposed. The first problem concerns regulation against known deterministic exogenous inputs, where no stability or structural constraints are imposed on the Q parameter. The second problem is similar to the first, except that the Q parameter is constrained to be a linear combination of basis functions. This structure of the Q parameter is considered in the rest of the thesis. The third problem involves regulation against exogenous inputs involving known deterministic components and unknown random components, and where the regulator is designed subject to an H2 performance constraint. The last problem involves the development of adaptive regulators against unknown sinusoidal exogenous inputs. The different regulator synthesis algorithms are developed based on solving sets of linear matrix inequalities or bilinear matrix inequalities. The last two proposed regulation methods are successfully evaluated on an experimental setup motivated by the flying height regulation problem in hard disk drives, and involving a mechanical system with switched dynamics.
404

The influence of state and trait energy on self-regulatory behaviour

Holmqvist, Maxine Elisabeth 12 January 2009
Self-regulation is a highly adaptive process that enables goal-directed behaviour; however, individuals often fail to self-regulate successfully. Failures of self-regulation in the domain of health may be particularly harmful especially for those with chronic diseases. The Energy Model articulated by Baumeister and colleagues proposes that all acts of self-regulation rely on a single, finite energy resource. Thus, one possible explanation for self-regulation failure is insufficient energy. In the current research, four studies examine the relationship between the construct of energy, which can manifest in state or trait form, and self-regulatory success. Past research has demonstrated that individuals who perform two sequential tasks requiring self-regulation perform worse on the second task (the self-regulatory fatigue effect). The Energy Model proposes that this performance decrement can be explained by energy depletion. If this is true, then state energy should mediate the self-regulatory fatigue effect. A series of three experimental studies (studies 1-3) were designed to test this hypothesis. In Study 1, participants were randomly assigned to a gaze regulation task or to a no-regulation control group (as in Schmeichel et. al, 2003) before they watched a brief video clip. Following this first task, all participants worked on a second self-regulatory task (solving anagrams). Persistence and performance on this second task were the dependent measures and energy was measured before and after the initial video task. Contrary to the predictions of the Energy Model, the self-regulatory fatigue effect was not replicated in this study and so the mediating potential of energy could not be tested. However, ratings of task difficulty and effort suggested that individuals in the gaze regulation condition did not find this task to be very challenging. Accordingly, a second study was designed that added an additional level of self-regulatory demand by asking participants to rehearse a 7-digit number during the video clip (memory regulation). When this was crossed with the gaze regulation manipulation, four conditions were created: no regulation, gaze regulation only, memory regulation only and memory + gaze regulation. Study 2 then followed the same approximate procedure as Study 1, with individuals randomly assigned to one of the four conditions. The results of this study were consistent with Study 1 in that the self-regulatory fatigue effect was not replicated. However, the manipulation check suggested that some of the participants in the gaze regulation conditions may not have adhered to experimental instructions and the conditions may have differed in the degree to which they were enjoyable and interesting to participants. Accordingly, a third study used an eye-tracker to assess self-regulation during the video task and evaluated aspects of task engagement. Study 3 followed the same procedures as Study 2. Eye-tracker data verified significant differences between the groups in terms of self-regulation during the initial video task; however, there were no other significant between group differences. Taken together, these 3 studies indicate that the self-regulatory fatigue effect may be less robust than previous research would suggest. An unexpected finding was the high degree of variability in the energy measures, which implied that individual differences in energy may be important to consider. Accordingly, Study 4 prospectively examined the role of dispositional energy in the self-regulation of diet and exercise behaviour by testing whether energy moderated intention-behaviour concordance in a sample of individuals newly diagnosed with Type 2 diabetes. This study demonstrated that energy predicted future exercise behaviour in this sample and provided some preliminary support for the hypothesis that individuals with higher levels of dispositional energy may show more intention-behaviour concordance than those with lower levels of dispositional energy. Overall, these 4 studies provide some tentative support for the role of dispositional energy in the implementation of health behaviour, but do not support the Energy Models predictions regarding self-regulatory fatigue.
405

Corruption, the unofficial economy and the provision of public goods in transition countries

Çule, Monika 13 January 2006
For more than a decade, the countries of Central and Eastern Europe and the former Soviet Union have been attempting to transform their centrally planned economies into market economies. In some of these countries a considerably large unofficial economy has become a serious obstacle to economic growth and public finances. Studies by Johnson et al. (1997), Johnson et al. (1998), and Johnson et al. (2000) show that transition countries with large unofficial economies tend to have excessive regulations, high levels of taxation and high incidence of corruption. As well, bureaucratic corruption in tax and customs administration appears to be an important element in defining the underground economy in some transition countries. </p> <p>Given the potential impact of the unofficial economy on public finances and the provision of public goods, the purpose of this dissertation is to examine how corruption affects the unofficial economy in transition countries, with a particular focus on the unofficial economy that results from tax non-compliance. More specifically the study examines tax cheating as it relates to corruption in tax administration, to the business culture in the economy and to the tax-regulation policy-making process. The thesis looks at the feedback effects of decisions of different agents in the economy, and the implications of these decisions for the provision of public goods. </p> <p>The research is conducted along two lines. First, the thesis examines the nature and the extent of corruption in Albania, focusing particularly on the informal sector and corruption in customs and tax administrations. The thesis also examines the implications of the informal economy on the tax revenues available for the provision of public goods. Then the thesis examines the pattern of government spending in public education and transport infrastructure in Albania to reveal the priorities that these sectors are being given during the transition period. Second, the thesis develops a number of theoretical models to examine some of the issues raised in the analysis of Albania. The theoretical models provide a framework to examine the incentives for different agents in the economy to engage in tax cheating and corruption. More specifically, this section of the thesis examines: the feedback effects between the decision of tax inspectors to engage in corruption and firms' cheating activities; the firms' tax compliance as tax cheating and corruption are more accepted practices when they become increasingly widespread; how government affects the degree of cheating and corruption through auditing; and how corruption affects policy-makers' decisions to allocate the revenue obtained from tax collection between public education and infrastructure. </p> <p>Results from the theoretical models show that widespread bureaucratic corruption among tax inspectors can perpetuate an unofficial economy that in turn sustains these and other corrupt practices. In such situations, intense auditing and penalties serve as cheating deterrents only if cheating and engaging in corruption is very costly for both firms and tax inspectors. When cheating becomes cheaper as the size of the unofficial economy grows, a multiplier effect in the economy gives rise to Pareto-ranked multiple equilibria. In an economy with a widespread tolerance for corrupt tax enforcers, tax non-compliance and a low enforcement of penalties, the Pareto inferior (large unofficial economy and an under-provision of public goods) stable equilibrium can prevail. Changes that will move an economy from an inferior equilibrium to a superior equilibrium have a strong political dimension and are complex.</p> <p>Modeling the ways in which policy-makers affect the unofficial economy indicates that, due to the high cost of auditing, the government must allow for some cheating and corruption in order to maximize the revenues available for the provision of public goods. Only if a government views illicit activities as a "public bad", and is willing to eliminate these activities at any cost, will it choose to perform very intense auditing. The government's decision to allocate revenues between education and infrastructure depends on the returns generated by these public goods in the economy and on the private benefits from corruption. A government will allocate funds to education only if education generates relatively higher returns, and if the government favours at the margin the provision of public goods relative to private benefits from corruption. If at the margin the government favours the private benefits from corruption and cheating, then all revenues are allocated to infrastructure even though education generates higher relative returns in the economy. When infrastructure generates higher social returns in the economy, the government commits revenues to infrastructure either to provide the most beneficial public good, or to facilitate opportunities for corruption benefits. Overall the thesis shows that illicit activities (cheating, and political and bureaucratic corruption) can sustain each other regardless which actors in the economy (firms, enforcers, and politicians) undertake them.
406

Preliminary Investigation of the Relationship Between Emotion Processing Variables and Difficulties in Affect Regulation With the Use of Affect Regulation Strategies

Recoskie, Kimberly 14 December 2009 (has links)
A preliminary measure of affect regulation strategies was developed from Parkinson and Totterdell’s (1999) provisional classification of deliberate strategies for improving negative affect. Four broad categories of strategies including Cognitive Engagement, Cognitive Diversion, Behavioural Engagement, and Behavioural Diversion were represented by the measure. Using this measure, relationships between self-reported use of affect regulation strategies and difficulties in emotion regulation and emotion processing variables were investigated. Participants included 186 adults. Participants completed a 20 minute online survey consisting of the measure of affect regulation strategies, the Difficulties in Emotion Regulation Scale (DERS), the Subjective Experience of Emotions Scale (SEE), and a demographic information questionnaire. Weak correlations were found for the majority of the difficulties in emotion regulation and emotion processing subscales and individuals’ self-reported use of affect regulation categories. Results also provide evidence of convergent and discriminant validity for the DERS and SEE.
407

Mechanisms of Vts1-Mediated Repression in S. cerevisiae

Orlowicz, Agata 25 August 2011 (has links)
Vts1p is the Saccharomyces cerevisiae member of the Smaug family of post-transcriptional regulators, which is a group of sequence-specific RNA-binding proteins that regulate target mRNA expression. Vts1p is known to mediate deadenylation-dependent degradation of target transcripts through the recruitment of the Ccr4p/Pop2p/Not deadenylase complex. By conducting a functional analysis of Vts1p deletion mutants, I demonstrate that two regions within Vts1p are independently capable of downregulating the expression of an mRNA reporter. I provide both genetic and biochemical evidence that suggests residues 170-523 regulate reporter expression at the level of mRNA stability and function through a mechanism that requires the Ccr4p/Pop2p/Not deadenylase, whereas residues 1-237 repress reporter expression at the level of translation and function through a novel mechanism. In addition, I map a direct interaction between the eIF4E-binding protein, Eap1p, and the Vts1p SAM domain, which suggests a model in which residues 170-523 recruit Eap1p to mediate efficient target transcript degradation.
408

Mechanisms of Vts1-Mediated Repression in S. cerevisiae

Orlowicz, Agata 25 August 2011 (has links)
Vts1p is the Saccharomyces cerevisiae member of the Smaug family of post-transcriptional regulators, which is a group of sequence-specific RNA-binding proteins that regulate target mRNA expression. Vts1p is known to mediate deadenylation-dependent degradation of target transcripts through the recruitment of the Ccr4p/Pop2p/Not deadenylase complex. By conducting a functional analysis of Vts1p deletion mutants, I demonstrate that two regions within Vts1p are independently capable of downregulating the expression of an mRNA reporter. I provide both genetic and biochemical evidence that suggests residues 170-523 regulate reporter expression at the level of mRNA stability and function through a mechanism that requires the Ccr4p/Pop2p/Not deadenylase, whereas residues 1-237 repress reporter expression at the level of translation and function through a novel mechanism. In addition, I map a direct interaction between the eIF4E-binding protein, Eap1p, and the Vts1p SAM domain, which suggests a model in which residues 170-523 recruit Eap1p to mediate efficient target transcript degradation.
409

Preliminary Investigation of the Relationship Between Emotion Processing Variables and Difficulties in Affect Regulation With the Use of Affect Regulation Strategies

Recoskie, Kimberly 14 December 2009 (has links)
A preliminary measure of affect regulation strategies was developed from Parkinson and Totterdell’s (1999) provisional classification of deliberate strategies for improving negative affect. Four broad categories of strategies including Cognitive Engagement, Cognitive Diversion, Behavioural Engagement, and Behavioural Diversion were represented by the measure. Using this measure, relationships between self-reported use of affect regulation strategies and difficulties in emotion regulation and emotion processing variables were investigated. Participants included 186 adults. Participants completed a 20 minute online survey consisting of the measure of affect regulation strategies, the Difficulties in Emotion Regulation Scale (DERS), the Subjective Experience of Emotions Scale (SEE), and a demographic information questionnaire. Weak correlations were found for the majority of the difficulties in emotion regulation and emotion processing subscales and individuals’ self-reported use of affect regulation categories. Results also provide evidence of convergent and discriminant validity for the DERS and SEE.
410

Translational Regulation in the Early Drosophila Embryo

Nelson, Meryl 19 January 2009 (has links)
Translational regulation is an important mechanism for regulating gene expression. Regulation of specific transcripts is often mediated by elements present in the 3′ untranslated region (UTR) of the mRNA. In the Drosophila embryo, translational repression of nanos mRNA is mediated by Smaug protein bound to specific sequences present in the 3′ UTR of the mRNA. Here I show that Smaug recruits Cup protein to the mRNA and that Cup in turn binds to the translation initiation factor eIF4E that is present at the 5′. The interaction between Cup and eIF4E prevents formation of a productive translation initiation complex on the mRNA. Therefore, Smaug-dependent translational repression functions at the initiation step via the indirect interaction of Smaug with eIF4E, which is mediated by Cup. In the second example of translational regulation presented here, I show that an element present in the 3′ untranslated region of the Hsp83 mRNA mediates translational enhancement in the Drosophila embryo. I have identified three proteins, Hrp48, DDP1 and PABP that interact with this element and have demonstrated that Hrp48 and DDP1 function in translational enhancement.

Page generated in 0.0846 seconds