Thesis--Wisconsin. / Vita. Includes bibliographical references (leaves 295-311).

Diss.--Universität Mannheim, 1995.

Cette thèse s’inscrit dans le cadre des recherches et vise à contribuer à la compérension du comportement mécanique d’une roche tendre (i.e. cataclastique grès). La roche étudiée se trouve dans une fondation d’un barrage, situé dans le sud-ouest de la chine. L'accent de des travaux réalisés dans cette thèse a concerné le comportement à long terme du matériau étudié.Pour caractériser le comportement mécanique et identifier les principaux paramètres qui le gouvernent, il était nécessaire d’aborder en première lieu avec une approche expérimentale. De nombreux essais ont été réalisé, tel que des essais de compression, des essais de fluage triaxiale et des mesures de perméabilité. On constate que la réponse mécanique du matériau dépends fortement la microstructure et les propriétés mécaniques ainsi que les contraintes appliquées. En se basant sur les résultats expérimentaux, un modèle unifiée est proposé pour décrire le comportement à court terme et à long terme du matériau étudié. Dans le modèle proposé, les principales caractéristiques observées dans les expériences sont prises en compte, en particulier des déformations irréversibles, la dépendance de la pression, la transition volumétrique entre le compaction et la dilatation ainsi que le fluage. La performance du modèle proposé est tout d’abords validé sur les essais homogènes. A la fin, une validation plus poussée de ce modèle a été réalisée dans le cadre d’applications à étudier la performance de la fondation. / The short term and long term mechanical behaviors of cataclastic sandstone are investigated in this dissertation. The studied material is cored from the fault zone in the dam foundation of a hydropower station in southwestern China. The emphasis is put on the long-term behavior of studied material. For this, conventional compression tests, multi-stage triaxial creep tests as well as the permeability measurements are performed. The mechanical behavior of studied rock is derived based on the experimental investigation. The mechanical responses of studied material are not only functions of the material properties, but are also related to applied stress. Based on the experimental investigation, a unified creep model is proposed to describe the instantaneous and time-dependent behavior of cataclastic sandstone. Main features observed in experiments are taken into account, in particular irreversible deformations, pressure dependency, volumetric transition between compaction and dilatancy and creep. The performance of the model is examined by comparing numerical simulations with test data in representative load paths. Finally, the model is applied to analyze the long term stability of a foundation of hydropower station.

Mergers and acquisitions (M&As) are one of the most important strategies for pharmaceutical and the biotechnology industry to gain access to valuable technological resources in recent years. The M&As activities and outcomes of famous pharmaceutical company ¡V Roche, and biotech leading company ¡V Genentech were investigated in this study. Thus, the innovation, product pipeline and financial performance were examined to elucidate the crucial strategies of M&As. Nowadays, the challenges of pharmaceutical company includes the growth rate of research and development (R&D) cost were higher than sales¡¦, new drugs development were slower than industry demand, licensing from other company and high profit patent drugs turned into generics. By innovative and vigorous development of biotechnology, biotech companies were devoted into niche products includes nucleic acid or protein drugs. However, large R&D expenditure and high risk product development result in capital shortage problems. The abundant working capital and well-experienced manufacture, marketing and sales characteristics of big pharma enable the M&As of pharma and biotech arise. This study case describe the M&A of an over a century pharmaceutical company ¡V Roche with a first IPO biotech company ¡V Genentech. To survey the process of licensing, merger, acquisition and public offerings, the motivation, strategies and outcomes were examined. In 2006, over the half of top ten sales of Roche were derived from Genentech; therefore, the global marketing and brand value of Roche contribute Genentech into the top one market value biotech company. The synergistic effect seems the M&A is a perfect integration. However, the majority equity owned by Roche and the oversea sales licensing to Roche were the further underlying problems for Genentech to expand to the top health care company in the world. The development of pharmaceutical company becoming more concentrated that the top ten pharmaceutics account for half of the global sales. Moreover, with the growing demand from the health care, aging and novel therapeutics and under the threatens of health insurance payment and patent drug expired, the tide of M&As for pharmaceutical and biotech companies will not decline. The weakness of Taiwan pharmaceutics is poor in innovation and generic drugs-oriented manufacture; furthermore, the biotech industry is still beyond maturity. Under the waves of M&As, the Taiwan pharmaceutical and biotech industry may prompt development by M&As. In this case study, the pharmaceutics and biotech background were first introduced and the case history, M&A process and strategies, product portfolio, R&D and financial issues were explored. Therefore, this study may fulfill and provide some suggestions and references for further pharmaceutical and biotech M&A activities in Taiwan.

No description available.

Th. univ.--Géochimie fondamentale et appliquée--Paris 7, 1993. / La couv. porte en plus : "substances minérales et énergétiques" Bibliogr. p. 203-220. Résumé en français et en anglais.

Th. doct.--Sci. de la terre--Grenoble 1, 1993. / Résumé en français et anglais.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1984. / Typescript. Vita. Includes bibliographical references (leaves 304-334).

Inaug.-Diss.--Greifswald. / Vita. Bibliography: p. [5]-7.

Th. 3e cycle--Géogr. hum.--Nantes, 1986.