Objective: To evaluate the impact of rubella vaccination strategies on rubella and CRS incidence and to offer public health suggestions for vaccination strategy in China. Methods: A systematic research of studies was conducted via the United States National Library of Medicine and the National Institutes of Health Medical Database (PubMed) and Google Scholar database. Terms- rubella AND (vaccin* AND coverage AND (reproduct* OR transmiss*) were used as key words in the research via PubMed. “Rubella vaccination strategies” and “rubella and congenital rubella syndrome” and “incidence” were used to search via Google Scholar. A systematic review of literature was conducted. The effectiveness of rubella vaccination strategies on the control and elimination of rubella and CRS incidence was used as primary inclusion criteria. Results: 5 articles were selected according to inclusion criteria. They were two cohort studies, two ecological studies, one mathematical modeling study. From the experience in Canada, around 99% decline of rubella and CRS incidence happened after vaccination strategy with selective approach for children. However, it led to a shift of infection to susceptible groups, and couldn’t interrupt rubella virus circulation. A combined vaccination with adults could control CRS incidence but was not effective for CRS elimination. A vaccination strategy with universal approach for children, males and females in Brazil could prevent child-bearing women from re-infection, thus helped to eliminate CRS cases. Conclusion: Vaccination strategy with universal approach was most effective for CRS control in a short time period with the evidence of a huge reduction of rubella and CRS incidence. As part of national immunization program in China, routine vaccination strategy for rubella should consider both epidemic and demographic factors to assess the effectiveness of children vaccination strategy. / published_or_final_version / Public Health / Master / Master of Public Health