Objective: To evaluate the impact of rubella vaccination strategies on rubella and CRS incidence and to offer public health suggestions for vaccination strategy in China. Methods: A systematic research of studies was conducted via the United States National Library of Medicine and the National Institutes of Health Medical Database (PubMed) and Google Scholar database. Terms- rubella AND (vaccin* AND coverage AND (reproduct* OR transmiss*) were used as key words in the research via PubMed. “Rubella vaccination strategies” and “rubella and congenital rubella syndrome” and “incidence” were used to search via Google Scholar. A systematic review of literature was conducted. The effectiveness of rubella vaccination strategies on the control and elimination of rubella and CRS incidence was used as primary inclusion criteria. Results: 5 articles were selected according to inclusion criteria. They were two cohort studies, two ecological studies, one mathematical modeling study. From the experience in Canada, around 99% decline of rubella and CRS incidence happened after vaccination strategy with selective approach for children. However, it led to a shift of infection to susceptible groups, and couldn’t interrupt rubella virus circulation. A combined vaccination with adults could control CRS incidence but was not effective for CRS elimination. A vaccination strategy with universal approach for children, males and females in Brazil could prevent child-bearing women from re-infection, thus helped to eliminate CRS cases. Conclusion: Vaccination strategy with universal approach was most effective for CRS control in a short time period with the evidence of a huge reduction of rubella and CRS incidence. As part of national immunization program in China, routine vaccination strategy for rubella should consider both epidemic and demographic factors to assess the effectiveness of children vaccination strategy. / published_or_final_version / Public Health / Master / Master of Public Health

The ground work for this research thesis was completed seven years ago when the Dow Pharmaceutical Company selected Muncie, Indiana to test their new rubella vaccine. In the Fall of 1970, 311 seronegative elementary school children were innoculated with HPV-77, DK12 rubella vaccine. Of the 302 children who seroconverted, 98 were available for follow-up six years post innoculation. The participant's sera drawn six years previously was recovered in order to determine a six week and six year post innoculation titer on paired specimens. All 98 children, when retested, has measurable antibody. The geometric mean titer six years post innoculation was 55; a 14% decrease from the geometric titer of 64 six weeks after innoculation. At the six year point in time, there was at least a 9.2% incidence of subclinical reinfection, detected by a fourfold rise in the HI-titer, within the study group.Ball State UniversityMuncie, IN 47306

Analysis of Spontaneous Adverse Events Reports of Measles, Mumps, and Rubella Vaccine Author: Jana Kulhavá Supervisor: PharmDr. Eva Zimčíková, Ph.D. Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy Keywords: vaccination, measles, mumps, rubella, adverse events reports Introduction: The MMR vaccine is a combined vaccine used to vaccinate children against measles, mumps and rubella. Spontaneous reporting of adverse reactions is an important source of information to identify potential risks of medicinal products. Objective: The aim of this diploma thesis is the analytical evaluation of spontaneous reports of suspected adverse reactions after vaccination with MMR vaccine registered in the database of the State Institute for Drug Control during the period 2004 to 2017. Methods: The data were analyzed in Microsoft Excel spreadsheet software using descriptive statistics methods. The reported adverse reactions were classified into appropriate organ system classes according to the MedDRA Glossary of Medical Terminology. The expectability and severity of adverse reactions were assessed. Results: A total of 805 cases of suspected adverse reactions were reported between 2004 and 2007, which included 2,812 adverse reactions. Most suspected adverse...

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第18173号 / 医博第3893号 / 新制||医||1003(附属図書館) / 31031 / 京都大学大学院医学研究科医学専攻 / (主査)教授 中山 健夫, 教授 木原 正博, 教授 一山 智 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DGAM