Doctor of Philosophy / Department of Statistics / Weixin Yao / This dissertation consists of three parts that are related to semiparametric mixture models. In Part I, we construct the minimum profile Hellinger distance (MPHD) estimator for a class of semiparametric mixture models where one component has known distribution with possibly unknown parameters while the other component density and the mixing proportion are unknown. Such semiparametric mixture models have been often used in biology and the sequential clustering algorithm. In Part II, we propose a new class of semiparametric mixture of regression models, where the mixing proportions and variances are constants, but the component regression functions are smooth functions of a covariate. A one-step backfitting estimate and two EM-type algorithms have been proposed to achieve the optimal convergence rate for both the global parameters and nonparametric regression functions. We derive the asymptotic property of the proposed estimates and show that both proposed EM-type algorithms preserve the asymptotic ascent property. In Part III, we apply the idea of single-index model to the mixture of regression models and propose three new classes of models: the mixture of single-index models (MSIM), the mixture of regression models with varying single-index proportions (MRSIP), and the mixture of regression models with varying single-index proportions and variances (MRSIPV). Backfitting estimates and the corresponding algorithms have been proposed for the new models to achieve the optimal convergence rate for both the parameters and the nonparametric functions. We show that the nonparametric functions can be estimated as if the parameters were known and the parameters can be estimated with the same rate of convergence, n[subscript](-1/2), that is achieved in a parametric model.

Master of Science / Department of Statistics / Weixin Yao / In this report, we introduce the minimum Hellinger distance (MHD) estimation method and review its history. We examine the use of Hellinger distance to obtain a new efficient and robust estimator for a class of semiparametric mixture models where one component has known distribution while the other component and the mixing proportion are unknown. Such semiparametric mixture models have been used in biology and the sequential clustering algorithm. Our new estimate is based on the MHD, which has been shown to have good efficiency and robustness properties. We use simulation studies to illustrate the finite sample performance of the proposed estimate and compare it to some other existing approaches. Our empirical studies demonstrate that the proposed minimum Hellinger distance estimator (MHDE) works at least as well as some existing estimators for most of the examples considered and outperforms the existing estimators when the data are under contamination. A real data set application is also provided to illustrate the effectiveness of our proposed methodology.