The zinc-finger transcription factor Senseless is co-expressed with basic helix-loop -helix (bHLH) proneural protein in Drosophila sensory organ precusors and is required for their normal development. Recently, we analysed Senseless protein sequence with bioimformatics and found many SUMOs consensus sites. In this study, we successfully performed in vitro sumoylation of Senseless proteins and observed the colocalisation between Senseless and SUMOs protein.