Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2001. / Vita. Includes bibliographical references.

Thesis (M App Sc) -- University of South Australia, 1992

Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1994. / Vita. Abstract. Includes bibliographical references (leaves 48-53). Also available via the Internet.

Thesis (Ph.D.)--University of Texas at Dallas, 2008. / Includes vita. Includes bibliographical references (leaves 90-91)

No description available.

Despite concern that preterm infants receive inappropriate tactile and auditory stimulation because of early birth, few studies have explored the development of responsiveness to tactile and auditory stimulation prior to 40 weeks' postconceptional age. The present research traced longitudinally the development of responsiveness to tactile and auditory stimulation of 14 preterm infants born at 30 or less weeks' postconceptional age. The preterm sample was divided into three groups (well, moderately ill, and sick) to assess the effects of illness. All infants were assessed three times per week from 30 to 34 weeks' postconceptional age. Body movement, eye movement, heart rate, smiles, hand-to-mouth activity, and "avoidance" signals of grimaces, cries, yawns, and tongue protrusions were assessed in response to (a) auditory stimulation in the form of talking, (b) tactile stimulation in the form of touching/stroking, and (c) the combination of talking and touching. Further, these infants were assessed weekly for the development of neurological reflexes and responsiveness to the orientation items from the Brazelton Neonatal Behavioral Assessment Scale. When a pre-stimulus period was compared to a stimulus condition, preterm infants were found to respond to talking with significantly more eye movement; to touching with significantly more body movement; and to the combination of talking and touching with more body movement. Significant effects of illness were found when smiles, hand-to-mouth activity, and "avoidance" signals were assessed. During all the stimulation conditions the well infants had significantly more smiles and hand-to-mouth activity. During talking and the combination of talking and touching the sick infants also showed significantly more "avoidance" signals. Sick infants also performed less well than the well infants on the Brazelton orientation items and on some of the neurological exam items. The findings of this study suggested that responsiveness to social stimuli, talking and touching, develops quite early, even before the time of usual birth, and is minimally affected by illness. Behaviors shown by these infants are those likely to attract the caregiver's attention, suggesting that the preterm infant is capable of behaviors which will engage the caregiver and possibly serve as the roots of social behavior. / This thesis was digitized as part of a project begun in 2014 to increase the number of Duke psychology theses available online. The digitization project was spearheaded by Ciara Healy.

No description available.

Thesis (D.N. Sc.)--Catholic University of America. / Typescript. eContent provider-neutral record in process. Description based on print version record. Bibliography: leaves 95-97.

Thesis (D.N. Sc.)--Catholic University of America. / Typescript. Bibliography: leaves 95-97.

Neuromodulatory systems, such as the locus coeruleus (LC) - norepinephrine (NE) system, are integral in the modulation of behavioral state, which in turn exerts a heavy influence on sensory processing, perception, and behavior. LC neurons project diffusely through the forebrain as the sole source of NE. LC tonic firing rate has been shown to correlate with arousal level and behavioral performance. As the LC-NE system innervates sensory pathways and NE has been shown to affect neuronal response, the LC-NE system could potentially allow for state-dependent modulation of sensory processing. However, the precise link between LC activation and sensory processing in the various stages of the sensory pathway that underly perception remained elusive. It is well established that thalamic relay nuclei play an essential role in gating the flow of sensory information to the neocortex, serving to establish cortical representation of sensory environment. Thalamocortical information transmission has been proposed to be strongly modulated by the dynamic interplay between the thalamic relay nuclei and the thalamic reticular nucleus (TRN). Neurons in the early stages of sensory pathways selectively respond to specific features of sensory stimuli. In the rodent vibrissa pathway, thalamocortical neurons in the ventral posteromedial nucleus (VPm) encode kinetic features of whisker movement, allowing stimuli to be encoded by distinctive, temporally precise firing patterns. Therefore, understanding feature selectivity is crucial to understanding sensory processing and perception. However, whether LC activation modulates this feature selectivity, and if it does, the mechanisms through which this modulation occurs, remained largely unknown. This work investigates LC modulation of thalamic feature selectivity through reverse correlation analysis of single-unit recordings from different stages of the rat vibrissa pathway. LC activation increased feature selectivity, drastically improving thalamic information transmission. This improvement was dependent on both local activation of α-adrenergic receptors and modulation of T-type calcium channels in the thalamus and was not due to LC modulation of trigeminothalamic feedforward or corticothalamic feedback inputs. LC activation reduced thalamic bursting, but this change in thalamic firing mode was not the primary cause of the improved information transmission as tonic spikes with LC stimulation carried three-times the information than tonic spikes without LC stimulation. Modelling confirmed NE regulation of intrathalamic circuit dynamics led to the improved information transmission as LC-NE modulation of either relay or reticular nucleus alone cannot account for the improvement. These results suggest a new sub-dimension within the tonic mode in which brain state can optimize thalamic sensory processing through modulation of intrathalamic circuit dynamics. Subsequent computational work was then performed to determine exactly how the encoding of sensory information by thalamic relay neurons was altered to allow for an increase in both information transmission efficiency and rate. The results show that LC-NE induced improvements in feature selectivity are not simply due to an increased signal-to-noise ratio, a shift from bursting to tonic firing, or improvements in reliability or precision. Rather, LC-NE-induced modulation of intrathalamic dynamics changed the temporal response structure thalamic neurons used to encode the same stimuli to a new structure that increased the information carried by both tonic and burst spikes. The shift in events times favors optimal encoding, as more events occur at ideal positions, i.e. when the stimulus most closely matches the neuron’s feature selectivity. Further, this work analyzed the ability to reconstruct the original stimulus using the evoked spike trains of multiple neurons and their recovered feature selectivity from an ideal observer point-of-view. The results showed that LC-activation improved the accuracy of this reconstruction, indicating it may improve the accuracy of perception of whisker stimuli. Finally, to make this work translatable, the use of vagus nerve stimulation (VNS) was investigated as a potential method for minimally invasive enhancement of thalamic sensory processing. The vagus nerve, which runs through the side of the neck, has long been known to have profound effects on brain-state and VNS has been shown to evoke LC firing. This work elucidates the previously uninvestigated short-term effects of VNS on thalamic sensory processing. Similar to direct LC stimulation, VNS enhanced the feature selectivity of thalamic neurons, resulting in a significant increase in the efficiency and rate of stimulus-related information conveyed by thalamic spikes. VNS-induced improvement in thalamic sensory processing also coincided with a decrease in thalamic burst firing, suggesting the same underlying mechanism as the improvements induced with direct LC stimulation.