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Preventing rapid platelet accumulation under very high shear stressPara, Andrea N. 21 May 2012 (has links)
Atherosclerosis is a major cause of mortality in industrialized nations. Atherosclerosis is characterized by plaque deposition which decreases the lumen diameter into a stenosis. The creation of a restriction increases shear rates pathologic levels exceeding 3,500/s. Following plaque cap rupture, thrombus may form from the accumulation of millions of platelets, occluding the vessel, leading to heart attack and stroke. Studies of high shear thrombosis show that platelet activation, GPIIb/IIIa and vWF are involved. However, some recent studies also suggest that high shear aggregation is not dependent on activation or GPIIb/IIIa. Several antiplatelet pharmaceuticals against activation
and GPIIb/IIIa have been proposed, but their efficacy in patients remains mixed. The overall
objective of this project is to determine the factors necessary for thrombosis to occlusion in very high shear regions seen in diseased arteries. Our central hypotheses are that platelet activation and the subsequent conformational change in GPIIb/IIIa are
necessary for thrombosis, and that higher concentrations of vWF in the plasma will
increase thrombosis.
To this end, we developed a new high shear hemodynamic model utilizing 30mLs of whole blood and quantified thrombus thickness, volume accumulation and accumulation rates. We demonstrate that thrombosis to occlusion stems from a second phase of Rapid Platelet Accumulation (RPA). Thrombus accumulation is completely prevented by PGE1 inhibition of platelet activation. Similarly, GPIIb/IIIa blockade via abciximab prevented significant thrombus deposition and RPA. We also found that
increasing plasma vWF levels in high shear regions increased thrombus thickness and
suggestively increased RPA rates. The results clarify the need for activation of mural
platelets for long term thrombus accumulation without the activation of circulating platelets.
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A comparative study of inclinometers and time domain reflectometry for slope movement analysisSargent, Lisa M. January 2004 (has links)
Thesis (M.S.)--Ohio University, March, 2004. / Title from PDF t.p. Includes bibliographical references (leaves 73-75).
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Study of rock joint roughness using 3D laser scanning techniqueTam, Chung-yan, Candy. January 2008 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2008. / Includes bibliographical references (leaf 147-154) Also available in print.
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Development of a new FRP anchor for externally bonded CFRP sheet/laminate to beams /Mostafa, Ahmed Abo El-Khair B. January 1900 (has links)
Thesis (M.App.Sc.) - Carleton University, 2005. / Includes bibliographical references (p. 184-188). Also available in electronic format on the Internet.
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Displacement-based seismic design of shear wall buildings /Pina Burgos, Freddy Eduardo, January 1900 (has links)
Thesis (M.App.Sc.) - Carleton University, 2006. / Includes bibliographical references (p. 194-206). Also available in electronic format on the Internet.
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Étude des propriétés mécaniques en cisaillement de la glace atmospherique /Bilodeau, Julien. January 1996 (has links)
Mémoire (M.Ress.S.)--Université du Québec à Chicoutimi, 1996. / Document électronique également accessible en format PDF. CaQCU
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Comportement mécanique d'une fracture en cisaillement : analyse par plan d'expériences des données mécaniques et morphologiques connues sur une fracture /Lopez, Philippe, January 2000 (has links)
Thèse (Ph.D.)--Université du Québec à Chicoutimi, 2000. / "...pour obtenir le grade de docteur de l'Université Bordeaux I - France et comme exigence partielle au philosophiae doctor de l'Université du Québec à Chicoutimi - Canada. Spécialité: mécanique" La thèse avec ses annexes sont accessibles via le curriculum vitae, section "COMMUNICATIONS". CaQCU CaQCU Document électronique également accessible en format PDF. CaQCU
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Punching shear strength of interior and edge column-slab connections in CFRP reinforced flat plate structures transferring shear and moment /Zaghloul, Ashraf, January 1900 (has links)
Thesis (Ph.D.) - Carleton University, 2007. / Includes bibliographical references (p. 351-372). Also available in electronic format on the Internet.
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Lubrication mechanisms and their influence on interface strength during installation of subsurface pipesMcGillivray, Catherine Black. January 2009 (has links)
Thesis (Ph.D)--Geosystems, Georgia Institute of Technology, 2010. / Committee Chair: Frost, J. David; Committee Member: Burns, Susan E.; Committee Member: Gokhale, Arun; Committee Member: Mayne, Paul W.; Committee Member: Rix, Glenn J. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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The analysis and design of adhesively bonded composite structuresRadice, Joshua J. January 2005 (has links)
Thesis (Ph.D.)--University of Delaware, 2006. / Principal faculty advisor: Jack R. Vinson, Dept. of Mechanical Engineering. Includes bibliographical references.
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