Publicación a texto completo no autorizada por el autor / Realiza propuestas de mejora para incrementar la productividad en el área de confecciones de una empresa de prendas de jean aplicando Six Sigma. Se emplea la metodología DMAIC de Six Sigma, por ello en la fase Definir se da una explicación mayor de la organización, para poder definir el problema. Se observa que una parte de confección denominada Moda es quien presenta la oportunidad de ser mejorada. En las etapa Medir se miden las eficiencias de Moda, su Lead Time, también las distancias que recorren los diversos productos. En la etapa de Análisis se determinaron cuáles son los factores que influyen las variables medidas en la anterior etapa y son tomadas en cuenta para que en una posterior etapa de la metodología DMAIC se proponga la implementación de la especialización de una parte de Confecciones Moda, además de un balance de línea con un enfoque modular para alcanzar la metas. Finalmente se propone una nueva distribución de planta que conlleva a reducir los traslados de las órdenes de producción. En la última etapa denominada Controlar se propone gráficas y formatos con los cuales se deben controlar los cambios propuestos para que de oportunidad a continuar con las mejoras en la organización. / Tesis

Publicación a texto completo no autorizada por el autor. / Evalúa el desempeño de los métodos automatizados empleados en el laboratorio de hematología del INEN utilizando la métrica Sigma. -Evaluar el desempeño de los métodos automatizados empleados para realizar el Recuento de leucocitos (WBC); Glóbulos rojos (RBC); Plaquetas (PQ), Hemoglobina (HB) y Hematocrito (HCT); en el laboratorio de hematología general del INEN durante el año 2012 al 2013, empleando como indicador la métrica Sigma. Asimismo, también evalúa el desempeño de los métodos automatizados empleados para realizar el tiempo de protrombina (TP); tiempo de tromboplastina parcialmente activada (TTPA); tiempo de trombina (TT); Fibrinógeno y Dímero D en el laboratorio de hematología general del INEN durante el año 2012 al 2013, empleando como indicador la métrica Sigma. Finalmente, determina el Error Sistemático Crítico (ESC) a partir del desempeño obtenido para las metodologías automatizadas empleadas en el laboratorio de Hematología general del INEN. / Tesis

Plantea la implementación del enfoque Lean Six Sigma en el proceso de fabricación de zunchos de polipropileno, con la finalidad de enfocar el producto en los requerimientos del cliente y reducir los desperdicios del proceso. Utiliza la metodología DMAIC. Realiza el diagnóstico del proceso, identifica a los clientes y los CTQ’s, finalmente determina con Y de mejora el porcentaje de mediciones del zuncho de polipropileno. Mapea el proceso detalladamente para identificar las variables relacionadas directamente con el CTQ. Selecciona las variables velocidad del conjunto de 05 rodillos jaladores, velocidad del conjunto de 03 rodillos jaladores y velocidad de rodillo de salida. Evalúa los roles que asumirían los trabajadores de la empresa y aplica un test sobre las competencias del líder del proyecto, del facilitador y de la organización. Evalúa las oportunidades Lean en el proceso. Identifica los principales desperdicios del proceso y selecciona como críticos los movimientos innecesarios y las esperas. Detecta que los desperdicios se generan mayormente en la actividad de cambio de malla. Presenta planes de mejora para la implementación de la metodología propuesta. / Trabajo de suficiencia profesional

Magister Educationis - MEd / The current study framed as, ‘Emerging Technologies for Teaching and Learning: An Investigation into the Role and Use Of iPads In English Second Language in Three Primary Schools in Northern Zambia,’ is situated in Northern Zambia in the Mungwi District. The study set out to investigate the role and use of emerging technology/-ies that is iPads, for literacy development in Grade six English Second Language schools. The purpose was to gain insight into the role emerging technologies play in fostering English Second Language (ESL) and literacy development in the era of new multimodal texts. This entailed acquiring an understanding of how highly ZeduPad tablets might facilitate meaning-making in the process of developing literacy skills.

Sponges are the descendants of the oldest members of the metazoan phylogenetic lineage and their genome contains animal specific genes but lack true tissues, organ systems, and neurons. Thus, the sponge model system can be used to elucidate origin of developmental processes. The PSED (RDGN) network (Pax/Six/Eya/Dac) is important in development of eyes, muscles, and other structures in Bilaterians. Similarly, sponges contain a precursor Pax-Six gene network. The Ephydatia muelleri (Em) PaxB protein binds to a Pax2/5/8 consensus sequence site and two cis-regulatory elements upstream and one intron sequence of EmSix1/2 (Rivera et al., 2013). This study aimed to determine if transcription factor EmSix1/2 binds upstream of EmPaxB using gel shift mobility assays, identify other downstream targets of EmSix1/2 using DNA immunoprecipitation, and to identify the recognition sequence of Six in sponges through sequencing. In conclusion, purified EmSix binds to DNA specific fragments (1 and 3), which may contain enhancer sequences located in the PaxB promoter region.Possible consensus recognition sequence of Six in sponges were also identified. The host immune response has various mechanisms to protect the organism from infections and invasions of microorganisms and cell damaging chemicals. One such mechanism is the elimination of reactive oxygen species aided by superoxide dismutase (SOD). A study showed that anti-neutrophil chemotactic factor antibodies recognize Tritrichomonas foetus SOD (Granger et al., 1997). During first casualties, SOD is released and triggers a host immune response. The parasites could use SOD to counter oxidative attacks by the leukocytes and damaged cells to protect surrounding parasites. We used the parasite Trichomonas vaginalis that causes trichomoniasis to determine if SOD acts a neutrophil (or other leukocyte) chemotactic factor in this parasite and characterize the expression and secretions of epithelial cells when treated with SOD6. HeLa cells treated with SOD6 showed an increase in the expression of IL-8 chemokine relative to TrxR treated cells. Scratch test assays showed that SOD may act as a macrophage chemoattractant as compared to TrxR but further tests are needed to confirm this.

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第21779号 / 工博第4596号 / 新制||工||1716(附属図書館) / 京都大学大学院工学研究科材料化学専攻 / (主査)教授 松原 誠二郎, 教授 中尾 佳亮, 教授 杉野目 道紀 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DFAM

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I collaborate with Elders of the Six Nations of the Grand River Territory – mainly former vice-principals and principals – to share their stories about elementary school administration of the community’s day schools of the 1960s, 70s, and 80s, and of the larger consolidated schools thereafter. By engaging in storywork with them, their stories reveal that as Indigenous organizations like the National Indian Brotherhood/Assembly of First Nations (NIB/AFN) warned First Nations about mistaking administrative control, or delegated authority as it framed it, as real, local control over their children’s education, vice-principals and principals in Six Nations reframed it as inherent acts of self-determination and sovereignty over education. Drawing on Audra Simpson’s nested sovereignty, and Glen Sean Coulthard’s self-recognition to produce a more accurate representation of administrative control in the community, the author argues that vice-principals and principals in Six Nations did not mistake their practice as delegated authority but instead – as inherently sovereign actors – went through a process of negotiating self-determination and sovereignty within the Department of Indian Affairs and Northern Development Canada’s (DIAND) educational framework to upset its status quo of First Nations only managing educational programs and services. If sovereignty is understood to be a process, rather than a destination as Robert Allen Warrior suggests, then vice-principals and principals exercising administrative control on a daily basis in their schools should be recognized as inherently self-determining and sovereign. By sharing their stories, they reveal that they possess the authority to determine the definition and character of administrative control at the local level. The argument’s implication being that there are alternative ways of knowing and understanding administrative control in First Nations schools, rather than the national discourse that evolved in the decades following the NIB’s Indian Control of Indian Education. / Thesis / Master of Arts (MA) / I collaborate with Elders of the Six Nations of the Grand River Territory – mainly former vice-principals and principals – to share their stories about elementary school administration of the community’s day schools of the 1960s, 70s, and 80s, and of the larger consolidated schools of the 1990s and early 2000s. By engaging in storywork with the Elders, their stories reveal that as Indigenous organizations like the National Indian Brotherhood/Assembly of First Nations (NIB/AFN) warned First Nations communities about mistaking administrative control, or delegated authority as it framed it, as real, local control over their children’s education, vice-principals and principals in Six Nations reframed it as inherent acts of self-determination and sovereignty over education. Their stories provide an alternative way of knowing and understanding administrative control in First Nations schools.

Although water covers 70% of the earth's surface, less than 1% of it is freshwater that can be used for drinking. Even in Canada, where there is an abundance of freshwater in groundwater and in rivers and lakes, there are many indigenous communities that lack a sustainable source of drinking water. Such is the case for the Six Nations of the Grand River, the largest indigenous Reserve in Canada, located within an hour drive from major urban centers in southern Ontario and where less than 9% of the residents have access to safe, treated potable water. The major tributaries that drain the Six Nations reserve are part of the McKenzie Creek Watershed, which has been characterized as having the highest loading of sediments and nutrients to the lower Grand River, which eventually drains into the eastern basin of Lake Erie. This research project was initiated by the Six Nations community, who wanted an update on the prevalence of fecal contamination in their drinking water sources (wells, cisterns). Secondly, the community wanted to know the ecosystem health status of tributaries flowing through the Six Nations Reserve (McKenzie and Boston Creeks), and to determine if land uses in the watershed were negatively affecting the health of these streams. A study conducted in the summer of 2018 confirmed that 29% of the tap water tested in 75 households were contaminated with E. coli; 40% of the wells and 15% of the cisterns were contaminated and these were distributed throughout the Reserve with no apparent pattern. A study conducted in the summer of 2019 found that the McKenzie Creek was highly polluted with total phosphorus (P), total suspended solids, turbidity and total-ammonia nitrogen (N), while Boston Creek was highly polluted with soluble reactive P and E. coli as well as total-nitrate N. Nitrogen concentrations at 14 stations were highly and significantly related to percentage of agricultural land in catchments. Elevated levels of pollutants have been observed in the two creeks for three decades, indicating that conditions will not improve without remedial actions. / Thesis / Master of Science (MSc)

The main purpose of this thesis work was to halve the cycle time of a grinding process of the groove of carbonitrided ball bearings rings. The study was conducted as a Six Sigma project at SKF in Bari, Italy. Reaching the goal was important for the company as it meant avoiding the purchase of another grinding machine. The groove grinding process on carbonitrided rings features double the cycle time than the same process on through hardened rings and halving it was required to fulfill the volumes demanded. The Six Sigma methodology was applied through the implementation of DMAIC. The analysis of the problems and identification of areas for improvement were carried out deploying different tools such as an Ishikawa diagram, Hypothesis Testing and Statistical Process Control. The outcome of this was the need to optimize the carbonitriding process minimizing the depth of the layer without enlarged carbides in order to render the design of the part easier to machine and subsequently find the process parameters for the groove grinding yielding a cycle time of six seconds. Many trials were conducted with the supplier of carbonitriding, until the carbon and ammonia potentials were set at levels resulting in a depth of the layer allowing the change of the design. An optimizing DOE was instead performed for the grinding process which highlighted the parameters settings yielding the target cycle time. Finally actions and controls to perform in order to maintain the gains were defined.