Tobacco use is closely related to changes in body weight. Undesired weight gain following smoking cessation occurs in most patients. The mechanism responsible for changes in body weight post cessation are only partially understood. Several hypotheses have suggested a temporary increase in blood pressure following smoking cessation. In addition, weight concerns after quitting are common, and may affect tobacco dependence treatment outcomes. The aim of our study was to monitor changes in body weight, blood pressure, incretins and selected hormonal parameters among ex-smokers after three months of abstinence. We also examined factors associated with smoking-related weight concerns. We monitored and evaluated selected parameters (personal history, questionnaires, anthropometric, biochemical, hormonal) and compared before and after tobacco dependece treatment, if patients underwent such treatment. We found that smoking cessation was associated with weight gain. Smokers who were more tobacco dependent or more sedentary were at increased risk. The prevalence of diagnosis hypertension did not differ among non-smokers, former smokers and smokers adjusting for age and BMI. In the pilot phase of our study we demonstrated that three months of smoking abstinence was associated with an increase in serum leptin...

Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-06-06T15:58:37Z No. of bitstreams: 1 henriquepintogomide.pdf: 4886533 bytes, checksum: ebecd2fd03722fac5b23835abb7cf2d9 (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-07-02T13:29:17Z (GMT) No. of bitstreams: 1 henriquepintogomide.pdf: 4886533 bytes, checksum: ebecd2fd03722fac5b23835abb7cf2d9 (MD5) / Made available in DSpace on 2016-07-02T13:29:17Z (GMT). No. of bitstreams: 1 henriquepintogomide.pdf: 4886533 bytes, checksum: ebecd2fd03722fac5b23835abb7cf2d9 (MD5) Previous issue date: 2014-02-10 / Intervenções para tabagismo mediadas por internet disponíveis em língua portuguesa não cobrem todos os conteúdos das diretrizes de tratamento do tabagismo. Não existem intervenções de código-aberto na internet, isto é, que divulgam todo o código-fonte para sua adaptação e replicação para outros contextos e populações. O objetivo do estudo foi descrever uma metologia de desenvolvimento e avaliar a intervenção para tabagismo mediada por internet de código-aberto - “Viva sem Tabaco”. O desenvolvimento aconteceu nas seguintes etapas:(1) desenvolvimento do protótipo, (2) realização de um grupo focal fumantes e correção do protótipo e (3) avaliação da cobertura, precisão e interatividade do conteúdo com base nos 12 componentes das diretrizes de tratamento para tabagismo, e (4) revisão do conteúdo. Com os resultados do grupo focal e na revisão teórica das diretrizes, o protótipo foi desenvolvido e corrigido. Após as correções, o protótipo foi avaliado pelos especialistas e corrigido. O conteúdo da intervenção foi avaliado por dois pesquisadores de forma independente, 9 dos 12 tópicos apresentaram cobertura considerada adequada e 3 com cobertura mínima. Quanto à precisão, 8 tópicos foram avaliados como corretos e 4 como maior parte correto. Dois dos 12 tópicos apresentaram interatividade. Após a avaliação, a intervenção foi corrigida. A versão final da intervenção desenvolvida apresentou convergência com as diretrizes de tratamento. Estudos devem ser conduzidos para avaliar a eficácia da intervenção. / Web-assisted tobacco interventions (WATI) in Portuguese do not cover the standard guidelines for smoking treament and lack content quality. Current web-assisted tobacco interventions are not open-source, which reduce the development speed in developing countries. The objective of this study was to describe a development methodology of a open-source WATI and evaluate its quality. The development comprised the following stages: (1) prototype development, (2) assessment of the prototype using focus groups, and (3) content coverage, accuracy and interactivity evaluation using as reference the guideline “Treating tobacco use and depedence - 2008 update”, and (4) final review. Based on the data from focus groups and content review, the initial prototype was redesigned. The content evaluation, performed independently by two specialists, showed that 9 of 12 components were well covered and 3 minimally covered. Eight of 12 components were classified as correct and 4 as mostly correct. Just two topics were considered interactive. Based on the evaluation, a final review was conducted in the intervention content. The developed intervention was compliant with tobacco treatment guidelines, providing an evidence based guide for smokers who seek help over the internet. Future studies should address the clinical efficacy of the developed intervention.

Indiana University-Purdue University Indianapolis (IUPUI) / Smoke-free legislation in the United States has unintentionally resulted in a decline in alcohol consumption. However, more recently electronic-cigarettes (e-cigs), which are associated with alcohol use, are reportedly being used to circumvent smoking bans. The present study surveyed community dwelling individuals in the United States reporting e-cigs may be used where they drink (N=365, mean age=33.63, SD=9.91, 53.2% female, 78.9% Caucasian) to examine how e-cig use and alcohol consumption varies by the presence of smoking prohibition where one consumes alcohol. Results indicated that smoking prohibition was associated with a greater likelihood of being an ecig user than a cigarette user (OR=3.40, p<.001) and a higher likelihood of being an e-cig user than a dual user (OR=3.37, p<.001). Smoking prohibition was not associated with AUDIT scores (B=-0.06, p=.21), total drinks (B=-.07, p=.19), or average drinks (B=-0.02, p=.76). E-cig users reported significantly fewer average drinks when smoking is prohibited as compared to allowed, t(55)=3.26, p=.002. Overall, current results suggest smoking prohibition is associated with a greater likelihood of being an e-cig user; however, smoking prohibitions are not associated with alcohol consumption and related problems in the current participants, who all reported being able to use e-cigs where they consume alcohol. Future research should address potential conceptual, methodological, and sample limitations in order to better discern this relationship, as this line of research could have important implications for e-cig policy and alcohol use treatment

Indiana University-Purdue University Indianapolis (IUPUI) / The impact of tobacco smoking on human health is well documented. The influence of smoking on tooth loss and cardiovascular diseases was investigated in the current study via both epidemiology and in vitro studies. From analyzing the 2006 Behavioral Risk Factor Surveillance System (2006 BRFSS) database, we confirmed that smoking was significantly associated with the number of teeth lost in a dose-dependent manner and smoking cessation reduced the risk when compared to those subjects continuing to smoke. In addition, the virulence factors related to caries were compared between Streptococcus mutans and Streptococcus gordonii in response to cigarette smoking condensate (CSC) treatment. We observed that S. gordonii was more susceptible to CSC treatment than S. mutans. CSC significantly enhanced S. mutans sucrose-dependent and independent adherence. Western blot assays revealed that several bacterial surface proteins including glucosyltransferase (GTF), glucan-binding proteins and antigen I/II, were significantly upregulated for the treated S. mutans. These findings suggested that the oral environment with CSC may favor a cariogenic dominant composition, which may increase the risk for smokers to develop caries. We also found that smoking and oral health status modified each other and synergistically increased the risk of CVD and this joint effect was more pronounced among the youngest age group using the 2006 BRFSS database. To further understand the joint effect, we conducted an in vitro study to investigate bacterial attachment to fibronectin and endothelial cells in response to smoking condensate treatment. Our study clearly demonstrated CSC significantly enhanced S. mutans attachment to both soluble and immobilized fibronectin as well as endothelial cells. Furthermore, our data suggested that bacteria possessed several adhesins that bound to host tissues and endothelial cells also had multiple receptors for bacterial attachment. Among these adhesins, antigen I/II seemed essential for bacterial attachment to endothelial cells without CSC. The knowledge of bacterial attachment to host tissues in the presence of CSC may help in developing different preventive or therapeutic strategies against attachment and colonization of the host by S. mutans.

No description available.

Background: Cigarette smoking is a leading preventable factor associated with complications in pregnancy including preterm birth and low birthweight. Past interventions have raised cessation rates by approximately 6% overall (Lumley et al. 2009). Methods: A three-part literature review, two qualitative studies with a total of 36 participants, and the development of an intervention to promote smoking cessation during pregnancy were completed. Central to the design of the research was the creation of the theoretical basis which was developed in line with recommendations from the MRC Framework for Complex Interventions (Craig et al. 2008, Campbell et al. 2000). For part one of the literature review, 24 qualitative and 44 quantitative studies were re-analysed to complete a mixed-methods secondary analysis of the active ingredients in interventions to promote smoking cessation during pregnancy. Part two consisted of an exploration of psychological models and constructs which are likely to predict or influence smoking behaviour during pregnancy. The final part was a discussion regarding the modes of delivery by which an intervention could feasibly be delivered. Qualitative interviews were carried out with participants from stakeholder groups to fill in gaps in literature and determine the acceptability and feasibility of the proposed intervention. The intervention was created using the theoretical basis developed from the findings. Further qualitative interviews, a focus group, and heuristic evaluation were used to determine the acceptability and usability of the intervention for the target group of pregnant smokers. Results and Conclusions: Findings from this work are potentially relevant for a wide range of behaviours and behavioural interventions. An intervention which has a strong grounding in theory and evidence, and is acceptable and feasible for the target group and in clinical practice was developed using evidence gathered in this thesis.

Realizou-se estudo exploratório de revisão bibliográfica sistemática e metassíntese visando descrever e analisar aspectos das práticas educativas em saúde, voltados ao desenvolvimento de habilidades para a cessação do tabagismo, traduzidas na interpretação de autores de pesquisas qualitativas publicadas em periódicos entre 2000 e 2007. Concebeu-se a questão do tabagismo como um problema de enfrentamento complexo, que demanda intervenções em vários âmbitos. Destacou-se a educação em saúde, como campo estratégico e instrumental da promoção da saúde, que sob a perspectiva do \"empowerment\" e \"empowerment education\", é passível de atuação do profissional de saúde. Utilizando-se do instrumental metodológico da metassíntese qualitativa, descrito por Sandelowski e Barroso (2003), identificou-se a produção científica de pesquisas qualitativas originais sobre experiências relativas às práticas educativas na cessação do tabagismo, indexadas nas bases de dados eletrônicas MEDLINE, CINAHL e LILACS. Para tanto utilizou-se os descritores pesquisa qualitativa, educação em saúde e tabagismo, além de descritores de texto livre e palavras com truncamento, visando a identificação ampliada de artigos que pudessem ser relevantes. Mapeou-se os artigos selecionados para a amostra bibliográfica segundo suas características gerais, aplicando-se os critérios de qualidade, dados pelo instrumento \"Critical Appraisal Skills Programme, CASP\" (© Milton Keynes Primary Care Trust, 2002). Os resultados desta produção foram integrados através da análise de conteúdo descrita por Minayo (2004), de modo a buscar temas relacionados à educação em saúde, aos quais foram combinados atributos (ou sub-temas). A busca bibliográfica resultou na identificação de 989 citações nessa temática, das quais 634 foram consideradas relevantes. Após seleção com base na leitura do título, a seguir dos abstracts (340) e por fim dos artigos na íntegra (88), foram classificadas 14 publicações como pertinentes para este estudo. Na metassíntese os aspectos recorrentes e as diferenças entre os artigos foram agrupados em duas modalidades temáticas: contexto dos sujeitos (descrevendo os fatores facilitadores e dificultadores do processo de cessação do tabagismo) e abordagem educativa (com processos facilitadores e dificultadores dos programas de cessação do tabagismo e da relação profissional-paciente apresentados em quadro temático, com comentários). As estratégias de abordagem do processo educativo foram classificadas com base nos elementos da promoção da saúde e nos modelos educacionais. Conclui-se que a metassíntese apresenta-se como metodologia relevante no âmbito da enfermagem (que tem vasta produção de pesquisa qualitativa), pois favorece análises e interpretações com potencial de proporcionar visibilidade e impacto no processo de cuidar e ser cuidado, fornecendo elementos para tomada de decisão. A compreensão sobre temas relacionados às abordagens educativas em saúde, nos processos de cessação do tabagismo, e o seu significado para os pacientes foi ampliada / An explorative systematic bibliographic review and meta-synthesis was realized looking to describe and analyze aspects of the educational practices in health, directed to the development of abilities for the smoking cessation, translated through the interpretation of the authors of the qualitative researches published in journals from 2000 to 2007. The smoking question was identified as a complex approach problem, which requires interventions from various aspects. Health education was emphasized, which under the perspective of the empowerment and empowerment education, is liable to the performance of the health professional. Using the qualitative meta-synthesis instrumental method described by Sandelowski and Barroso (2003), it was possible to identify a scientific production of primary qualitative researches about educational practices in the smoking cessation, indexed in MEDLINE, CINAHL and LILACS databasis. For this was used qualitative research controlled vocabulary, health education and smoking, besides the free texts and words with truncation, looking to increase the identification of the studies that may be relevant. The selected studies were identified according to its general characteristics, having been applied quality criterias supplied by the \"Critical Appraisal Skills Programme, CASP\" (© Milton Keynes Primary Care Trust, 2002) instrument. The results of this production were integrated through the analysis of content described by Minayo (2004), in order to look for themes related to health education, of which had attributes (sub-themes) combined to them. The bibliographic research resulted in the identification of 989 citations about this theme, where 634 were considered relevant. After the selection based on the title of the studie, following the abstracts (340) and finally of the reading of 88 complete studies, 14 publications were classified as being pertinent to this study. In the meta-synthesis the reoccurring aspects and the differences between the studies were separated in two types of themes: context of the subjects (describing the facilitating and difficulting facts of the smoking cessation process) and education approach (with facilitating and difficulting processes of the smoking cessation programs and of the patient-professional relationship presented in a theme board, with comments). The strategies used in the educational processes were classified based on the elements of the health promotion and on educational models. We conclude that the meta-synthesis presents itself as a relevant methodology in nursing environment (which provides vast qualitative research productions), because it helps in analysis and interpretations with the potential of facilitating visibility and impact in the process of taking care and being taken care of, supplying elements for decision making. The comprehension about themes related to health educational approaches, in the smoking cessation processes, and its meaning to patients, has been increased

Introdução: O tabagismo é um problema crônico e de enfrentamento complexo. A ampliação da legislação, a conscientização da sociedade e a menor aceitação social do tabagismo, aumentaram a procura por serviços de cessação do tabagismo. A avaliação de programas desse tipo é tarefa complexa, considerando os diferentes níveis de intervenção, a diversidade de cenários e atores envolvidos. A avaliação de programas de cessação do tabagismo necessita incorporar ferramentas participativas, capazes de apontar a eficiência do programa, além de fomentar ações de transformação das práticas. Esta pesquisa buscou configurar uma matriz avaliativa capaz de contribuir na organização e autoaprendizagem de serviços dirigidos aos sujeitos em suas tentativas de parar de fumar, captando os diferentes contextos presentes na intervenção, nos cenários e nos atores. As questões da pesquisa foram: Quais são os indicadores que podem apontar o quanto um serviço se aproxima ou se distancia das práticas baseadas em evidências e dos modelos e diretrizes da promoção da saúde? Quais são os elementos que indicam ou não a qualidade de um serviço de tratamento do tabagismo? Objetivos: Desenvolver a matriz de indicadores de um serviço de tratamento do tabagismo. Para tanto buscou-se a) Identificar a percepção de experts, usuários e profissionais sobre serviços de tratamento do tabagismo; b) Caracterizar as práticas e bases de um serviço de cessação do tabagismo; c) Construir o modelo lógico avaliativo desse serviço; c) Formular as bases teóricas e práticas para a construção de matriz avaliativa de indicadores para um serviço de tratamento do tabagismo. Método: Situado no desenho orientado por modelo teórico (theory-driven evaluation) na perspectiva da Promoção da Saúde preconizada por Hartz, o percurso metodológico foi apoiado nas abordagens qualitativas e participativas e na estratégia da pesquisa-ação. O cenário de estudo foi o serviço de cessação do tabagismo de um hospital universitário, no município de São Paulo. Foram sujeitos dessa pesquisa profissionais de referência para o PNCT (experts), profissionais que atuam diretamente no serviço (implicados) e usuários do serviço. A análise e discussão dos achados apoiaram-se na triangulação de dados, correlacionada com a literatura. Resultados: O desfecho desta pesquisa foi o desenvolvimento da matriz avaliativa. Utilizou-se as percepções dos experts, implicados e usuários sobre as dimensões de estrutura, processo e resultado. A legislação, o financiamento, extensão e cobertura, a acessibilidade, as instalações, os recursos humanos, os equipamentos e insumos foram apontados como categorias para estrutura. Na dimensão processo as categorias foram: divulgação e captação, acolhimento e busca ativa, o perfil sócio psicológico dos usuários, a rede de referência e contra referência, o diagnóstico, acompanhamento e as estratégias educativas com base no autocuidado e na redução de danos. No âmbito de resultados os sujeitos pontuaram: a taxa de sucesso na cessação do tabagismo, a regularidade do serviço, a adesão, o respeito à autonomia, a melhora na qualidade de vida e a satisfação do usuário. Conclusão: Conclui-se que a matriz avaliativa construída possui potencial para avaliar a qualidade do serviço e promover o aprendizado institucional e o desenvolvimento pessoal/profissional. Contribui para o movimento de reflexão-ação-reorientação das práticas de cuidado. Ao ampliar a análise para além dos importantes indicadores solicitados pelo Programa Nacional do Controle do Tabagismo, a matriz elaborada dirige-se ao fortalecimento (empowerment) dos envolvidos (profissionais e usuários). Ajuda a estabelecer papéis e responsabilidades na reorientação de aspectos que possam influenciar o desempenho no acesso, acolhida, diagnóstico, tratamento e acompanhamento dos que desejam parar de fumar. / Introduction: Tobacco smoking is a chronic problem and very difficult to face. The improvements in the legislation, the awakening of the society and the smaller social acceptance to tobacco smoking have increased the number of people looking for smoking cessation services. The evaluation of such programs is a complex task, considering the different levels of intervention and the diversity of sceneries and actors involved. The evaluation of smoking cessation programs needs to incorporate participatory tools in order to indicate the program efficiency, and foster transformation actions of the practices. This study sought to configure an evaluation framework capable of contributing to the organization and self-learning of the services addressed to individuals in their attempts to quit smoking by capturing the different contexts present in the intervention sceneries and actors. The research questions were: Which are the indicators that may point out how much a service comes close or is distant from evidence-based practices, guidelines and models of health promotion? Which are the elements that indicate or not the quality of a smoking cessation treatment service? Objective: Developing the indicators framework of a smoking cessation service. For this it was sought to a) identify the experts, users and professionals perceptions about smoking cessation services, b) Characterize the practices and basis for a smoking cessation service c) Build the evaluative logical model of such service c) Formulate the theoretical and practical basis for the construction of an evaluative framework of indicators for a smoking cessation service. Method: Situated in the theoretical model oriented design (theory-driven evaluation) from the perspective of health promotion proposed by Hartz, the methodological trajectory was based on the qualitative and participative approaches as well as in the strategy of the action research. The study setting was the smoking cessation service at a university hospital in São Paulo. The subjects of this study were reference for the NTCP professionals (experts), the professionals who work directly in the service (stakeholders) and service users. The analysis and discussion of the findings were based upon the triangulation of data, correlated with the literature. Results: The outcome of this research was the development of the evaluation framework. It was used the perceptions of experts, and users concerned about the dimensions of structure, process and outcome. The legislation, funding, the extension and coverage, accessibility, facilities, human resources, equipment and supplies were identified for \"structure\". In the dimension \"process\" the categories were: dissemination and uptake, host and active search, the social psychological profile of the users, the network of reference and cross reference, diagnosis, monitoring and educational strategies based on self-care and harm reduction. Within the scope of \"outcomes\" the subjects pointed: the success rate of stop smoking, the regularity of service, treatment adherence, the autonomy, the improvement in quality of life and user satisfaction. Conclusions: We conclude that the evaluative framework constructed has the potential for assessing the service quality and to promote institutional learning and personal / professional development. It contributes to the movement of the reflection-action-reorientation of care practices. By broadening the analysis beyond the important indicators requested by the National Tobacco Control Program, the elaborate framework is targeted to the empowerment of those involved (professionals and patients). It helps to set roles and responsibilities in reorienting the aspects that may influence the access, reception, diagnosis, treatment and monitoring performance of those who want to quit smoking.

Realizou-se estudo exploratório de revisão bibliográfica sistemática e metassíntese visando descrever e analisar aspectos das práticas educativas em saúde, voltados ao desenvolvimento de habilidades para a cessação do tabagismo, traduzidas na interpretação de autores de pesquisas qualitativas publicadas em periódicos entre 2000 e 2007. Concebeu-se a questão do tabagismo como um problema de enfrentamento complexo, que demanda intervenções em vários âmbitos. Destacou-se a educação em saúde, como campo estratégico e instrumental da promoção da saúde, que sob a perspectiva do \"empowerment\" e \"empowerment education\", é passível de atuação do profissional de saúde. Utilizando-se do instrumental metodológico da metassíntese qualitativa, descrito por Sandelowski e Barroso (2003), identificou-se a produção científica de pesquisas qualitativas originais sobre experiências relativas às práticas educativas na cessação do tabagismo, indexadas nas bases de dados eletrônicas MEDLINE, CINAHL e LILACS. Para tanto utilizou-se os descritores pesquisa qualitativa, educação em saúde e tabagismo, além de descritores de texto livre e palavras com truncamento, visando a identificação ampliada de artigos que pudessem ser relevantes. Mapeou-se os artigos selecionados para a amostra bibliográfica segundo suas características gerais, aplicando-se os critérios de qualidade, dados pelo instrumento \"Critical Appraisal Skills Programme, CASP\" (© Milton Keynes Primary Care Trust, 2002). Os resultados desta produção foram integrados através da análise de conteúdo descrita por Minayo (2004), de modo a buscar temas relacionados à educação em saúde, aos quais foram combinados atributos (ou sub-temas). A busca bibliográfica resultou na identificação de 989 citações nessa temática, das quais 634 foram consideradas relevantes. Após seleção com base na leitura do título, a seguir dos abstracts (340) e por fim dos artigos na íntegra (88), foram classificadas 14 publicações como pertinentes para este estudo. Na metassíntese os aspectos recorrentes e as diferenças entre os artigos foram agrupados em duas modalidades temáticas: contexto dos sujeitos (descrevendo os fatores facilitadores e dificultadores do processo de cessação do tabagismo) e abordagem educativa (com processos facilitadores e dificultadores dos programas de cessação do tabagismo e da relação profissional-paciente apresentados em quadro temático, com comentários). As estratégias de abordagem do processo educativo foram classificadas com base nos elementos da promoção da saúde e nos modelos educacionais. Conclui-se que a metassíntese apresenta-se como metodologia relevante no âmbito da enfermagem (que tem vasta produção de pesquisa qualitativa), pois favorece análises e interpretações com potencial de proporcionar visibilidade e impacto no processo de cuidar e ser cuidado, fornecendo elementos para tomada de decisão. A compreensão sobre temas relacionados às abordagens educativas em saúde, nos processos de cessação do tabagismo, e o seu significado para os pacientes foi ampliada / An explorative systematic bibliographic review and meta-synthesis was realized looking to describe and analyze aspects of the educational practices in health, directed to the development of abilities for the smoking cessation, translated through the interpretation of the authors of the qualitative researches published in journals from 2000 to 2007. The smoking question was identified as a complex approach problem, which requires interventions from various aspects. Health education was emphasized, which under the perspective of the empowerment and empowerment education, is liable to the performance of the health professional. Using the qualitative meta-synthesis instrumental method described by Sandelowski and Barroso (2003), it was possible to identify a scientific production of primary qualitative researches about educational practices in the smoking cessation, indexed in MEDLINE, CINAHL and LILACS databasis. For this was used qualitative research controlled vocabulary, health education and smoking, besides the free texts and words with truncation, looking to increase the identification of the studies that may be relevant. The selected studies were identified according to its general characteristics, having been applied quality criterias supplied by the \"Critical Appraisal Skills Programme, CASP\" (© Milton Keynes Primary Care Trust, 2002) instrument. The results of this production were integrated through the analysis of content described by Minayo (2004), in order to look for themes related to health education, of which had attributes (sub-themes) combined to them. The bibliographic research resulted in the identification of 989 citations about this theme, where 634 were considered relevant. After the selection based on the title of the studie, following the abstracts (340) and finally of the reading of 88 complete studies, 14 publications were classified as being pertinent to this study. In the meta-synthesis the reoccurring aspects and the differences between the studies were separated in two types of themes: context of the subjects (describing the facilitating and difficulting facts of the smoking cessation process) and education approach (with facilitating and difficulting processes of the smoking cessation programs and of the patient-professional relationship presented in a theme board, with comments). The strategies used in the educational processes were classified based on the elements of the health promotion and on educational models. We conclude that the meta-synthesis presents itself as a relevant methodology in nursing environment (which provides vast qualitative research productions), because it helps in analysis and interpretations with the potential of facilitating visibility and impact in the process of taking care and being taken care of, supplying elements for decision making. The comprehension about themes related to health educational approaches, in the smoking cessation processes, and its meaning to patients, has been increased

No description available.