Thesis (M.Sc.)--York University, 2009. Graduate Programme in Kinesiology and Health Science. / Typescript. Includes bibliographical references (leaves 76-87). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR51561

Senior Honors thesis--Regis University, Denver, Colo., 2009. / Title from PDF title page (viewed on Jun. 16, 2009). Includes bibliographical references.

Thesis (M.S.)--Brigham Young University. Dept. of Physiology and Developmental Biology, 2007. / Includes bibliographical references (p. 33-47).

Thesis (Ph. D.)--University of Texas at Austin, 2008. / Vita. Includes bibliographical references.

Mother-infant separation (MS) is an early-life stressor which affects stress-related processes in brain and behaviors in rats. Changes associated with MS were investigated in the brain and behavior of two rat strains, Holtzman and Sprague-Dawley, at three points in development. The hypothesis was that MS would affect the prefrontal cortex (PFC), both in metabolic capacity and PFC-related behaviors across the lifespan. First, cytochrome oxidase (CO), an enzyme that directly reflects metabolic capacity in the brain, was quantified in two-week old Holtzman rats after MS, early handling (EH), or nohhandled controls. MS reduced CO activity in the PFC of female rats but not males. Path analysis of the CO data revealed a stronger descending influence of the medial PFC, a region associated with behavioral inhibition, in females; contrasted with a stronger descending influence of the lateral PFC, a region associated with motor output, in males. Second, adolescent rats were tested in the open field to assess MS effects on ambulatory activity and impulsivity. MS increased ambulatory activity and impulsivity in Sprague-Dawley males. In a separate study, MS reduced ambulation and impulsivity in Holtzman rats in the open field. Brains of Sprague- Dawley adolescents showed reduced PFC thickness in MS males relative to EH males. Across groups, male adolescents had reduced metabolic capacity relative to females in the PFC. Finally, extinction of Pavlovian fear, a PFC-related behavior, was not affected by sex or separation group in adult Holtzman rats. Across groups, males showed greater fear renewal than females, despite the extinction process. An unexpected finding was that EH attenuated fear renewal. Findings from these MS studies in Sprague-Dawley rats are similar to human psychopathology of ADHD, which is reported more frequently in young males and is related to PFC dysfunction. The opposite behavioral findings between Holtzman and Sprague-Dawley rats suggest that genetic predisposition can affect long-term responses to the same early-life stressor. Knowledge about baseline sex differences in brain and behavior gained from the studies on Holtzman rats may help future research to consider sex-dependent effects of disruptions during development, as it appears that some basic neural substrates are sexually dimorphic. / text

The aim of the present study was to develop an alternative non-obese non-genetic rat model of type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Caffeine 5 mg/kg BW + STZ (CAF5), Caffeine 10 mg/kg BW + STZ (CAF10), Caffeine 20 mg/kg BW + STZ (CAF20) and Caffeine 40 mg/kg BW + STZ (CAF40) and were fed a commercially available rat pellet diet and normal drinking water ad libitum throughout the 13 weeks experimental period. After a one week acclimatization period, diabetes was induced in the animals in DBC and all CAF groups with an injection (i.p.) of the respective dosages of caffeine (mg/kg BW) 15 min before the injection (i.p.) of STZ (65 mg/kg BW) when normal saline was injected to the DBC group instead of caffeine. The NC group received normal saline and citrate buffer instead of caffeine and STZ, respectively. One week after the STZ injection, animals with non-fasting blood glucose > 300 mg/dl were considered as diabetic. Three weeks after the STZ injection, the animals in the CAF5 and CAF10 groups were eliminated from the study due to the severity of diabetes and the experiment was continued with the remainder groups for a 13 weeks period. At the end of the experimental period the rats were euthanized and blood and organ samples were collected for subsequent analysis. The data of daily food and fluid intake, weekly body weight and blood glucose, oral glucose tolerance test, serum insulin, fructosamine, lipid profile, organ specific and antioxidative enzymes, anti-diabetic drug response tests, and liver, heart, kidney and pancreas histopathology suggest that the CAF20 group can be a new and alternative non-obese non-genetic chemically-induced model for T2D and can be therefore used for both chronic and acute research studies as well as pharmacological screening of new anti-diabetic drugs. / Thesis (M.Sc.)-University of KwaZulu-Natal, Durban, 2013.

Thesis (M.Sc.)--York University, 2006. Graduate Programme in Kinesiology and Health Science. / Typescript. Includes bibliographical references (leaves 66-88). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR19754

Dissertation (Ph.D.)--The University of North Carolina at Greensboro, 2009. / Directed by Keith Erikson; submitted to the Dept. of Nutrition. Title from PDF t.p. (viewed Apr. 29, 2010). Includes bibliographical references (p. 154-191).

Please read the abstract in the section 00front of this document / Dissertation (MSc (Anatomy))--University of Pretoria, 2001. / Anatomy / unrestricted

published_or_final_version / Anaesthesiology / Master / Master of Philosophy