Made available in DSpace on 2016-03-15T19:26:32Z (GMT). No. of bitstreams: 1 Liliana Magon de Almeida.pdf: 885415 bytes, checksum: bf44fd103973bfe0307baa9ec3e599b9 (MD5) Previous issue date: 2007-08-13 / This study analyzes the knowledge management in Radiology Services. Through a theoretical revision inspired in the Resource Based View, the knowledge can be interpreted as a resource, with high potential to generate competitive advantage to its organization. In order to make possible that the competitive advantage generated by the organizational knowledge be sustained through time, this resource needs to be managed. The healthcare area, as it is intensive in knowledge, needs strong efforts to manage its knowledge, what justifies the choice for this area. Knowledge Management is, so, analyzed regarding two criteria: the conditions the organizations offers to develop knowledge internally, what is based on the Enablers Conditions described by Nonaka and Takeuchi (1997); and the Knowledge Management practices, based on Alavi and Leidner s (2001) process vision. Using descriptive research and data collected among radiologists, results were obtained to verify, first, the existence of the mentioned criteria in the Radiology Services, and second, if there is association between the two criteria. The results informed that Conditions Intention and Autonomy , clearly exist in the organizations, and Conditions Fluctuation and Creative Chaos , Redundancy and Variety of Requisites appeared only partially in their reality. The Practices Creation and Transference were clearly identified, but the Practices Retention and Application were only partially recognized. After establishing two clusters that represent a group with high level of knowledge management practices adoption and a group with low level of knowledge management practices adoption, the association between the groups and the Enabler Conditions was significant, refuting the hypothesis that this relation would be inexistent. / Pelo presente trabalho é analisada a gestão do conhecimento nos Serviços de Radiologia e Diagnóstico por Imagem. Com uma revisão teórica inspirada na Visão Baseada em Recursos, o conhecimento é indicado como um recurso com alto potencial de geração de vantagem competitiva para a organização. Para que a vantagem competitiva obtida por meio do recurso conhecimento seja efetivamente sustentável, a literatura aponta para a necessidade de sua gestão. A área de saúde, por ser intensiva em conhecimentos, precisa de cuidados específicos quanto à gestão destes recursos preciosos, o que justifica a escolha do ambiente de estudo. A Gestão do Conhecimento é analisada com base em dois critérios: as condições criadas pela organização para promover o conhecimento, embasado nas Condições Capacitadoras desenvolvidas por Nonaka e Takeuchi (1997), e as práticas de Gestão do Conhecimento, baseado na visão de processo de Alavi e Leidner (2001). Por meio de pesquisa descritiva, aplicada junto a médicos especialistas em radiologia, foram obtidos resultados para verificar, primeiro, a existência dos critérios mencionados nos Serviços de Radiologia e Diagnóstico por Imagem e, segundo, se havia associação entre os dois critérios. Os resultados indicaram a existência das Condições Capacitadoras Intenção e Autonomia , de forma clara, e as Condições Capacitadoras Flutuação e Caos Criativo , Redundância e Variedade de Requisitos , pelo menos parcialmente. As Práticas de GC Criação e Transferência foram claramente identificadas, enquanto as Práticas Estocagem e Retenção e Aplicação foram parcialmente identificas. Após o estabelecimento de clusters que agruparam as organizações em graus alto e baixo de Adoção de Práticas de GC, a associação entre as Condições Capacitadoras e os clusters mostrou-se significante, refutando a hipótese de que não existisse relação entre os dois critérios nesse ambiente de estudo.

A influência da atenção em processos de tomada de decisões é frequentemente avaliada através da tarefa denominada \"two-alternative choice\", em que os animais são treinados a emitir respostas baseadas na detecção e discriminação de dois estímulos discretos. Pela sua própria natureza, as possibilidades de se manipular a demanda atencional nessas tarefas é relativamente restrita. O desenho experimental básico adotado no presente conjunto de experimentos almejou possibilitar a variação das demandas atencionais durante o desempenho de uma tarefa que envolve discriminação auditiva, por meio da apresentação de sequências variáveis de \"beeps\" de mesma frequência (estímulos sonoros não informativos de 6 kHz) apresentados bilateralmente, seguidos de um estímulo informativo, um beep distinto de 3 ou 10 kHz, apresentado (1) bilateralmente, cuja frequência sinaliza a resposta a ser emitida (Experimento 1), ou (2) unilateralmente, cujo local de apresentação sinaliza a resposta a ser emitida (Experimento 2). No Experimento 1 observou-se uma redução dos tempos de reação para os estímulos alvo e uma redução da porcentagem de erros de comissão em função do aumento do número de estímulos não informativos, para ambos os estímulos informativos numa primeira fase e apenas para o de 10 kHz após a reversão da resposta inicialmente treinada. Curiosamente, os tempos de reação para o estímulo alvo de 10 kHz foram maiores em relação aos exibidos para o estímulo alvo de 3 kHz. Por outro lado, a redução da porcentagem de erros de comissão foi mais acentuada nas tentativas envolvendo o estímulo alvo de 10 kHz. No Experimento 2 houve aumento dos tempos de reação em função do aumento do número de estímulos não informativos apresentados. Os tempos de reação para o estímulo alvo de 10 kHz apresentado no lado esquerdo foram maiores em relação ao lado direito e também em relação ao estímulo alvo de 3 kHz apresentado no lado esquerdo ou direito. No mesmo sentido, houve menor percentagem de respostas corretas e maior percentagem de erros de comissão quando o estimulo alvo de 10 kHz foi apresentado no lado esquerdo. A porcentagem de respostas corretas assim como a redução dos tempos de reação são maiores no Experimento 2 em relação ao Experimento 1, sugerindo que nas presentes condições experimentais a identificação da fonte sonora é mais prontamente detectada do que a diferença de frequência dos estímulos alvo. Em conjunto os resultados obtidos mostram que o engajamento e manutenção de recursos atencionais longo do tempo variam em função da natureza periférica ou simbólica do estímulo alvo utilizado. A variação da frequência sonora dos estímulos alvo apresentados após uma sequência de estímulos não informativos também influencia o desempenho dos animais / The influence of attention in decision making processes is usually evaluated using two-alternative choice tasks in which the subjects react relying on detection and discrimination of two discrete stimuli. The possibilities of manipulating attentional demands in this kind of task is relatively restricted. The experimental design employed in the present experiments aimed at providing ways to manipulate the attentional demands during performance of an auditory task. This was achieved by presenting variable sequences of non-informative 6 kHz beeps, bilaterally, followed by one distinctive (either 3 or 10 kHz) informative beep presented either (1) bilaterally such that the frequency identifies the required response (Experiment 1) or (2) unilaterally such that the place of presentation identifies the required response (Experiment 2). In Experiment 1 data showed a decrease in both reaction times for target stimuli and percentage of comission errors as a function of the number of non-informative stimuli. These effects occurred early in training for both, 3 and 10 kHz target stimuli, and only for 10 kHz target stimulus after reversal of training. Interestingly, reaction times for 10 kHz target stimuli were longer relative to those seen for 3 kHz target stimuli. In contrast, reduction of the percentage of comission errors was stronger in trials using 10 kHz target stimuli. In Experiment 2 reaction times increased as a function of the increase in the number of non-informative stimuli. In addition, reaction times for 10 kHz target stimuli presented in the left side were longer as compared to both 10 kHz target stimuli presented in the right side and 3 kHz stimuli presented in both sides. Congruently, a smaller percentage of correct responses and a greater percentage of comission errors were seen when the 10 kHz target stimuli were presented in the left side. The percentage of correct responses and reaction times reduction were greater in the Experiment 2 as compared to Experiment 1, suggesting that in the present experimental conditions, identification of the place for stimulus presentation is prompter as compared to the difference in the frequency of the target stimuli. Together these results show that engagement and maintenance of attentional resources along time vary as a function of the peripheral and simbolic nature of the target stimuli. The frequency of target stimuli presented after a variable sequence of non-informative stimuli also interferes in performance of the subject

Le titane et ses alliages qui sont largement répandus dans l'industrie aéronautique, sont concernés par le fluage à température ambiante ce qui conduit à une réduction de la résistance et provoque le phénomène de rupture différée. Une partie des études montrent que ce comportement viscoplastique inhabituel à température ambiante est lié aux phénomènes d'interactions entre les dislocations et les atomes interstitiels comme l'hydrogène et l'oxygène, aussi appelés vieillissement statique et dynamique. Le but de cette étude à la fois expérimentale et numérique multi-échelle est de mieux comprendre les effets souvent antagonistes et en partie couplés de l'oxygène et de l'hydrogène en solution sur le comportement viscoplastique du titane non-allié de phase alpha. Dans un premier volet, un scénario du vieillissement statique et dynamique dans le titane non-allié de phase alpha est proposé. La présence du pic de traction est attribuée à la ségrégation des atomes interstitiels d'oxygène sur les dislocations coin de vecteur de Burgers <c+a>. Dans le cas du vieillissement dynamique les instabilités observées, typiques de l'effet Portevin-Le Chatelier, sont associées à l'étalement du cœur non planaire des dislocations vis de vecteur de Burgers <a>. Une loi de comportement prenant en compte les effets liés aux interactions entre dislocations et atomes en solution a été développée. Le modèle de Kubin-Estrin-McCormick qui permet de prendre en compte l'effet du vieillissement a été étendu au cas de la plasticité cristalline. Les simulations par éléments finis ont été réalisées sur des agrégats polycristallins avec différents nombres de grains. Ensuite, les essais de fissuration (ténacité et rupture différée) ont été réalisés sur les matériaux bruts, et chargés en hydrogène. Enfin, des simulations numériques de la rupture de ces éprouvettes ont été réalisées pour toutes les conditions expérimentales testées en utilisant le modèle de comportement mécanique macroscopique identifié. Un modèle de zone cohésive a été développé pour la simulation de la propagation des fissures. / Widely used for aircraft or rocket engine manufacturing titanium and its alloys are prone to the room-temperature creep that leads to the phenomenon of sustained load subcritical crack growth. One of the major cause of such unusual viscoplastic behavior of titanium is the phenomena of static and dynamic strain aging which represents an interaction between dislocations and interstitial atoms of oxygen and hydrogen. The aim of the present experimental and numerical multiscale study is to investigate the influence of the interstitial hydrogen and oxygen on the viscoplastic behavior and the resistance to sustained load cracking in commercially pure titanium of phase alpha.In a first step, a scenario of static and dynamic strain aging was proposed. The presence of the stress peak was attributed to the segregation of interstitial atoms of oxygen on the edge <c+a> dislocations. In case of dynamic strain aging, the observed instabilities, typical for the Portevin-Le Chatelier effect, were associated with the non-planar core of screw <a>-type dislocations. The crystal plasticity was introduced into the phenomenological model in order to capture the strain aging phenomena and the anisotropy of the mechanical properties. The modeling approach for strain aging suggested by Kubin-Estrin-McCormick is based on the internal variable called the aging time which corresponds to the waiting time of a dislocation in a pinned state. Finite element simulations were then performed on the polycrystalline aggregates for different number of grains. At the next step, fracture toughness and sustained load cracking tests were performed on the material with different levels of hydrogen. Finally, numerical simulations of toughness and sustained load cracking tests using the identified viscoplastic model were carried out for all experimental conditions. A cohesive zone model was then introduced ahead of the crack tip to simulate crack propagation.

Water droplets tend to bead up on rough or textured hydrophobic surfaces by trapping air on the crevices underneath resulting in “Cassie” state of wetting. When a textured hydrophobic surface is immersed in water, the resulting underwater “Cassie” state can lead to significant drag reduction. The entrapped air pockets act as shear free regions and the composite interface consisting of alternate no slip and no shear regions thus formed can deliver substantial drag reduction during flow. The magnitude of drag reduction depends not only on the fractional coverage of air on the surface, but also on the size of the air pockets, with larger sized air pockets facilitating larger drag reduction. It is a common observance that Lotus leaf when kept immersed in water for a few minutes loses its water repellency due to the loss of entrapped air on the surface. Underwater Cassie state on textured hydrophobic surfaces is also not sustainable because of the depletion of air pockets caused by the diffusion of trapped air into water. This causes the drag reduction to diminish with time. Rate of diffusion of air across the water–air interface depends on the concentration gradient of air across the interface. Under flow conditions, removal of entrapped air is further enhanced by convection, leading to more rapid shrinkage of the air pockets. In order to sustain the Cassie state, it is thus necessary to continuously supply air to these air pockets. In this work, we explore the possibility of supplying air to the cavities on the textured surface inside a microchannel by controlling the solubility of air in water close to the surface. The solubility is varied by i) Controlling the absolute pressure inside the channel and ii) Localized heating of the surface To trap uniform air pockets, a textured surface containing a regular array of blind holes is used. The textured surface is generated by photo etching of brass and is rendered hydrophobic through a self-assembled monolayer. The sustainability of the underwater Cassie state of wetting on the surface is studied at various flow conditions. The air trapped on the textured surface is visualized using total internal reflection based technique, with the pressure drop (or drag) being simultaneously measured. Water which is initially saturated with air at atmospheric conditions, when subjected to sub-atmospheric pressures within the channel becomes supersaturated causing the air bubbles to grow in size. Further growth causes the bubbles to merge and eventually detach from the surface. The growth and subsequent merging of the air bubbles leads to a substantial increase in the pressure drop because as the air pockets grow in size, they project into the flow and start obstructing the flow. On the other hand, a pressure above the atmospheric pressure within the channel makes the water undersaturated with air, leading to gradual shrinkage and eventual disappearance of air bubbles. In this case, the air bubbles do cause reduction in the pressure drop with the minimum pressure drop (or maximum drag reduction) occurring when the bubbles are flush with the surface. The rate of growth or decay of air bubbles is found to be significantly dependent on the absolute pressure in the channel. Hence by carefully controlling the absolute pressure, the Cassie state of wetting can be sustained for extended periods of time. A drag reduction of up to 15% was achieved and sustained for a period of over 5 hours. Temperature of water also influences the solubility of air in water with higher temperatures resulting in reduced solubility. Thus locally heating the textured hydrophobic surface causes the air bubbles to grow, with the rate of growth being dependent on the heat input. The effect of trapped air bubbles on thermal transport is also determined by measuring the heat transfer rate through the surface in the presence and absence of trapped air bubbles. Even though the trapped air bubbles do cause a reduction in the heat transfer coefficient by about 10%, a large pressure drop reduction of up to 15% obtained during the experiments helps in circumventing this disadvantage. Hence for the same pressure drop across the channel, the textured hydrophobic surface helps to augment the heat transfer rate. The experiments show that, by varying the solubility of air in water either by controlling the pressure or by local heating, underwater Cassie state of wetting can be sustained on textured hydrophobic surfaces, thus delivering up to 15% drag reduction in both cases for extended periods of time. The results obtained hold important implications towards achieving sustained drag reduction in microfluidic applications.

L’objectif de ces travaux de thèse était d’avancer dans la connaissance des effets du vieillissement normal sur les capacités d’attention soutenue et les mécanismes de contrôle attentionnel qui les sous-tendent. A cette fin, nous avons combiné l’utilisation de mesures comportementales, subjectives, et électrophysiologiques (potentiels évoqués). Les résultats comportementaux mettent en évidence des effets différenciés de l’âge sur les capacités d’attention soutenue en fonction de l’approche utilisée : détérioration dans les tâches de détection, et préservation dans les tâches d’inhibition. Les données électrophysiologiques mettent en évidence plusieurs spécificités des seniors dans l’engagement des mécanismes de contrôle attentionnel en situation d’attention soutenue : une activation globalement plus importante de ces mécanismes, une activation maintenue ou augmentée de ces mécanismes au fil de la tâche, et une topographie plus frontale des régions qui les sous-tendent. / The purpose of this project was to gain more knowledge about the effects of normal aging on sustained attention ability and attentional control mechanisms underlying this ability. To that end, we combined the use of behavioral, subjective and electrophysiological (event-related potentials) measures. Behavioral results evidenced differential effects of age on sustained attention ability according to the approach used: deterioration in detection tasks, and preservation in inhibition tasks. Electrophysiological data evidenced several special features of seniors regarding the recruitment of attentional control mechanisms in a situation of sustained attention: overall greater activation of these mechanisms, stable or increased activation of these mechanisms over the course of the task, and a more frontal topography of the regions underlying these mechanisms.

L’objectif de ce travail de thèse a été d’avancer dans les connaissances des mécanismes de contrôle cognitif sous-tendant les détériorations et fluctuations d’attention soutenue chez les patients souffrant de schizophrénie et les sujets sains. Dans ce but, nous avons combiné mesures comportementales, électrophysiologiques et subjectives. Nos résultats montrent une préservation des capacités d’attention soutenue chez les patients ainsi qu’une origine distincte des variations d’attention soutenue chez les patients. Les détériorations sont sous-tendues par une diminution du mode de contrôle réactif chez les patients et du mode proactif chez les témoins. De plus, différents précurseurs des lapses attentionnels ont été mis en évidence chez les patients selon l’état attentionnel. Les variations d’attention soutenue sont principalement liées à une diminution des ressources attentionnelles chez les patients, alors que chez les témoins, en fonction de l’état attentionnel, elles pourraient également être liées à un désengagement, une défaillance du contrôle cognitif. / The purpose of this project was to gain more knowledge about cognitive control mechanisms underlying deteriorations and fluctuation of sustained attention in schizophrenia and healthy participants. To that end, we combined the use of behavioral, electrophysiological (event-related potentials and functional connectivity) and subjective measures. Our results revealed spared sustained attention in schizophrenia and a distinct patterns of sustained attention changes in schizophrenia. Deteriorations are underlined by a decrease of reactive mode of cognitive control in patients and by a decrease of proactive mode in controls. Our results also highlighted slightly distinct patterns of precursors of lapses in sustained attention in schizophrenia according to the attentional state. Sustained attention changes are associated with resource depletion in patients, whereas in healthy participants, according to attentional state, they could also be caused by disengagement of cognitive control.

Att vara lönsam är en förutsättning för företags långsiktiga överlevnad. Samtidigt blir det generellt sett allt hårdare konkurrens och antalet konkurrenter ökar ständigt. Företag behöver således hitta sätt för att kunna fortsätta vara konkurrenskraftiga på marknaden. Enligt resursbaserad teori kan företag inneha eller skapa resurser inom sin verksamhet som kan leda till varaktiga konkurrensfördelar, och som följaktligen är viktiga att identifiera och utnyttja på bästa sätt. En tillfällig konkurrensfördel anses vara värdefull, ovanlig samt icke utbytbar. För att resursen ska kunna anses vara varaktig ska den inte heller gå att imitera av konkurrenter. I denna rapport ligger fokus på hur företag inom dagligvaruhandeln försöker skapa varaktiga konkurrensfördelar genom arbetet med miljövänliga förpackningar. Miljövänliga förpackningar utgör en betydande del av branschens miljöpåverkan då dessa kännetecknas av hög omsättning och snabb förbrukning. Idag utgör egna varumärken allt större del av omsättningen bland företagen. Dessa varumärken har företagen självklart en betydande möjlighet att påverka, bland annat produktens egenskaper och inte minst dess förpackning. Denna studie bygger på intervjuer med respondenter från tre företag inom dagligvaruhandeln med varierande marknadsandelar. Studien visar att företagen arbetar med miljövänlig förpackningsutveckling på många sätt. Rapporten redogör för hur företagen arbetar för att effektivisera förpackningskedjan, utveckla förpackningar som minskar matsvinn samt hur samarbeten mellan förpackningskedjans användare ser ut och dess betydelse. Det diskuteras även huruvida åtgärderna syftar till att utveckla varaktiga konkurrensfördelar eller ej. Det beskrivs även hur företagen kommunicerar sitt arbete med miljövänliga förpackningar samt hur de strävar efter att utveckla förpackningsinnovationer.

Wall transpiration, in the form of wall-normal suction or blowing through a permeable wall, is a relatively simple and effective technique to control the behaviour of a boundary layer. For its potential applications for laminar-turbulent transition and separation delay (suction) or for turbulent drag reduction and thermal protection (blowing), wall transpiration has over the past decades been the topic of a significant amount of studies. However, as far as the turbulent regime is concerned, fundamental understanding of the phenomena occurring in the boundary layer in presence of wall transpiration is limited and considerable disagreements persist even on the description of basic quantities, such as the mean streamwise velocity, for the rather simplified case of flat-plate boundary-layer flows without pressure gradients. In order to provide new experimental data on suction and blowing boundary layers, an experimental apparatus was designed and brought into operation. The perforated region spans the whole 1.2 m of the test-section width and with its streamwise extent of 6.5 m is significantly longer than previous studies, allowing for a better investigation of the spatial development of the boundary layer. The quality of the experimental setup and measurement procedures was verified with extensive testing, including benchmarking against previous results on a canonical zero-pressure-gradient turbulent boundary layer (ZPG TBL) and on a laminar asymptotic suction boundary layer. The present experimental results on ZPG turbulent suction boundary layers show that it is possible to experimentally realize a turbulent asymptotic suction boundary layer (TASBL) where the boundary layer mean-velocity profile becomes independent of the streamwise location, so that the suction rate constitutes the only control parameter. TASBLs show a mean-velocity profile with a large logarithmic region and without the existence of a clear wake region. If outer scaling is adopted, using the free-stream velocity and the boundary layer thickness (δ99) as characteristic velocity and length scale respectively, the logarithmic region is described by a slope Ao=0.064 and an intercept Bo=0.994, independently from the suction rate (Γ). Relaminarization of an initially turbulent boundary layer is observed for Γ&gt;3.70×10−3. Wall suction is responsible for a strong damping of the velocity fluctuations, with a decrease of the near-wall peak of the velocity-variance profile ranging from 50% to 65% when compared to a canonical ZPG TBL at comparable Reτ. This decrease in the turbulent activity appears to be explained by an increased stability of the near-wall streaks. Measurements on ZPG blowing boundary layers were conducted for blowing rates ranging between 0.1% and 0.37% of the free-stream velocity and cover the range of momentum thickness Reynolds number 10000&lt;Reθ&lt;36000. Wall-normal blowing strongly modifies the shape of the boundary-layer mean-velocity profile. As the blowing rate is increased, the clear logarithmic region characterizing the canonical ZPG TBLs gradually disappears. A good overlap among the mean velocity-defect profiles of the canonical ZPG TBLs and of the blowing boundary layers for all the Re number and blowing rates considered is obtained when normalization with the Zagarola-Smits velocity scale is adopted. Wall blowing enhances the intensity of the velocity fluctuations, especially in the outer region. At sufficiently high blowing rates and Reynolds number, the outer peak in the streamwise-velocity fluctuations surpasses in magnitude the near-wall peak, which eventually disappears. / Genom att använda sig av genomströmmande ytor, med sugning eller blåsning, kan man relativt enkelt och effektivt påverka ett gränsskikts tillstånd. Genom sin potential att påverka olika strömningsfysikaliska fenomen så som att senarelägga både avlösning och omslaget från laminär till turbulent strömning (genom sugning) eller som att exempelvis minska luftmotståndet i turbulenta gränsskikt och ge kyleffekt (genom blåsning), så har ett otaligt antal studier genomförts på området de senaste decennierna. Trots detta så är den grundläggande förståelsen bristfällig för de strömningsfenomen som inträffar i turbulenta gränsskikt över genomströmmande ytor. Det råder stora meningsskiljaktigheter om de mest elementära strömningskvantiteterna, såsom medelhastigheten, när sugning och blåsning tillämpas även i det mest förenklade gränsskiktsfallet nämligen det som utvecklar sig över en plan platta utan tryckgradient. För att ta fram nya experimentella data på gränsskikt med sugning och blåsning genom ytan så har vi designat en ny experimentell uppställning samt tagit den i bruk.Den genomströmmande ytan spänner över hela bredden av vindtunnelns mätsträcka (1.2 m) och är 6.5 m lång i strömningsriktningen och är därmed betydligt längre än vad som använts i tidigare studier. Detta gör det möjligt att bättre utforska gränsskiktet som utvecklas över ytan i strömningsriktningen. Kvaliteten på den experimentella uppställningen och valda mätprocedurerna har verifierats genom omfattande tester, som även inkluderar benchmarking mot tidigare resultat på turbulenta gränsskikt utan tryckgradient eller blåsning/sugning och på laminära asymptotiska sugningsgränsskikt. De experimentella resultaten på turbulenta gränsskikt med sugning bekräftar för första gången att det är möjligt att experimentellt sätta upp ett turbulent asymptotiskt sugningsgränsskikt där gränsskiktets medelhastighetsprofil blir oberoende av strömningsriktningen och där sugningshastigheten utgör den enda kontrollparametern. Det turbulenta asymptotiska sugningsgränsskiktet visar sig ha en medelhastighetsprofil normalt mot ytan med en lång logaritmisk region och utan förekomsten av en yttre vakregion. Om man använder yttre skalning av medelhastigheten, med friströmshastigheten och gränsskiktstjockleken som karaktäristisk hastighet respektive längdskala, så kan det logaritmiska området beskrivas med en lutning på Ao=0.064 och ett korsande värde med y-axeln på Bo=0.994, som är oberoende av sugningshastigheten. Om sugningshasigheten normaliserad med friströmshastigheten överskrider värdet 3.70x10^-3 så återgår det ursprungligen turbulenta gränsskiktet till att vara laminärt. Sugningen genom väggen dämpar hastighetsfluktuationerna i gränsskiktet med upp till 50-60% vid direkt jämförelse av det inre toppvärdet i ett turbulent gränsskikt utan sugning och vid jämförbart Reynolds tal. Denna minskning av turbulent aktivitet verkar härstamma från en ökad stabilitet av hastighetsstråken närmast ytan. Mätningar på turbulenta gränsskikt med blåsning har genomförts för blåsningshastigheter mellan 0.1 och 0.37% av friströmshastigheten och täcker Reynoldstalområdet (10-36)x10^3, med Reynolds tal baserat på rörelsemängds-tjockleken. Vid blåsning genom ytan får man en stark modifiering av formen på hastighetesfördelningen genom gränsskiktet. När blåsningshastigheten ökar så kommer till slut den logaritmiska regionen av medelhastigheten, karaktäristisk för turbulent gränsskikt utan blåsning, att gradvis försvinna. God överens-stämmelse av medelhastighetsprofiler mellan turbulenta gränsskikt med och utan blåsning erhålls för alla Reynoldstal och blåsningshastigheter när profilerna normaliseras med Zagarola-Smits hastighetsskala. Blåsning vid väggen ökar intensiteten av hastighetsfluktuationerna, speciellt i den yttre regionen av gränsskiktet. Vid riktigt höga blåsningshastigheter och Reynoldstal så kommer den yttre toppen av hastighetsfluktuationer i gränsskiktet att överskrida den inre toppen, som i sig gradvis försvinner. / <p>QC 20171101</p>

Ce travail a été mené afin de développer des systèmes polymériques particulaires chargés en facteur de croissance (TGF-β1) en vue d’une application à l’ingénierie tissulaire du cartilage. Tout d’abord, des nanoparticules d’acide poly(lactique-co-glycolique) (PLGA) ont été générées par un procédé basé sur la séparation de phase. De plus, des microparticules de PLGA ont été formées à l’aide d’un procédé d’émulsification/extraction du solvant en milieu CO2 pressurisé. L’un des avantages de ces procédés de formulation est l’utilisation de solvants injectables, non toxiques et non volatils. Les systèmes polymériques préparés ont été caractérisés et des particules sphériques à libération contrôlée ont été obtenues avec un rendement d’encapsulation satisfaisant tout en préservant l’activité biologique du facteur de croissance. Les particules chargées en TGF-β1 ont ensuite été incorporées dans un hydrogel injectable à base d’un dérivé cellulosique silanisé (Si-HPMC) contenant des cellules souches. Le biomatériau obtenu a été caractérisé en termes de morphologie, de propriétés rhéologiques et pour sa capacité à libérer le facteur de croissance. La libération contrôlée et localisée du TGF-β1 pourrait induire la survie, la prolifération ainsi que la différenciation chondrocytaire des cellules souches associées ce qui contribuerait à la régénération du cartilage. En conclusion, le biomatériau hybride élaboré au cours de ce travail possède un potentiel prometteur pour l’ingénierie tissulaire du cartilage. / The aim of this work is to develop polymeric particulate systems loaded with transforming growth factor (TGF-β1) for cartilage tissue engineering application. First, nanoparticles of PLGA (poly(lactic-co-glycolic) acid) were generated using a phase separation method while PLGA microparticles were prepared by an emulsification/extraction process in CO2 medium. Interestingly, non-toxic, non-volatile injectable solvents were used in the formulation processes. The prepared polymeric systems were characterized; spherical particles with sustained release were obtained and satisfactory encapsulation efficiency was achieved with preservation of the growth factor bioactivity. TGF-β1-loaded particles were then incorporated within injectable silanized cellulose-based hydrogel (Si-HPMC) containing stem cells. The obtained biomaterial was characterized in terms of morphology, rheological properties and release study. The local and sustained release of TGF-β1 could induce survival, proliferation and differentiation of stem cells into chondrocytes which may promote cartilage regeneration. To conclude, the elaborated hybrid biomaterial has a promising potential for cartilage tissue engineering.

Ce mémoire porte sur l'étude et l’optimisation du fonctionnement des extensomètres à corde vibrante pour la surveillance des constructions stratégiques. Ce travail se décompose en trois étapes.Premièrement, le fonctionnement du capteur en mode amorti et en mode entretenu est décrit. Un dispositif électronique de lecture à base de microcontrôleur est réalisé pour valider les développements. Deuxième, le comportement du capteur est étudié en établissant des modèles représentant les couplages magnéto-mécaniques entre la corde vibrante, la bobine d'excitation et la bobine de mesure. Les influences du mode d'excitation et des paramètres parasites sur la réponse du capteur sont analysées. Enfin, l'effet de la foudre est simulé en utilisant un simulateur de décharge électrostatique. La réponse du capteur est mesurée avant, pendant et après la décharge. Les résultats de ce travail peuvent se résumer en quatre points essentiels. Premièrement, le mode entretenu est préférable au mode amorti. Deuxièmement, la position d'excitation optimale est au centre de la corde. De plus, une excitation continue ou une excitation pulsée d'un grand nombre de cycles est préférable à une excitation pulsée d'un petit nombre de cycles. Troisièmement, la fréquence de résonance mesurée en mode entretenu diffère de celle mesurée en mode amorti à cause de deux paramètres : la force magnétique moyenne et le couplage mutuel entre les bobines. Quatrièmement, sous l'action des décharges, le champ magnétique résiduel est modifié, conduisant ainsi à une modification de la fréquence de résonance mesurée par le capteur. / This thesis focuses on the study and the optimization of the operation of vibrating wire sensors for strategic construction monitoring. This work is divided into three stages.Firstly, the sensor operation in damped mode and in sustained mode is described. To validate the developments, an electronic microcontroller-based reading device is realized. Secondly, the sensor behavior is investigated by establishing models representing the magneto-mechanical coupling between the vibrating wire, the excitation coil and the measurement coil. The influences of excitation mode and spurious parameters on the sensor response are analyzed. Finally, the effect of lightning is simulated using electrostatic discharge simulator. The sensor response is measured before, during and after discharge.The results of this work can be summarized in four main points. Firstly, the sustained mode is preferable to the damped mode. Secondly, the optimal excitation position is at the center of the wire. Furthermore, a continuous excitation or a pulsed excitation of a large number of cycles is preferable to a pulsed excitation of a small number of cycles. Thirdly, the resonant frequency measured in sustained mode differs from that measured in damped mode due to two parameters: average magnetic force and mutual coupling between coils. Fourthly, under the action of discharges, the remaining magnetic field is modified, thus leading to a variation in the resonant frequency measured by the sensor.