OmniMerge performs a systematic search to enumerate all conformations of a molecule (at a given level of torsion-angle resolution) that satisfy a set of local geometric constraints. Constraints would typically come from NMR experiments, but applications such as docking or homology modeling could also give rise to similar constraints. The molecule to be searched is partitioned into small subchains so that the set of possible conformations for the whole molecule may be constructed by merging the feasible conformations for the subchain parts. However, instead of using a binary tree for straightforward divide-and-conquer, OmniMerge defines a sub-problem for every possible subchain of the molecule. Searching every subchain provides a counter-intuitive advantage: with every possible subdivision available for merging, one may choose the most favorable merge for each subchain, particularly for the bottleneck chain(s). Improving the bottleneck step may therefore cause the whole search to be completed more quickly. Finally, to discard infeasible conformations more rapidly, OmniMerge filters the solution set of each subchain based on compatibility with the solutions sets of all overlapping subchains. These two innovations—choosing the most favorable merges and enforcing consistency between overlapping subchains—yield significant improvements in run time. By determining the extent of structural variability permitted by a set of constraints, OmniMerge offers the potential to aid error analysis and improve confidence for NMR results on peptides and moderate-sized molecules. / Singapore-MIT Alliance (SMA)

The theoretical part describes the field of personnel policy, focusing on the issue of finding employees. The Master´s thesis is focused on the work headhunting companies in comparison with the work of employment agencies. The aim of my work is verify possibility to determine the situations in which it is more efficient to use the method of direct systematic search and when the classical method of recruitment. In my work I analyze not only the management of human resources but also the functioning of the personnel departments of companies with reference to personal marketing. The Master´s thesis is also supplemented with practical knowledge and the final section describe the outcome of the survey

The theoretical part of this thesis describes internal and external ways that can be of use while appointing employees. The thesis is focused on using direct systematic search (Executive Search) in the environment of consulting company CSP Partners Ltd. and its aim is to show the specific features of this method usually used to appoint specialists or managers. Commercial and executive processes of the company are depicted within the text. Using analytical tools this thesis examines the whole HR consulting industry in the context of Czech labor market. Historical development and recent trends are included, ethical dimension as well as motivation of candidates approached using this method are described as well. Many practical notes are involved and the final part describes one of CSP Partners' Ltd. projects in detail.

A variety of new treatment options for skin cancer patients drives the need for information and education, which is increasingly met by videos and websites [1, 2]. However, distinguishing between high- and low-quality content becomes more difficult as the number of videos increases. Recently, videos addressing patients with melanoma or basal cell carcinoma (BCC) were found to be of predominantly mediocre quality and poor reliability [3, 4]. Until now, no evaluation of videos on cutaneous squamous cell carcinoma (cSCC) has been performed. Furthermore, no patient guideline currently exists for this entity [5–7]. Therefore, we aimed to systematically identify and evaluate videos on cSCC, the worldwide second most common type of skin cancer after BCC [8]. Our results will contribute to shared decision-making and help physicians and patients to select high-quality videos.