Made available in DSpace on 2015-07-22T20:50:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-07-29 / Objetivos: Avaliar a concordância no diagnóstico das lesões cutâneas pigmentadas por meio do exame dermatoscópico presencial e a distância. Analisar a concordância diagnóstica da teledermatoscopia e do exame dermatoscópico presencial em relação ao resultado anatomopatológico. Verificar a acurácia, a sensibilidade e a especificidade da teledermatoscopia na detecção das lesões pigmentadas malignas. Métodos: Sessenta e quatro lesões cutâneas pigmentadas foram submetidas a exame clínico e dermatoscópico realizado presencialmente por dois examinadores com experiência em dermatoscopia, durante o ano de 2005, no ambulatório de dermatoscopia do Departamento de Dermatologia da Universidade Federal de São Paulo (UNIFESP). Após dois anos, imagens digitais clínicas e dermatoscópicas destes casos foram reexaminadas pelos mesmos especialistas por meio da transmissão de imagens e de dados clínicos via web. Resultados: Observou-se boa concordância diagnóstica entre o exame presencial e a teledermatoscopia com valor de Kappa de 0,698 (IC a 95% - [0,575; 0,821]). Verificou-se também boa concordância entre o exame presencial e a teledermatoscopia com o resultado anatomopatológico (padrão ouro) com valores de Kappa de 0,728 (IC a 95% - [0,608; 0,848]) e 0,656 (IC a 95% - [0,526; 0,785]), respectivamente. Constatou-se 84% de acurácia, 93% de sensibilidade e 78% de especificidade na detecção das lesões pigmentadas malignas no exame dermatoscópico a distância. Dois casos falsos negativos foram observados pela teledermatoscopia. Não houve diferença estatisticamente significante entre a sensibilidade, a especificidade e a acurácia das duas modalidades diagnósticas. Conclusões: O exame dermatoscópico a distância pela transmissão de imagens digitais e de dados clínicos proporcionou acurácia diagnóstica, sensibilidade e especificidade comparáveis ao exame convencional. A teledermatoscopia mostrou ser método eficaz e confiável na detecção das lesões malignas constituindo ferramenta importante na triagem das lesões pigmentadas. A boa concordância diagnóstica entre a avaliação via web e o exame presencial destaca a aplicabilidade da teledermatoscopia como instrumento de assistência especializada em regiões de difícil acesso ou carentes no setor de saúde. / Objectives: To evaluate agreement in diagnosis of pigmented skin lesions through presential or remote dermoscopic examination. To analyze diagnosis agreement of teledermoscopy and presential dermoscopic examination regarding pathological findings. To verify accuracy, sensibility and specificity of teledermoscopy in detection of malignant pigmented lesions. Methods: A total of 64 pigmented skin lesions were submitted to clinical and dermoscopic examinations performed presentially by two examiners experienced in dermoscopy, at the Dermoscopy Outpatient’s Clinic, Department of Dermatology, Universidade Federal de São Paulo (UNIFESP), in 2005. Two years later, the digital clinical and dermoscopic images of these cases were re-examined by the same specialists through transmission of images and clinical data via web. Agreement between presential diagnosis and telediagnosis was assessed by the Kappa (κ) statistic calculation and its respective 95% confidence interval (95% CI). Through this calculation, the agreement between presential presumptive diagnoses and telediagnoses with pathological findings was analyzed. Sensitivity, specificity and accuracy of two diagnostic modalities were obtained using the pathological examination as the gold standard. The respective 95% confidence interval (95% CI) was calculated for each diagnostic measurement. Results: Good diagnostic agreement was observed between presential examination and teledermoscopy, with a Kappa value of 0.698 (95% CI - [0.575; 0.821]). Good agreement was also found between conventional examination and teledermoscopy, and the pathological findings (gold standard) had Kappa values of 0.728 (95% CI - [0.608; 0.848]) and 0.656 (95% CI - [0.526; 0.785]), respectively. Accuracy of 84%, sensitivity of 93% and specificity of 78% were observed in detecting malignant pigmented lesions by remote dermoscopic examination. Two false negative cases were observed through teledermoscopy. There was no statistically significant difference in sensitivity, specificity and accuracy of both diagnostic methods. Conclusions: Remote dermoscopic examination by means of digital image transmission and of clinical data provided diagnostic accuracy, sensitivity and specificity comparable to conventional examination. Teledermoscopy proved to be an efficient and reliable method to detect malignant lesions, representing an important tool to screen pigmented lesions. The good diagnostic agreement between assessment via web and conventional examination highlights the applicability of teledermoscopy as a specialized assistance tool in regions that are difficult to reach or lack health resources. / TEDE / BV UNIFESP: Teses e dissertações

Since the 1800's, technological advances have extended the foundation on which telemedicine could build. With its evolution, telemedicine has proven to be a means of offering effective health care interventions, from a multitude of disciplines. Teledermatology, a specialty application of telemedicine, offers great potential in improving the standard of dermatologic care by bridging the gap between the expert opinion of dermatologists and those without access to basic dermatologic care, particularly in developing nations, where skin disease continues to be a major public health problem. In Honduras, the setting for this study, and other developing nations, technology to support telemedicine is available. Dermatologic disease is among the most common disease presentations in the developing world, which left untreated due to a lack of access to adequate medical care, can progress causing increased morbidity or even death. A potential but untested solution is teledermatology. Teledermatology offers great potential in improving the standard of dermatologic care by bridging the gap between the expert opinion of dermatologists and those without access to basic dermatologic care. The purpose of this study was to evaluate the prevalence and types of dermatologic conditions and the feasibility of a store-and-forward teledermatology system in an underserved area of Honduras, so as to potentially provide more timely diagnosis and treatment, implementation of preventative measures, and offer long term solutions.so as The justification and significance of this study was the potential of store-and-forward teledermatology to improve the standard of dermatologic care by improving access of populations in underserved areas to dermatology specialists through affordable technology. The methodology of this study was primarily case study descriptive. This study was conducted at a public primary care clinic (JMA Clinic) and satellite sites in underserved areas of Francisco Morazán, Honduras. During a four week period in Spring 2011, patients with dermatologic conditions were examined and photos taken of condition. The patient information was sent to 3 U.S. board certified dermatologists, who provided diagnosis and treatment within 24 hours, which allowed the clinic physician sufficient time to review recommendations before patient follow-up. Patients would receive follow-up within 48 hours of initial visit. Diagnostic agreement, image quality, and user satisfaction were evaluated. IRB forms were submitted and clearance given. The data was analyzed with SPSS using descriptive statistics. The primary findings were the types of dermatologic conditions, interobserver agreement, image quality, and patient and physician satisfaction. The findings of this study substantiate the need for dermatologic care, as approximately 1 out of every 5 patients of the JMA Clinic presented with a dermatologic condition. The majority of these patients were children or women in their late 20s and early 30s; many of whom had their condition for more than a year and most had not received prior therapy. The types of dermatologic conditions observed were typical of that seen at a dermatology clinic in the U.S., yet inclusive of tropical and regional differences. Dermatitis, infectious and pigmentary conditions were the most common presentations. The interobserver diagnostic agreement achieved was 78%, and improved when considering differential diagnoses. Image quality received high ratings. Patients and physicians recorded a high level of overall satisfaction. Physicians indicated improved knowledge of teledermatology. Because of the unique environment and circumstances, the results are limited to the setting in which the study occurs. This project was a pilot study limited to 4 weeks of data collection and will be limited in significance by its duration and small sample size with respect to the conclusions that can be drawn about the prevalence and types of dermatologic conditions. This study illustrates that teledermatology is a viable means of providing dermatologic care to those in an underserved area of Honduras, where a lack of or limited access to general healthcare or specialty dermatologic care exists. The data offers insights to draw conclusions and recommendations on the potential for similar models to be implemented in underserved areas throughout Honduras and other similar regions. / Ph. D.

La télédermatologie présente plusieurs avantages par rapport aux consultations traditionnelles en cabinet avec un dermatologue. Elle est particulièrement utile pour faciliter l'accès aux soins dermatologiques pour les patients ayant des problèmes de mobilité ou habitant loin des secteurs géographiques médicalisés. Un schéma de mosaïquage automatique d’images dédié à la création des panoramas étendus des vidéo-séquences de peau est proposé pour surmonter les limitations posées par le champ de vue réduit des images stationnaires acquises par les dispositifs actuellement utilisés. Les vidéo-séquences utilisées à cet effet sont acquises en utilisant un dispositif spécialement conçu pour un rendu colorimétrique contrôlé de la surface de la peau. Après une étude des diverses méthodes de recalage d'images existantes, une approche optimale est proposée, avec un certain compromis entre la précision de recalage et le temps de calcul, pour la superposition des parties communes des images cutanées. En outre, une approche pour affiner la correspondance initiale des points caractéristiques extraits est présentée. L'étude présentée porte principalement sur la construction cohérente d’une mosaïque dans son ensemble. Pour atteindre cet objectif, un schéma de mosaïque capable de générer des panoramas cohérents à partir de vidéo-séquences longues est présenté. Ce schéma estime dynamiquement la topologie de la trajectoire des images dans le plan de mosaïquage. Cela permet de placer les images sur le plan panoramique avec un nombre réduit d'images sur le chemin suivi pour atteindre une image donnée à partir d'une image de référence, ce qui réduit non seulement l'accumulation des erreurs, mais permet également d'éviter les interruptions dans le mosaïquage en excluant les paires d'images dont le recalage ne serait pas réussi. L'approche proposée offre une robustesse vis-à-vis des recalages échoués en trouvant des trajets alternatifs. En outre, un mode d'ajustement global pour améliorer davantage la cohérence de la mosaïque est présenté / Teledermatology offers several advantages in comparison to the traditional in-place consultations with a dermatologist. It is particularly useful for easing the access to the dermatological care for patients with mobility or travel constraints. A dedicated mosaicing scheme for creating extended panoramas of skin video sequences is proposed to surmount the limitations posed by the small field of view of stationary images acquired by currently used devices. The video sequences used for this purpose are acquired using a specially designed device for a colorimetrically correct rendering of the skin surface. After a study of various image registration approaches, an approach optimally suited to skin image registration with some compromise between registration accuracy and computation time is selected. In addition, an approach for refining the initially detected key-point correspondence is presented. Central focus of this study is on the overall coherent construction of the mosaic. To achieve this objective, a mosaicing scheme capable of generating coherent panoramas from long video sequences is presented. This scheme dynamically estimates the topology of the image trajectory in the panoramic plane to mosaic the images by reducing the number of images over the path used for reaching a given image from a reference image in order to place it on the panoramic plane. A small number of images reduces the accumulated errors, thus improving the visual coherency of the overall mosaic. Besides, the proposed approach offers robustness against failed registrations, which would interrupt the mosaicing process in the absence of the alternative paths. Moreover, a global adjustment scheme for further improving the coherency of the mosaic is presented

La conception d’un produit ou d’un service en Santé est un processus complexe et risqué. Il doit intégrer dans les phases précoces de conception les normes, les contraintes réglementaires, les données de surveillance et d’évaluation de la sécurité jusqu’à l’autorisation de mise sur le marché pour les dispositifs médicaux, mais également les préférences des utilisateurs experts : professionnels de santé ou non-experts : patients. Dans le marché compétitif des nouveaux produits ou services en Santé, l’enjeu pour les ingénieurs est de faire coïncider les besoins des utilisateurs à leur contexte et usages tout en intégrant toutes les parties prenantes du système de soin. Innovation médicale, technologique et organisationnelle, la télémédecine (TM) est l’utilisation des nouvelles technologies pour délivrer des actes médicaux. L’objectif de cette thèse est la mise au point d’une méthodologie centrée sur les utilisateurs et leurs usages pour concevoir, développer, intégrer et valider une application dermatologique de la TM : la télédermatologie. L’opportunité de validation de cette méthodologie pour intégrer et déployer un service innovant dans un service de dermatologie y est également discutée. / Designing product or services for healthcare system is highly complex, costly and risky. It combines constraints such as being a multi decisional and multilevel system with specific financial model linked to the state the healthcare system organization belongs to. In the highly marketing-time sensitive context of innovative products or services, there is challenge for designers to be able to match the new design to the users’ needs, answering to their context or usages while integrating all system stakeholder components. Telemedicine (TM) is the use of ITtechnologies to provide medical care or medical advice. It is considered a care delivery transformation combining medical, technological and organizational innovation. Using the example of Teledermatology a dermatological application of TM, this PhD develops a methodology based upon users contexts and usages to design integrate and provide an assessment model to decision makers. The opportunity to implement and integrate the service in French department of dermatology is discussed.