It has been proven that platinum and ruthenium complexes are active in anti- cancer treatment. Nowadays, the common chemotherapeutica have a lot of side effects, therefore, drugs with fewer negative impacts are intensively searched for. The first part of the thesis focuses on the study of cis-[Pt(NH3)2Cl2] (cisplatin, DDP) and four platinum potential anticancer agents PtCl2(diaminocyclohexane), PtCl2(NH3)(cyclohexylamine) (JM118), cis-[PtCl2(NH3)(piperidine)] and trans-[PtCl2(NH3)(thiazole)]. Thermodynamic and kinetic parameters of reac- tions of these complexes in semi-hydrated and fully-hydrated form with guanine were studied using QM methods. The reaction with guanine is the key process ini- tiating the anticancer activity. Analyses of electron density were performed at the B3LYP/6-311++G(2df,2pd) level of theory in IEF-PCM model. The second part of the thesis studies the reaction of the so-called 'piano stool' Ru(II) transition metal complex, [Ru(II)(η6 -p-cymene(nalidixic acid)(H2O)]2+ , first with guanine using QM methods and second with ds-DNA model using QM/MM methods. The reaction site, which is described by QM method, is two consecutive guanines and the Ru(II) complex. Analyses of thermodynamic and kinetic parameters, and electron density were performed at the B97D/6-31G* level of theory. All the...

Content of this thesis is design of one-housing condensing steam turbine with two uncontrolled extractions. First part is describing design of balance scheme. Including cycle joints calculation, design of equipment for whole steam and condense cycle. Thesis continues with preliminary and detail design of regulativ stage. Main goal of this part is thermodynamic calculation of flow channel. Second part is describing lubricating oil and cooling system. Contains process description of lubricating oil scheme including calculation, specification of components and pipe branches design. Diploma thesis is finished with detail lubricating oil scheme.

This thesis deals with thermodynamic stability of thaumasite in dependence on selected external parameters. It focuses on optimizing preparation by ternesite hydration and comparing it with other methods in a suitable environment. Specifically, using the saccharate method, followed by the hydration of ternesite clinkers and the influence of calcium aluminate phases on the stability of thaumasite produced by the hydration of ternesite clinker. Subsequently, the phase composition was evaluated by X-ray diffraction analysis, in some cases by electron microscopy.