Charles University, Faculty of Pharmacy in Hradec Králové Department Department of Organic and Bioorganic Chemistry Candidate Mgr. Petr Matouš Supervisor prof. RNDr. Milan Pour, Ph.D. Titel of Doctoral Thesis Gold-Catalyzed Cyclizations of 1,5-Enynes This Ph.D. thesis deals with the development of gold(I)-catalyzed cyclizations of propargylamino acrylates (3-aza-1,5-enynes) in the presence of an external nucleophile. A library of tetrahydropyridines with an unusual hemiaminal ether functional group was thus prepared via the cyclization of a series of substituted enynes. The influence of the protective group as well as the substitution on the chemoselectivity of the reaction was demonstrated. The tetrahydropyridines were further utilized as precursors for the preparation of pharmaceutically important nitrogen heterocycles. The reduction of selected compounds furnished substituted piperidines, while Diels-Alder cycloaddition of alkenylated tetrahydropyridines gave rise to isoquinoline derivatives. Additional ortho-fused heterocycles (furopyridine, pyrrolopyridine and chromenopyridine) were prepared by the intramolecular version of the cyclizations of enynes with pending internal nucleophiles.

The thesis responds to the changes in customs procedures which Czech companies had to face after the Czech republic was joined to the customs territory of the EU. The first part of the thesis provides the basic characteristic of individual customs procedures and it is focused on the area of customs operations. The following sections concentrate on the issue of "transit" customs procedure. The scope of the thesis is a general approach of the realisation of international transport in transit. It demonstrates the most important changes which were caused by the membership of the Czech Republic in the EU. The thesis emhasizes Community transit, Common transit betweeen the Community and the EFTA countries and the carriage of goods based on the customs documents TIR a ATA. Due to its importance for facilitating international trade a special attention is given to the TIR customs transit system.

Title: Transition programmes as an assistance for physically handicaped person in transit from school to jobs Abstract: This diploma work engage problems of transition programme for people with physical handicape. It defines area of physical handicape, shows evolution of care for people with physical handicape and shows today's situation of comprehensive educational care and advisory system for person with physical handicape. It shows possibilities of social and labor integration with attentions to specific risks in life of person with physical handicape, especially unemployment. Fundamental part of this work describes transition programme, its principles and intentions and introduces realization of concrete example. Intention of this work is to find fields of frustration and find out whether transition programmes are focused on these fields to make their clients satisfied. That's why the exploration with the questionnaire was done. Its results show that the unemployment makes answerers unsatisfied the most. Because transition programmes are focused on searching for suitable jobs for their client, they should be support in it. But results show low education of answerers as well, but not dissatisfaction with this fact. To fortify chances to get suitable job clients should be more motivated to get higher...

This thesis deals with problems of transportation of goods from Turkey to the Czech Republic. The goal of this thesis is to provide a comprehensive overview of geo-political, legal and economic knowledge, which could serve as a guide for small transportation companies. The overview is divided into three parts. The first part deals with multilateral agreements governing international road transport with emphasis on the CMR Convention. The second part is devoted to customs issues, in particular transit procedure. The third part deals with transport from the economic point of view. In this part, two transportation routes are proposed, which are then analysed considering time, safety and cost.

Metal ions are a tempting tool for organisms thanks to the diversity of func- tions they have to offer, if they can be distinguished properly. Examining metal-ion selectivity computationally is challenging mainly due to complex- ity of electronic structure and solvation effects. A DFT-based protocol for predicting metal-ion selectivity of metal-binding systems was developed. The most essential part of the thesis is discussion of the magnitudes and sources of inherent errors, both for metal-ion complexes and small peptides. The thesis connects the work of four original papers. It includes computational and ex- perimental benchmarks, a case-study validating the computational protocol for obtaining energetic and structural insights, and attempts applying the protocol to peptidic systems. ii

PEDAGOGICKÁ FAKULTA UNIVERZITY KARLOVY Abstrakt k diplomové práci v anglickém jazyce Vzdělávání a příprava k povolání u lidí s mentálním postižením na Teplicku 30.6.2011 Autor : Zdeněk HERMAN Studijní program: Speciální pedagogika - obor vedoucí práce: doc. PhDr. Jan Šiška PhD. Abstrakt Despite all the problems in the Ranks of the cultural environment and the composition of the people after the unemployment I was led to believe it is not always the main factor in recruitment. Or maybe education is not the main determinant, though primarily affiliated, but the nature of personality, diligence and hard work are determinants, which are the quintessence of the employer's requirements. Sometimes such values in the family of people with mental disabilities are more problematic to implement, then the values would lead the school. The success of the equipment of the positive values depends on the quality of the school and its leadership. I knew that in Teplice there are that at least two schools are for high quality and fully prepare people with mental disabilities in practical life. However care for people with mental disability is complete, isn`t complete fully. There is not Transit program here, which is cooperation with Supported employment functioning in region. the largest work can be motivation of pupils...

The author focused her thesis on the transition from school to work in people with mental disabilities. The Current Status section provides the basic terminology definition of mental disability. The Quantitative Evaluation section captures the division and characteristics of individual degrees of mental disability. These are followed by a description of individual signs and causes of mental disability. To achieve a theoretical balance of the thesis, abilities of people with mental disabilities are assessed also in terms of a qualitative personality structure. The thesis describes specific characteristics of mental functions: perception, memory, thinking, attention, emotivity, and volitive traits. The thesis mentions documents affecting the rights of people with mental disabilities and it emphasises the right to education and employment. Opportunities for upbringing and education of persons with mental disabilities are monitored by their age and within the Czech educational system. Job opportunities for young people with mental disabilities are governed by the Employment Act and specific social programs also have their impacts; they are, for example, supported employment and transition programme, which provide support to people with mental disabilities in fulfilling their right to employment and integration into the mainstream society. The objective of the thesis is to describe the method of the transition programme and the definition of the supporting factors affecting the degree of inclusion in the occupational environment. To answer the set research questions, the author chose a qualitative research. The qualitative research is conducted through a case study. The author chose the following methods of data collection: participant observation, document analysis, and problem-focused interview, using instructions, with the parents of young mentally disabled people who have used or still use the transition programme service. The course of the programme and the fulfilment of the set objectives are influenced by the user?s personality, his or her natural social environment, schools and teachers, employers and workplace environment, and the consultant?s personality and the quality of their work with the user. The author perceives the transition programme as a specific programme, defined by legislation, of social rehabilitation service, which has its established place in an open civil society.

The Diploma thesis is focused on Community customs union and relations with third countries, regarding particularly customs procedure during foreign transit operations. It is aimed to summarize basic knowledge regarding TIR system operation with emphasis on its current development and modernization. At present, TIR regime is experiencing a very dynamic progress, and it is related both to its computerization and changes in the European Union, which tends to enhance safety standards on the international level when shipping the goods. Therefore, the means of communication are improved by the interconnection of main actors engaged in business transactions, such as national customs authorities and associations, traders and international organisations. The first part of the thesis deals with customs union and common trade policy of European Union. It defines the term of customs union and European customs union territory, specifies both internal and external aspects of customs union existence, and shortly describes the process of European customs union creation. The two following chapters are concerned with the customs administration, legislation and basic documentation forming customs legislation of European Union. The fourth chapter describes the development and customs union improvement with its new strategy and modernized customs union codex. The second part concentrates on the analysis of customs procedure in general and international customs regimes. It describes the basic terms used in customs administration, specifies the ways of customs debt calculation and factors which may lead to the customs debt. The closing chapter is devoted to transit regimes functioning not only on the territory of the European Union, but in third countries as well. The third part addresses the TIR transit regime. At the beginning, the foundation and historical development of the regime is described, followed by its mission, principles and territorial scope. In the next chapter the basic conditions of membership are identified. The following chapter is reserved for description and explanation of international guarantee system, mutual relations of its participants and forms of guarantee provision. In the last chapter the carnet TIR - main document used for customs purposes when shipping - is highlighted. The last chapter is focused on TIR system computerization, its innovation and improvement, and development mainly in recent years. The forth part of the thesis emphasizes membership advantages, particularly benefits of TIR system, and outlines the fields of the European Union and TIR system cooperation. The conclusion then summarizes important parts and key elements of the paper. When putting together the thesis, the latest available data on the TIR system progress regarding cooperation with the European Union were used, as the main aim of the thesis was to provide detailed information on the current situation and modernization of TIR regime.

The subject of the diploma thesis is the evaluation of transport movements in the territory of Boskovice. The main task of my diploma thesis is to analyze the existing state of parking in the town of Boskovice and to propose improvements in static traffic. Another task is to measure traffic engineering data. Six locations were selected for data exploration and evaluation. An important part of the diploma thesis is also a directional survey of transport for evaluation of transit and source transport.

This diploma thesis deals with the history and the development of the gas industry in Czechoslovakia, namely the construction of the transit gas pipeline and development of the gas transit system. One of the part of this thesis is a history of the coal gas and the reasons for its gradual replacement by a natural gas. The metodology of this thesis is based mainly on interviews based on the method of oral history, on archival records, and contemporary literature. Primarily it is focused on oral history fieldwork, particularly on the personal experiences of narrators who were direct participants in the construction. This work is also focused on the circumstances of the negotiations of the construction of a transit gas pipeline and further expansion of the transit system from the seventies to the nineties of the 20th century. Keywords Transit pipeline, natural gas, gas industry, economy, energetics, coal gas, normalization