No description available.

Work on developing an instrumental system for total analysis of triglycerides and phospholipids is presented. Initial chromatographic analysis using reversed-phase high performance liquid chromatography on C(,6)-bonded, 5 (mu)m silica stationary phase and acetonitrile-water (and dilute phosphoric acid with phospholipids) mobile phase is demonstrated. The Kovats index is shown to allow correlation of structure to retention behavior. An ultraviolet absorbance detector ((lamda)(,195m,)) and novel post-column reaction detector (p.c.r.) based on saponification, periodate oxidation and derivatization using a new class of reagents are used for detection. The p.c.r. is shown to be sensitive to samples in the lower nanomole-per-injection range. / A novel transport-thermal ionic detector for organophosphorus compounds and a new class of aldehyde reagents are introduced. The detector is capable of detecting some pesticides in the lower nanogram-per-injection range. The aldehyde reagents, called the Fluorals, of which Fluoral-P (4-amino-3-penten-2-one) is studied extensively, have promise of being useful for selective, rapid and sensitive (sub-nanomoles formaldehyde) determinations.

Background: Abnormalities in postprandial lipid metabolism may explain, in part, the 2 to 4 fold increased risk of coronary heart disease (CHD) in diabetic individuals compared with the general population. Aims: To develop an Oral Triglyceride Tolerance Test (OTTT) to evaluate reliably post challenge metabolism and to determine whether more physiologic insulin profiles can improve lipid responses in diabetic subjects. Methods: Post 50g fat and 50g carbohydrate challenge triglyceride and glucose profiles were measured 2 hourly for 8 hours on 2 occasions to establish test reproducibility and to characterise responses in type 2 diabetic and non diabetic subjects. The potential effects on post challenge lipid and glucose metabolism of modifying endogenous insulin delivery via the portal system or augmenting post challenge systemic insulin levels were assessed using the OTTT. Results: Reproducible post challenge triglyceride, NEFA, glycerol, glucose, insulin and C peptide responses were obtained in non diabetic and type 2 diabetic subjects. In type 2 diabetic subjects both ultra rapid endogenous and exogenous insulin delivery decreased post challenge hyperglycaemia and improved NEFA-glycerol suppression, relative to placebo and soluble insulin respectively. Enhancing portal insulin secretion had no effect on triglyceride levels. Increasing peripheral insulin levels showed no difference in triglyceride profiles between insulins tested although 6 hour triglyceride excursions were less than endogenous enhancement. Type 1 diabetic subjects displayed triglyceride profiles similar to non diabetic subjects, and reduced triglyceride excursion was seen with soluble than analogue insulin replacement. Conclusion: Increasing the peripheral to portal insulin ratio may relieve hepatic exposure to chronic hyperinsulinaemia characteristic of type 2 diabetes thus reducing post challenge triglyceride excursions. Improving postprandial metabolism, by delaying atherogenesis, may help decrease the risk of CHD.

Thesis (M.S.)--Ohio State University, 2008. / Title from first page of PDF file. Includes bibliographical references (p. 72-86).

Thesis (Ph.D.)--Drexel University, 2008. / Includes abstract and vita. Includes bibliographical references (leaves 155-172).

Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1993. / Vita. Abstract. Includes bibliographical references (leaves 109-123). Also available via the Internet.

Thesis (M.Res.(Med.)--University of Hong Kong, 2003. / Includes bibliographical references (leaves 54-61) Also available in print.

Thesis (M.S.)--Eastern Illinois University, 1987. / Includes bibliographical references (leaves 36-37).

No description available.

Thesis (M.S.)--California Polytechnic State University, 2009. / Title from PDF title page; viewed on January 12, 2010. Major professor: Tryg Lundquist, Ph.D. "Presented to the faculty of California Polytechnic State University, San Luis Obispo." "In partial fulfillment of the requirements for the degree [of] Master of Science in Civil and Environmental Engineering." "October, 2009." Includes bibliographical references (p. 92-100).