This work is focused on the techniques for overcoming the problem of scale in the evolutionary design of the combinational multipliers. The approaches to the evolutionary design that work directly with the target solutions are not suitable for the design of the large-scale structures. An approach based on the biological principles of development has often been utilized as a non-trivial genotypephenotype mapping in the evolutionary algorithms that allows us to design scalable structures. The instruction-based developmental approach has been applied to the evolutionary design of generic circuit structures. In this work, three methods are presented for the construction of the combinational multipliers which use a ripple-carry adder for obtaining the final product.