The concept of resource nexus is an acknowledgement of the interconnections between the uses of natural resources. This research will further the work done on the resource nexus by examining the multiple effects of measures taken in the Indian textile industry to lower the costs incurred due to the implementation of Zero Liquid Discharge (ZLD). ZLD combines a variety of technologies to cease the discharge of untreated water from production processes to the surrounding area. The paper will, based on surveys answered by an IKEA supplier and four of IKEA’s sub-suppliers of textile in India, present a multiple case study of possible multiple effects of projects undertaken to lower the increased cost of manufacturing with ZLD. Building on the multiple case study, and marrying it with the knowledge of the multiple benefits of energy efficiency improvements, the Value Added Water (VAW) tool, and the rebound effect, this paper constructs and offers a Multiple Effects Framework (MEF) for measures taken in factories as a response to the increased cost of manufacturing with ZLD. The framework handles both quantifiable and non-quantifiable multiple effects of measures taken, such as changes in resource use (water, energy, chemicals, materials), productivity and work environment. The MEF aggregates a more comprehensive picture of the overall effects of measures taken to adapt to the increased costs associated with ZLD in the textile supply chain, and can to a certain extent be applied to other factories facing a future mandate for ZLD. When changed accordingly, the framework can also be applied to other situations and industries as a decision-making and evaluation tool. In order to deepen the understanding of customer expectations and future trends, interviews were made with IKEA co-workers and a consultant involved with the factories investigated. Lessons learnt by IKEA and the consultant regarding ZLD implementation and the resource nexus are presented for internalization by factories, customers and authorities.