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Characterization of novel structure-regulatory relationships within interacting two-finger Cys₂His₂ zinc finger protein motifsWang, Zhonghua, Laity, John H., January 2008 (has links)
Thesis (Ph. D.)--School of Biological Sciences. University of Missouri--Kansas City, 2008. / "A dissertation in cell biology and biophysics and molecular biology and biochemistry." Advisor: John H. Laity. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed Sept.12, 2008. Includes bibliographical references (leaves 148-166). Online version of the print edition.
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Functional studies of BCL11A: a transcriptional repressor implicated in chromosome 2p13-disrupted malignancyLiu, Hui 28 August 2008 (has links)
Not available / text
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Functional studies of BCL11A a transcriptional repressor implicated in chromosome 2p13-disrupted malignancy /Liu, Hui. January 2002 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2002. / Vita. Includes bibliographical references. Available also from UMI Company.
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Analysis of ZNF6 : a human zinc finger gene related to the ZFY gene familyLloyd, Sarah Elisabeth January 1993 (has links)
No description available.
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Studies on HIV-1 virion infectivity factor / Feng Feng.Feng, Feng January 2004 (has links)
"October, 2004" / Bibliography: leaves 118-154. / xii, 154 leaves : ill. (some col.), plates (col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Sciences, Discipline of Microbiology and Immunology, 2005
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Structural characterization of N-terminus of XIAP associated factor 1Wong, Wai-fung., 黃偉鋒. January 2011 (has links)
The main focus of this thesis is to study the physical characteristics of the N-terminus of human XAF1 protein, a 17kD protein named NTA1, by biophysical methods. Structural studies of the N-terminus of XAF1 serves as a base for the studies of the structure and function relationship of the N-terminus, and the same maybe true for the full length XAF1.
Bioinformatics analysis shows that NTA1 shares high sequence identity with the TRAF-type zinc finger domain-containing protein 1 (TRAFD1) and FLN29. Protein structure prediction has been performed on NTA1 by the I-TASSER web server. The prediction result suggests that NTA1 is a structure that consists of α-helices which are joined by flexible linkers. The loose structure shown by I-TASSER is expected to have high solvent accessibility. This coincides with the deuterium exchange data. In addition, by the CD approach, NTA1 was estimated to contain high α-helix content. This result is consistent with the bioinformatics prediction and the secondary structure obtained from the chemical shift index method as well. The physical characterizations of NTA1 showed that NTA1 is a loosely packed protein; and the five zinc ions are bound in the protein structure. Based on the chemical shifts of β-carbons, the Cysteine residues Cys8, Cys11, Cys34, Cys37, Cys50, Cys59, Cys62, Cys86, Cys89 and Cys115 showed a significantly downfield shift, they are probably involved in the zinc ions coordination. The dynamic property of NTA1 was investigated by NMR techniques. Backbone dynamics of NTA1 reveal that NTA1 does not have a typical spherical structure, it is anisotropic. Residues corresponding to the zinc finger regions in the predicted structure show large R2/R1 and S2 values, while regions shown to be flexible linkers in the 3D structure prediction show small R2/R1 and S2 values. Thus, the protein structure homology modeling data are supported by the backbone dynamics data. / published_or_final_version / Chemistry / Master / Master of Philosophy
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Structural insights into eukaryotic DNA damage response from NMR studies of unusual zinc finger complexesEustermann, Sebastian January 2011 (has links)
No description available.
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Study of covalent and non-covalent interactions in ternary systems involving : metal/DNA-RNA/protein, where metal = Pt(II), Pd(II) /Anzellotti, Atilio I. January 2007 (has links)
Thesis (Ph. D.)--Virginia Commonwealth University, 2007. / Prepared for: Dept. of Chemistry. Includes bibliographical references. Also available online via the Internet.
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Characterization of the mechanism and function of C₂H₂ zinc finger protein CTIP2 in the developmental processes /Golonzhka, Olga. January 1900 (has links)
Thesis (Ph. D.)--Oregon State University, 2009. / Printout. Includes bibliographical references (leaves 166-180). Also available on the World Wide Web.
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Study of mutations in the zinc finger motif of yeast ribosomal protein YL37a /Rivlin, Anatoly A. January 1999 (has links)
Thesis (Ph. D.)--University of Chicago, Department of Biochemistry and Molecular Biology, December 1999. / Includes bibliographical references. Also available on the Internet.
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