Neurotransmitters play important roles in the early development of the mammalian central nervous system. Specifically, glutamate has been shown to mediate striatal neurogenesis via the ionotropic NMDA receptor. Here, it was investigated whether glutamate could exert an action on striatal neurogenesis by a metabotropic receptor mechanism in the developing rat. In vivo and in vitro methods were used to identify a role for the metabotropic glutamate receptor 5 (mGluR5) in striatal neurogenesis. mGluR5 glutamate receptor activation promotes neuroblast proliferation both in vivo and in vitro. The results of these experiments suggest that glutamate acting via the mGluR5 receptor plays an important novel role in striatal neurogenesis.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.97955 |
| Date | January 2005 |
| Creators | Gandhi, Rina. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Neuroscience.) |
| Rights | © Rina Gandhi, 2005 |
| Relation | alephsysno: 002331604, proquestno: AAIMR24670, Theses scanned by UMI/ProQuest. |
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