碩士 / 國立成功大學 / 生物學系碩博士班 / 92 / Tinnitus is a common symptom. People with serious tinnitus may be in the bad humor, attention-deficit, affecting life or insomnia. But the mechanisms of tinnitus is still unclear. Experiments had proved that take over dose of salicylate would cause tinnitus. It may affect the stability of the cochlear systems and central nervous systems. Taurine plays an important role in the auditory perception in the infants. It also can reduce the hydrops in the cochlea to protect hearing. Therefore, Taurine was used to investigate the tinnitus induced by the auditory dysfunctions. Abutilon indicum(L.) Sweet had been pointed out in many herbs medical books that it could cure tinnitus. So in this experiments with detecting the tinnitus animal model and the cochlear microphonics ,taurine and the cruded extracts of the Abutilon indicum(L.) Sweet were used to study to tinnitus induced by salicylate. The extracts of the Abutilon indicum(L.) Sweet was infused into stomach of guinea-pig with a gastric fistula, while taurine was injected intraperitoneally. We found that the retention period(the duration standing on the yellow zone ) and drinked water in the first testing day was not significant difference between the controlled and experimental groups (P>0.05, ANOVA). However, the retention period and the drinked water in the second testing day was shown a significant difference (P<0.01, ANOVA). The retention period of salicylate group and controlled saline groups was 83.9±13.9 min and 42.3±12.4 min, and the volume of drinked water was 11.7±4.4 and 30.0±5.3 ml, respectively. They were shown a very significant difference (P<0.01, t-test), and suggested that salicylate make guinea pig feel tinnitus. The retention period of taurine group and herb group was 33.5±12.5 and 44.9±11.6 min, and the level of drinked water was 29.4±14.9 and 22.5±5.1 ml, respectively. These two groups compared with those of salicylate groups were shown a significant difference (P<0.05). These results proved that both treatments could ameliorate the tinnitus behavior induced by salicylate. From the detection of cochlear microphonics(CM), we detected the CM of saline group and salicylate group was 132.5±54.0 and 224.0±58.0μV, respectively. It was showed that saliylate increased the CM(P=0.0089<0.01, t-test). The CM of the taurine group and the herb group was 156.7±62.8 and 139.2±62.3μV, respectively. It was shown a significant difference with that of salicylate group. It also showed that administrating taurine and the extracs of the Abutilon indicum(L.) Sweet in advance could decrease CM(P<0.05, test). These results suggest that taurine and the extracts of the Abutilon indicum(L.) Sweet can reduce tinnitus induced by salicylate, and can sustain the physiological functions of the outer hair cells. Therefore, both taurine and the extracts of the Abutilon indicum(L.) Sweet can decrease the perception of tinnitus by sustaining the functions of outer hair cells.
| Identifer | oai:union.ndltd.org:TW/092NCKU5112002 |
| Date | January 2003 |
| Creators | Chih-Ping Chung, 莊治平 |
| Contributors | Jinn-Ding Lin, 林進丁 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | en_US |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 80 |
Page generated in 0.0017 seconds