Reading disabilities (RD) have a significant genetic basis and chromosomes 3p12-q13 and 15q15-21 have shown replicated linkage to RD or reading measures. This study evaluated two RD candidate genes within these regions: DYX1C1 on chromosome 15q21 and ROBO1 on chromosome 3p12. DYX1C1 was tested for association using a family-based analysis of two independent samples. No statistically significant association was observed between the 10 tested DYX1C1 single nucleotide polymorphisms (SNPs) and RD or any of the quantitative traits. A review and meta-analysis of the potentially functional SNPs at the -3G/A and 1249G/T positions did not find strong support for these alleles as risk alleles for RD. ROBO1 was also evaluated in this study using SNPs that previously showed association with memory and reading measures in a population-based sample. None of the SNPs showed significant association with RD or any of the quantitative traits after correction for multiple testing.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/33566 |
| Date | 27 November 2012 |
| Creators | Tran, Christopher |
| Contributors | Barr, Cathy |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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