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<p>The motion of synthetic capsules and living cells in microchannels has been the
subject of numerous studies in the last decade due to its significance in engineer-
ing and biomedical applications. Cell sorting and separation are common processes
that are used for various purposes such as separation of leukocytes from blood used
in DNA sequencing. Isolation of rare cells in blood is needed for early diagnosis of
lethal diseases such as cancer. Cell isolation and enrichment will also provide a better
platform to biologists to study and analyze various properties of living cells. Thus,
there is a high demand for developing techniques to precisely control trajectories of
the cells and manipulate them in a desired manner. Microfluidic devices provide a
platform to achieve aforementioned needs while overcoming challenges such as sample
contamination, cost and complexity of the procedures. In many of these applications,
the background fluid is non-Newtonian due to the presence of DNA and proteins, or
polymers are added to control the trajectory of the cells. In this work, we first provide
a fundamental study on the dynamics of a single deformable capsule in a viscoelastic
matrix under a simple shear flow. Furthermore, we investigate the motion of a single
cell and suspension of cells in microchannels. The effects of cell size, inertia, cell
volume fraction, cell deformability and fluid elasticity are explored. Our findings on
capsule motion in the viscoelastic medium suggest that the use of constant-viscosity
viscoelastic fluid pushes the cells toward the channel centerline which can be used in
microfluidic devices used for cell focusing such as cytometers. However, viscoelastic
fluid with shear-thinning characteristics and drives the flowing cells toward the channel wall. Particle motion in viscoelastic matrix equilibrium positions of the particle
in the microchannel for a wide range of inertial and elastic effects. These fundamental studies can provide insight on the role of rheological properties of the fluid that
can be tuned to control the motion of the cells and particles for efficient design of
microfluidic devices. </p>
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| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/11310569 |
| Date | 04 December 2019 |
| Creators | Amir Hossein Raffiee (8071673) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/Elasto-Inertial_migration_of_particles_and_capsules_in_viscoelastic_microchannels/11310569 |
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