Molecular events involved in successful embryo implantation take place in defined time and space but are not generally well understood. Here for the first time, we use MALDI Imaging Mass Spectrometry (IMS) technologies to elucidate the spatial patterning of lipids and proteins during embryo implantation and demonstrate its value in helping to understand fertility and the reproductive process. For example, our analysis clearly shows previously unknown molecular distributions of lipids over time in this system. Beyond this example, we think that the approach and the concepts illustrated in this work will be of value in various areas of biology and will be critical for understanding many biological processes.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-12022008-205835 |
| Date | 03 December 2008 |
| Creators | Burnum, Kristin Elizabeth |
| Contributors | Richard M. Caprioli, H. Alex Brown, Michael R. Waterman, Jennifer A. Pietenpol, Daniel C. Liebler |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu//available/etd-12022008-205835/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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