Physiological functions of a biomacromolecule seem to be closely related to its molecular conformations. The knowledge of any conformational changes due to changes in its environment may lead to a proper understanding of its functions. Hyaluronic acid, a biomacromolecule with unusually high molecular weight and some important biological functions is the subject of the present work. A temperature-dependent transition in hyaluronate solution of 120 mg/ml concentration was observed at physiological temperature. It is shown that this temperature-dependent behavior can be related to the orientational polarizability term in the Debye theory of polar molecules in liquids.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc330801 |
| Date | 05 1900 |
| Creators | Jani, Shirish K. |
| Contributors | Roberts, James Andrew, Sears, Raymond E., Deering, William D., Redding, Rogers W., Mackey, H. J. |
| Publisher | North Texas State University |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | v, 80 leaves : ill., Text |
| Rights | Public, Jani, Shirish K., Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved. |
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