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Developing a macrocyclic sensor to probe interactions in biology

This thesis describes the development of a small molecule sensor for the detection of specific protein-protein interactions. The responsive sensor has been designed to produce a measurable signal upon a bivalent interaction with a dimeric protein target, and has the potential to probe the biological significance of specific binding events.

Identiferoai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:505063
Date January 2009
CreatorsWhite, Rebecca
PublisherUniversity of Leeds
Source SetsEthos UK
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation

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