In nature, all organisms face the daily challenges created by a fluctuating environment. Circadian clocks synchronize behaviour and physiology allowing an organism to adapt to and predict daily changes to environmental conditions. In the fruit fly, Drosophila melanogaster, circadian clocks reside in a set of ~150 neurons in the brain, collectively referred to as the central clock, and in the cells of many peripheral tissues. The central clock regulates daily behavioural rhythms, whereas peripheral clocks are thought to regulate the local metabolic activities of the cells in which they reside. In this thesis, I demonstrate that a peripheral clock resides in the abdominal fat body, a tissue analogous to the mammalian liver and adipocytes. Moreover, I show that flies display a temporal feeding pattern that is partly regulated by a peripheral clock. I propose that the central clock and peripheral clocks coordinate to regulate the timing of fly feeding behaviour.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/25800 |
| Date | 11 January 2011 |
| Creators | Shekhar, Shreya |
| Contributors | Levine, Joel |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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