The aim of this work was to assess the suitability of vibrational spectroscopic
techniques (Raman, FT-IR and FT-NIR spectroscopy) as a means for the solid-state
structural analysis of pharmaceuticals. Budesonide, fluticasone propionate, salbutamol
hemisulfate, terbutaline hemisulfate, ipratropium bromide, polymorphic forms of
salmeterol xinafoate and two polymorphic forms of sulfathiazole were selected since
they are used in the management of certain respiratory disorders and from different
chemical and pharmacological entities along with some pharmaceutical excipients.
Conventional visual examination is not sufficient to identify and differentiate spectra
between different pharmaceuticals. To confirm the assignment of key molecular
vibrational band signatures, quantum chemical calculations of the vibrational spectra
were employed for better understanding of the first five selected drugs. The nondestructive
nature of the vibrational spectroscopic techniques and the success of
quantum chemical calculations demonstrated in this work have indeed offered a new
dimension for the rapid identification and characterisation of pharmaceuticals and
essentially warrant further research.
The application of simultaneous in situ Raman spectroscopy and differential
scanning calorimetry for the preliminary investigation of the polymorphic
transformation of salmeterol xinafoate polymorphs and two polymorphic forms of
sulfathiazole has also been explored in this work leading to the development of a new
method for the solid-state estimation of the transition temperature of
entantiotropically related pharmaceutical polymorphs which represents the first
analytical record of the use of this approach for pharmaceutical polymorphs.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/3343 |
| Date | January 2009 |
| Creators | Ali, H.R.H. |
| Contributors | Edwards, Howell G.M. |
| Publisher | University of Bradford, School of Pharmacy |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Thesis, doctoral, PhD |
| Rights | <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>. |
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