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Previous issue date: 2008-02-20 / Funda??o Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro / An outbreak of salinomycin poisoning in rabbits is described. From a total of 2000 rabbits, at
least 27 died after coccidiostatic sulfaquinoxalin was substituted by salinomycin treatment. In
the ration fed to the rabbits 26.9 ppm of salinomycin were detected. Clinical signs included
anorexia, apathy and slowness with evolution to incoordination and recumbency. Gross
lesions consisted of pale areas in the skeletal muscles. Histopathological findings were severe
degenerative-necrotic myopathy associated with infiltration of neutrophils and macrophages.
One rabbit presented similar myocardial changes. Mineralization was seen in affected skeletal
muscles of some cases. Twenty rabbits were divided into five groups that received doses of
10, 25, 50, 75 and 100 ppm of salinomycin for reproduction of the suspected poisoning. The
administration of doses from 50 ppm on resulted in clinical signs seen in the spontaneous
outbreak. It was concluded that an error of the dosage for treatment was the cause of the
rabbit deaths described. / Relata-se, pela primeira vez, um surto de intoxica??o por salinomicina em coelhos. De 2000
animais, no m?nimo 27 morreram ap?s troca do coccidiost?tico sulfaquinoxalina pela
salinomicina. A an?lise de parte da ra??o detectou 26,9 ppm de salinomicina. Os sinais
cl?nicos observados foram anorexia, apatia e lentid?o com evolu??o para incoordena??o dos
movimentos e dec?bito. As les?es macrosc?picas consistiram de ?reas p?lidas na musculatura
esquel?tica. O exame histopatol?gico evidenciou miopatia degenerativo-necr?tica
coagulativa. Adicionalmente, verificou-se rea??o inflamat?ria constitu?da por neutr?filos e
macr?fagos. Um coelho apresentou les?es similares no mioc?rdio. Em alguns casos,
mineraliza??o estava presente nos m?sculos esquel?ticos afetados. Vinte coelhos
experimentais foram divididos em 5 grupos que receberam 10, 25, 50, 75 e 100 ppm de
salinomicina por via oral, com a finalidade de reproduzir a intoxica??o. Os animais que
receberam a partir de 50 ppm de salinomicina apresentaram sinais cl?nicos semelhantes aos
observados no surto espont?neo. Nossos resultados indicam que, provavelmente, erro na
mistura da subst?ncia ? ra??o causou a morte dos coelhos.
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:tede/760 |
| Date | 20 February 2008 |
| Creators | Nogueira, Vivian de Assun??o |
| Contributors | Peixoto, Paulo Fernando de Vargas, Fran?a, Ticiana do Nascimento |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Curso de P?s-Gradua??o em Ci?ncias Veterin?rias, UFRRJ, Brasil, Parasitologia Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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