Includes abstract. / Includes bibliographical references. / In this project, we review some existing pathway-based approaches for GWA study analyses, by exploring different implemented methods for combining effects of multiple modest genetic variants at gene and pathway levels. We then propose a graph-based method, ancGWAS, that incorporates the signal from GWA study, and the locus-specific ancestry into the human protein-protein interaction (PPI) network to identify significant sub-networks or pathways associated with the trait of interest. This network-based method applies centrality measures within linkage disequilibrium (LD) on the network to search for pathways and applies a scoring summary statistic on the resulting pathways to identify the most enriched pathways associated with complex diseases.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uct/oai:localhost:11427/5968 |
| Date | January 2014 |
| Creators | Mbiyavanga, Mamana |
| Contributors | Mulder, Nicola |
| Publisher | University of Cape Town, Faculty of Science, Department of Molecular and Cell Biology |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Master Thesis, Masters, MSc |
| Format | application/pdf |
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