Ion mobility-mass spectrometry (IM-MS) is an analytical technique used to separate gas-phase ions based on their structural properties such as size and shape as well as their mass, in the IM and MS dimensions, respectively. Furthermore, this analytical technique has become a widely used tool for a wide variety of fields. Its great sensitivity and selectivity provides scientists numerous advantages for the analysis of complex samples of numerous analyte types (biomolecules, synthetic polymers, metals, etc.) spanning a broad dynamic range. It is well known, that MS can be greatly improved when a separation is performed prior to ionization, more commonly liquid chromatography (LC). However, in the pursuit of faster separations and increased analyte coverage, both gas- and condensed phase techniques such as ion mobility (IM), supercritical fluid chromatography (SFC) and size exclusion chromatography (SEC) have been implemented. Their orthogonality was explored in the metabolome characterization of a wide variety of biological and synthetic samples.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-04202016-114145 |
| Date | 21 April 2016 |
| Creators | Montenegro Burke, Jose Rafael |
| Contributors | Janet E. Macdonald, John A. McLean, David E. Cliffel, David M. Hercules, Ned A. Porter |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-04202016-114145/ |
| Rights | restrictsix, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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