This dissertation focuses on the development of synthetic methodologies in organic synthesis in two different areas. Chapter 1 discusses the more recent examples of transforming alcohols to their corresponding alkyl chlorides. The first area of our groups research interest is the development of a mild chlorination method from unactivated alcohols, detailed in Chapter 2.
Chapter 3 provides an insight into the history of oxyallyl cations, the basis of the second methodology development project in our laboratory. This chapter focuses on the traditional reactions that utilize these reactive intermediates, and it also showcases the concept of direct nucleophilic addition and the applications of the รก-indole ketones. Chapters 4 through 7 detail the discovery and development of a novel method involving the use of protected oxyallyl cation intermediates. In these chapters, the reactivity of starting materials, nucleophilic additives, solvents, and catalysts are described in regards to the formation of a variety of distinctive small molecules.
| Identifer | oai:union.ndltd.org:LSU/oai:etd.lsu.edu:etd-02262016-201516 |
| Date | 13 April 2016 |
| Creators | Ayala, Caitlan Elizabeth |
| Contributors | Ragains, Justin, Vicente, Graca, Stanley, George, Allen, Austin |
| Publisher | LSU |
| Source Sets | Louisiana State University |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lsu.edu/docs/available/etd-02262016-201516/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached herein a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to LSU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below and in appropriate University policies, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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