Stroke is a common illness with significant morbidity and mortality. Thrombolysis is the only approved therapy for ischemic stroke. Current protocols utilize a three hour time window from symptom onset for treatment eligibility. Public education campaigns regarding the symptoms of stroke have been advocated as a means to increase the treatment rates. A Markov model was constructed to simulate the experience of a population at risk for stroke. The probabilities of clinical events and health state utilities were extracted from the literature or estimated. Systematic reviews of community interventions in stroke and chest pain were performed. Base case analysis suggests that community intervention is the preferred strategy. The preference was robust in the face of multiple sensitivity analyses. A small incremental gain of 56 minutes was noted in life expectancy with a gain of 69 minutes in quality-adjusted life expectancy and 56 minutes in discounted quality-adjusted life expectancy.
| Identifer | oai:union.ndltd.org:uottawa.ca/oai:ruor.uottawa.ca:10393/27296 |
| Date | January 2006 |
| Creators | Sharma, M |
| Publisher | University of Ottawa (Canada) |
| Source Sets | Université d’Ottawa |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | 225 p. |
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