Does Baseline HDL-C Influence the Dose and Response Relationship Between Acute Exercise and Post-exercise HDL-C Improvement? Purpose: The purpose of this study was to determine if high density lipoprotein cholesterol (HDL-C) status (low vs. normal) affects the magnitude of post-exercise HDL-C changes over a 24 hour period and whether different caloric expenditures (300, 500 and 700 kcals) augment this relationship. Methods: Two groups of healthy untrained male volunteers participated in this study. Subjects were assigned to one of two groups based upon their resting HDL-C level. The LOW HDL-C group consisted of 13 subjects with clinically low HDL-C (< 40mg/dl) and the NORMAL HDL-C group consisted of 14 subjects with normal HDL-C (≥ 45mg/dl). Age, diet, VO2max and anthropometric data were collected prior to initiation of the experimental protocol and were similar for both groups. The characteristics of the LOW group were 21.9 ± 2.0 yrs of age, 1.8 ± 0.1 m tall, weighed 80.9 ± 7.9 kg, and had a BMI of 25.2 ± 2.2 kg/m2, a VO2max of 45.8 ± 5.1 ml/kg/min and a resting HDL-C of 35.7 ± 2.7 mg/dl. Characteristics of the NORMAL group were 23.4 ± 7.1yrs of age, 1.8 ± 0.1 m tall, weighed 78.6 ± 7.6 kg, and had a BMI of 24.3 ± 2.5 kg/m2, a VO2max of 47.5 ± 4.8 ml/kg/min and a resting HDL-C of 53.9 ± 5.8 mg/dl. Subjects randomly completed three nonconsecutive exercise trials (300, 500, and 700 kcals) on a treadmill at 65% of VO2max. Blood samples were collected pre-exercise (PRE), immediately post-exercise (IP), and 24 hours post-exercise (+24). Each sample was analyzed for HDL-C and its subfractions (HDL2-C and HDL3-C) and was corrected for plasma volume shifts. Results: There was no significant main effect of group or condition (kcal expenditure) and no interactions among variables. HDL3-C increased significantly IP regardless of group or caloric expenditure, but was not different from PRE at +24. HDL-C increased (5.6%) significantly IP regardless of group when the 500 and 700 kcal trials were combined, again the effect was transient. Individually, no caloric expenditure produced HDL-C or subfraction changes that were significantly different from one another. Conclusions: Baseline HDL-C status had no significant effect on the magnitude of post-exercise HDLC alterations. Furthermore, post-exercise improvements of HDL-C in untrained men occur via increases in HDL3-C and primarily at caloric expenditures above 300 kcal / A Thesis submitted to the Department of Nutrition, Food and Exercise Sciences in partial fulfillment of the requirements
for the degree of Master of Science. / Fall Semester, 2008. / October 7, 2008. / Blood Lipids, High Density Lipoprotein, Acute Exercise, Cholesterol / Includes bibliographical references. / Robert J. Moffatt, Professor Directing Thesis; Lynn B. Panton, Committee Member; Laurie M. Grubbs, Committee Member.
| Identifer | oai:union.ndltd.org:fsu.edu/oai:fsu.digital.flvc.org:fsu_254159 |
| Contributors | Lawrence, Tait (authoraut), Moffatt, Robert J. (professor directing thesis), Panton, Lynn B. (committee member), Grubbs, Laurie M. (committee member), Department of Nutrition, Food, and Exercise Science (degree granting department), Florida State University (degree granting institution) |
| Publisher | Florida State University, Florida State University |
| Source Sets | Florida State University |
| Language | English, English |
| Detected Language | English |
| Type | Text, text |
| Format | 1 online resource, computer, application/pdf |
| Rights | This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). The copyright in theses and dissertations completed at Florida State University is held by the students who author them. |
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