Blood-brain barrier disruption in Parkinsons disease and Parkinsons disease models that involve dopaminergic neurodegeneration has been minimally evaluated despite mounting evidence for its involvement. Oxidative stress and neuroinflammation are both involved in Parkinsons disease pathology and also both contribute to blood-brain barrier dysfunction, creating the likelihood that blood-brain barrier disruption is also a pathological feature of the disease. Disruption of the blood-brain barrier can lead to an increased susceptibility to neuronal injury and potentially neurodegeneration due to the invasion of peripheral factors such as immunoglobulins and environmental toxins into the brain. An understanding of mechanisms by which blood-brain barrier disruption occurs may lead to the development of new approaches for the treatment of neurologic diseases such as Parkinsons disease.
| Identifer | oai:union.ndltd.org:PITT/oai:PITTETD:etd-12022007-112205 |
| Date | 25 January 2008 |
| Creators | Larsen, Niccole Jewel |
| Contributors | Teresa G. Hastings, J. Patrick Card, J. Timothy Greenamyre, Donald B. DeFranco, Bryan K. Yamamoto, Ruth G. Perez |
| Publisher | University of Pittsburgh |
| Source Sets | University of Pittsburgh |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.pitt.edu/ETD/available/etd-12022007-112205/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to University of Pittsburgh or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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