Procaine was first synthesized by Einhorn in 1905. Xylocaine (Lidocaine) was synthesized by Löfgren in 1948. Wiedling, Löfgren and Tegner reported on Propitocaine (Citanest) in 1960. They have been used mainly for local and regional anesthesia in surgery and dentistry. The first review of the use of local anesthetics by the intravenous route was reported by Graubard and Peterson in 1950. Gilbert et al (1951) reported similar results using intravenous Xylocaine. In their cases they reported effective analgesia when the Xylocaine was used in cases of advanced cancer. They reported that the danger of side-effects appeared to be less than with Procaine.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.115346 |
| Date | January 1964 |
| Creators | Baiz, Theodore. C. |
| Contributors | Jasper, H. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Health Sciences.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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