Thesis: S.M., Massachusetts Institute of Technology, Department of Physics, 2017. / Cataloged from PDF version of thesis. / Includes bibliographical references (pages 63-68). / Populations are subject to mutations conferring beneficial effects, as well as mutations conferring deleterious effects. Even if deleterious mutations occur much more frequently than beneficial mutations, the contribution of deleterious mutations to the overall rate of change of the population-wide mean fitness may be limited, due to the efficient action of selection. However, in particularly rapidly evolving populations, the stochastic accumulation of deleterious mutations may negate a significant fraction of the fitness increments provided by beneficial mutations, or even result in an overall decrease in fitness over time. Here we obtain a constraint on beneficial and deleterious mutation rates and selection pressures in order for positive adaptation to counterbalance fitness decline via Muller's ratchet. The steady state that separates parameter regimes of positive adaptation and negative adaptation is characterized by appealing to the exponential dependence of fixation probabilities on fitness effect sizes. We consider a range of fitness-mediated epistatic interactions and the corresponding implications regarding the existence, location and stability of long-term evolutionary fixed points. / by Matthew Melissa. / S.M.
| Identifer | oai:union.ndltd.org:MIT/oai:dspace.mit.edu:1721.1/115020 |
| Date | January 2017 |
| Creators | Melissa, Matthew (Matthew J.) |
| Contributors | Mehran Kardar., Massachusetts Institute of Technology. Department of Physics., Massachusetts Institute of Technology. Department of Physics. |
| Publisher | Massachusetts Institute of Technology |
| Source Sets | M.I.T. Theses and Dissertation |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | 68 pages, application/pdf |
| Rights | MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission., http://dspace.mit.edu/handle/1721.1/7582 |
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