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Involvement of β-Arrestin-2 in Modulation of the Spinal Antinociception Induced by μ-Opioid Receptor Agonists in the Mouse

Beta-arrestins have been suggested to regulate μ-, δ-, and κ-opioid receptor-mediated responses. In the present study, we examined the effects of pretreatment with β-arrestin-2 antibody on tail-flick inhibition induced by opioid receptor agonists in the mouse spinal cord. Intrathecal (i.t.) pretreatment with β-arrestin-2 antibody potentiated the antinociception induced by i.t.-administered μ-opioid receptor agonists [D-Ala2,NMePhe4,Gly-ol5]enkephalin (DAMGO) and endomorphin-1, but not endomorphin-2, the δ-opioid receptor agonist [D-Ala2]deltorphin II or the κ-opioid receptor agonist U50,488H. The present result suggests that β-arrestin-2 may tonically down-regulate a selected population of μ-opioid receptors activated by endomorphin-1 or DAMGO in the mouse spinal cord.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-15260
Date31 July 2003
CreatorsOhsawa, Masahiro, Mizoguchi, Hirokazu, Narita, Minoru, Nagase, Hiroshi, Dun, Nae J., Tseng, Leon F.
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
SourceETSU Faculty Works

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