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Inhalation Toxicity of (1→3)-β-D-Glucan: Recent Advances

To investigate the effects of (1→3)-β-D-glucan after inhalation, animals were exposed to different forms of glucan and the number of lung lavage cells was determined 24 h after exposure. None of the different forms assayed caused any increase in cell numbers. In animals exposed to endotoxin, all types of cells were increased after 24 h. A simultaneous exposure to curdlan reduced this increase in a dose-related fashion. The results suggest that (1→3)-β-D-glucan-related acute injury to the lung is induced by mechanisms other than those induced by inflammagenic agents such as endotoxin.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-14848
Date01 December 1997
CreatorsFogelmark, Birgitts, Sjöstrand, Margarets, Williams, David, Rylander, Ragnar
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceETSU Faculty Works
Rightshttp://creativecommons.org/licenses/by/4.0/

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