Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

Description

Yes / The complexes [RuCp*(PP)Cl] (Cp* = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp#(PP)Cl] (Cp# =
C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp*(dppm)(CH3CN)][SbF6] [3] were synthesized
and evaluated in vitro as anticancer agents. Compounds 1–3 gave nanomolar IC50 values against
normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their
high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.

Links & Downloads

1. Rodríguez-Bárzano A, Lord RM, Basri AM, Phillips RM, Blacker AJ and McGowan PC (2015) Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands. Dalton Transactions. 44: 3265-3270.
2. http://hdl.handle.net/10454/9498
3. https://doi.org/10.1039/c4dt02748e

Tags

(η6-arene)-ruthenium

Anticancer agents

η5-C5(CH3)4R ruthenium complexes

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/9498
Date	05 January 2015
Creators	Rodríguez-Bárzano, A., Lord, Rianne M., Basri, A.M., Phillips, Roger M., Blacker, A.J., McGowan, P.C.
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, Accepted manuscript
Rights	© 2015 RSC. Reproduced with permission from the publisher in accordance with the publisher's self-archiving policy., Unspecified