Thesis (MMed in Psychiatry) -- University of Limpopo, 2010 / Background: Bipolar disorder is a lifelong illness typically presenting with frequent
relapses and/or recurrences. Bipolar disorder carries a high morbidity and mortality and
can cause significant functional impairment. In understanding the relapsing course of the
illness, chronicity may be reduced by preventing or delaying the occurrence of new
episodes.
Objectives: The objectives of this study were to establish the prevalence of new episodes
in patients with bipolar I disorder and to determine predictors of new episodes.
Methods: This was a retrospective, descriptive study based on the review of medical
records of patients with bipolar I disorder seen at Dr. George Mukhari Hospital –
psychiatry unit between the period of 1 June 2007 to 1 June 2008. Data concerning sociodemographic
parameters of the patients and psychiatric information was collected using a
data collection sheet.
Results: Data was extracted and analysed from a total of 143 patient records. Ninety
(63%) experienced new episodes and fifty-three patients (37%) did not have any new
episodes. Seventy-nine patients (55%) had one or more manic episodes (mean=0.64) and
nineteen (13.38 %) had one or more depressive episodes. (Mean=0.14). The maximum
number of new episodes was 2 and the mean was 0.78. The most recent episode was
manic in seventy-six patients (84%). The mean number of hospital admissions was 0.88.
Of the patients that had new episodes, the age ranged from 18 to more than 55 years, the
vast majority were black (94%) and of Christian faith (97%). More than half were female
(58%) and single (49%), with 1-2 children (48%). The majority achieved high school
education (60%), and were unemployed (70%). Only 47% were receiving a disability
grant. New episodes were more prevalent in patients who experienced a younger age of
onset of illness (41% in the 18-24 year age group) and who were ill for more than ten
years (43%). Less than half had a positive family history of mental illness (43%), 39%
had a history of substance use, the most common substance being alcohol (54%), and
39% suffered from one or more comorbid medical illnesses. 78% of the patients who had
new episodes were on antipsychotics, 93% were on mood stabilisers, and 69% were on a
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combination of mood stabilisers and antipsychotics. The only factor that was significantly
predictive of new episodes was poor compliance.
Conclusion: There is a high prevalence of relapse in patients with bipolar I disorder,
particularly to the manic pole. Compliance with medication remains a serious problem
and is associated with the occurrence of new episodes. Improved treatments should
include biopsychosocial strategies, identification of risk factors for relapse/recurrence and
early and consistent intervention.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:ul/oai:ulspace.ul.ac.za:10386/394 |
| Date | January 2010 |
| Creators | Ballyram, T |
| Contributors | Rataemane, S.T. |
| Publisher | University of Limpopo (Medunsa) |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | xii, 47 p. |
| Relation | Acrobat 6 |
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