Alzheimer’s Disease is a growing public health problem, with the number of Americans suffering from the disease projected to more than double from 5.8 million today to 13.8 million in 2050. While there is still no cure for Alzheimer’s Disease, a preventative strategy may mitigate its cost to society in the future. Previous studies have shown an ameliorative effect of perinatal choline supplementation on amyloidosis in the hippocampus of APP.PS1 mice. In this study, we test the effects of perinatal choline supplementation on the APP.NLGF strain of mice – which uses a gene knock-in strategy to avoid the non-physiologic overexpression of amyloid precursor protein and better recapitulate the disease in humans. When compared to APP.NLGF mice raised on a control diet, the perinatal choline supplemented APP.NLGF mice exhibited: i) an amelioration of learning and memory deficits in 9- and 12-months old mice as measured by contextual fear conditioning, ii) reduced amyloidosis in the cortex of 9- and 12-months old mice, and iii) an age- and brain region-dependent response to perinatal choline supplementation. These results suggest that increasing the dietary intake of choline during pregnancy may protect the offspring from AD-associated cognitive decline and amyloidosis.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/44003 |
| Date | 09 March 2022 |
| Creators | Chou, Jay |
| Contributors | Blusztajn, Jan K., Mellott, Tiffany J. |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
| Rights | Attribution 4.0 International, http://creativecommons.org/licenses/by/4.0/ |
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