Chu Lut-Hey. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references (leaves 137-140). / Abstracts in English and Chinese. / Abstract --- p.II / Acknowledgement --- p.V / List of Tables --- p.IX / List of Figures --- p.X / List of Abbreviations --- p.XIII / Chapter 1 --- Introduction / Chapter 1.1 --- Objectives.l --- p.1 / Chapter 1.2 --- What is diabetes mellitus?. --- p.1 / Chapter 1.3 --- "Review of ""Technique for blood glucose measurement""" --- p.3 / Chapter 1.3.1 --- Conventional blood glucose meter --- p.4 / Chapter 1.3.2 --- Semi-invasive blood glucose meter --- p.5 / Chapter 1.3.3 --- Surfacelasmon resonance (SPR) method --- p.6 / Chapter 1.3.4 --- Non-invasive blood glucose meters --- p.7 / Chapter 1.4 --- Research directions --- p.8 / Chapter 1.5 --- Data analysis methods --- p.9 / Chapter 1.6 --- Organization of the thesis --- p.10 / Chapter 2 --- Spectral Data Analysis Methods / Chapter 2.1 --- What is spectral data? --- p.12 / Chapter 2.2 --- Nature of spectral data --- p.12 / Chapter 2.3 --- How to interpret the spectral data? --- p.15 / Chapter 2.3.1 --- Linear regression --- p.15 / Chapter 2.3.2 --- Multiple linear regression (MLR) --- p.17 / Chapter 2.3.2.1 --- Data reduction --- p.19 / Chapter 2.3.3 --- Bilinear modeling (BLM) --- p.21 / Chapter 2.3.3.1 --- artial least square regression (PLSR) --- p.23 / Chapter 2.3.3.2 --- Model reliability --- p.24 / Chapter 2.3.3.3 --- LS segmentation analysis --- p.25 / Chapter 2.4 --- Session discussion and conclusion --- p.27 / Chapter 3 --- Surfacelasmon Resonance (SPR) Experiments and Analysis / Chapter 3.1 --- Intrcduction --- p.29 / Chapter 3.2 --- Theory --- p.30 / Chapter 3.2.1 --- Maxwell's equations --- p.30 / Chapter 3.2.2 --- olarization of EM wave --- p.32 / Chapter 3.2.3 --- Boundary condition --- p.33 / Chapter 3.2.4 --- Total internal reflection --- p.37 / Chapter 3.2.5 --- hase shift of total internal reflection wave --- p.38 / Chapter 3.2.6 --- Kretschmannrism configuration --- p.38 / Chapter 3.2.7 --- Conditions affecting SPR --- p.41 / Chapter 3.3 --- Different SPR configuration systems --- p.44 / Chapter 3.3.1 --- rinciple of angular-based interrogation SPR setup --- p.44 / Chapter 3.3.2 --- rinciple of intensity-based interrogation SPR setup --- p.45 / Chapter 3.3.3 --- rinciple of wavelength-based interrogation SPR setup --- p.45 / Chapter 3.3.4 --- hase-based interrogation SPR setup --- p.47 / Chapter 3.3.4.1 --- Michelson Interferometer --- p.48 / Chapter 3.3.4.2 --- Thehase-based setup --- p.49 / Chapter 3.3.5 --- Comparison and discussion of different configurations --- p.51 / Chapter 3.4 --- SPR experiment adopts wavelengths-based interrogation setup --- p.54 / Chapter 3.4.1 --- The experiment setup --- p.54 / Chapter 3.4.1.1 --- Samplereparation --- p.58 / Chapter 3.4.1.2 --- Experiment Result using 928 nm and 1120 nm initial resonant wavelength --- p.58 / Chapter 3.4.2 --- Experimental data analysis --- p.60 / Chapter 3.4.2.1 --- Conventional SPR data analysis --- p.61 / Chapter 3.4.2.1.1 --- Data analysis using minimum hunting witholynomial fit --- p.62 / Chapter 3.4.3 --- LS regression analysis for SPR data --- p.67 / Chapter 3.5 --- Session discussion and conclusion --- p.71 / Chapter 4 --- Near-Infrared Spectroscopy Experiment and Analysis / Chapter 4.1 --- Overview of near-infrared spectroscopy --- p.74 / Chapter 4.1.1 --- Electromagnetic spectrum --- p.75 / Chapter 4.1.2 --- Molecules vibration --- p.76 / Chapter 4.1.3 --- Law of absorption: Lambert-Beer Law --- p.77 / Chapter 4.2 --- Near Infrared Spectrometer --- p.79 / Chapter 4.2.1 --- Dispersive NIR spectrometer --- p.79 / Chapter 4.2.2 --- Fourier-Transformed NIR spectrometer --- p.83 / Chapter 4.2.3 --- Comparison between dispersive NIR and FT-NIR spectrometers --- p.85 / Chapter 4.2.4 --- Self-established monochromator based spectrometer --- p.87 / Chapter 4.2.4.1 --- Choose of detector andhotonic signal conversion unit --- p.90 / Chapter 4.3 --- Experimental result of NIR-spectrum by self-established spectrometer --- p.95 / Chapter 4.3.1 --- New approach for improving RMSEP without normalization of water spectrum as background information --- p.105 / Chapter 4.4 --- Experimental results of NIR-spectrum by commercial spectrometers --- p.109 / Chapter 4.5 --- Instrumentation limitation of NIR spectrometer --- p.117 / Chapter 4.6 --- Session Discussion and conclusion --- p.119 / Chapter 5 --- Conclusions and Suggestions for the Future Work / Chapter 5.1 --- Research aim and contributions --- p.126 / Chapter 5.2 --- Discussion on experiments --- p.128 / Chapter 5.3 --- Future work --- p.131 / Chapter 5.4 --- Conclusion --- p.134 / Reference: --- p.136 / Appendixes: --- p.141 / Appendix A Different approaches for non-invasive glucose measurement --- p.142 / Appendix B Calibration model of the SPR experimental result with 1120 nm as initial resonance wavelength --- p.145 / Appendix C Matlabrogram written for data analysis and simulation --- p.146 / Appendix D Detail specification of the monochromator using in our laboratory --- p.150 / Appendix E Monochromator Controlrogram --- p.156 / Appendix F The throughput example copied from the handbook of ORIEL Instruments --- p.165 / Appendix G RMSEPlot of the data obtained by self-established spectrometer with and without datare-treatments --- p.166 / "Appendix H RMSEPlot of the raw data obtained from the three different commercial machines (Vector-22N/C, NIRSystem 6500 and NIRSystem XDS) with and without datare-treatment" --- p.176
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_324985 |
| Date | January 2004 |
| Contributors | Chu, Lut-Hey., Chinese University of Hong Kong Graduate School. Division of Electronic Engineering. |
| Source Sets | The Chinese University of Hong Kong |
| Language | English, Chinese |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, xiii, 184 leaves : ill. ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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