The objectives were to explore cognitive function in older adults with Type 2 Diabetes Mellitus (T2DM) through two studies: 1) a pilot study involving the metabolic stress of glucose ingestion and the environmental stress of a functional magnetic resonance imaging (fMRI) environment and 2) an fMRI study exploring the neural mechanisms through hippocampal and prefrontal functional imaging during memory and executive functioning tasks. In T2DM subjects, environmental stress produced greater impairment in memory performance and metabolic stress produced overestimation of memory performance, with similar executive functioning, relative to healthy subjects (pilot study). T2DM subjects also sowed reduced hippocampal and greater prefrontal activation compared to healthy subjects (fMRI study). Moreover, the metabolic stress caused greater hippocampal and prefrontal activation in healthy subjects relative to placebo (fMRI study). These results indicate plausible neural mechanisms behind T2DM- and stress-associated cognitive impairments that can be used for future improvements in cognitive retention and rehabilitation.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/31401 |
| Date | 19 December 2011 |
| Creators | Rahman, Tupur |
| Contributors | Greenwood, Carol |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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